Ebook: Theories of Immune Networks

For a long time, immunology has been dominated by the idea of a simple linear cause-effect relationship between the exposure to an antigen and the production of specific antibodies against that antigen. Clonal selection was the name of the theory based on this idea and it has provided the main concepts to account for the known features of the immune response. More recently, immunologists have discovered a wealth of new facts, in the form of different regulatory cells (helpers, suppressors, antigen presenting cells), genetic determinations of immune responses such as those involved in graft re­ jections, different molecular structures responsible for intercellular interactions such as interleukins, cytokins, idiotype-antiidiotype recognition and others. While furthering our understanding of the local interactions (molecular and cellular) in­ volved in the immune response, these discoveries have led to a questioning of the simplicities of the classical clonal selection theory. It is clear today that every single immune response is a cooperative phenomenon involving several different molecular and cellular interactions taking place in a coupled manner. In addition, cross reactivity to different antigens has shown that responses of the whole im­ mune system to different antigens are not completely isolated from one another and that the history of encounters with different antigens plays a crucial role in the maturation of the whole system. Thus, problems of complexity, generation of di­ versity and self-organization have entered the field of immunology.

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The immune system may be viewed as a network of interacting cells producing cooperative behavior with the properties of memory and learning. Like the central nervous system, it can be studied as a parallel computing network, endowed with cognitive capabilities. The contributions in this book discuss the various formal approaches available today to analyze the behavior of immune networks. The first part of the book presents empirical data on some molecular and cellular interactions, mainly idiotypic-antiidiotypic, which constitute the substrate for the connections between different cell populations. Automata network behavior can be used to model not only idiotypic-antiidiotypic interactions but also other interactions between different classes of lymphocytes as well as receptor-antigen interactions. Thus the concept of immune networks receives a more precise meaning. Two different approaches are then discussed. Part two discusses the "large" network approach made of all possible idiotypic-antiidiotypic interactions with cross-reactivity. Part three discusses the small network approach, better fitted to represent and analyze specific data on limited interactions. The book presents the first applications of neural network computation to immunology.

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The immune system may be viewed as a network of interacting cells producing cooperative behavior with the properties of memory and learning. Like the central nervous system, it can be studied as a parallel computing network, endowed with cognitive capabilities. The contributions in this book discuss the various formal approaches available today to analyze the behavior of immune networks. The first part of the book presents empirical data on some molecular and cellular interactions, mainly idiotypic-antiidiotypic, which constitute the substrate for the connections between different cell populations. Automata network behavior can be used to model not only idiotypic-antiidiotypic interactions but also other interactions between different classes of lymphocytes as well as receptor-antigen interactions. Thus the concept of immune networks receives a more precise meaning. Two different approaches are then discussed. Part two discusses the "large" network approach made of all possible idiotypic-antiidiotypic interactions with cross-reactivity. Part three discusses the small network approach, better fitted to represent and analyze specific data on limited interactions. The book presents the first applications of neural network computation to immunology.
Content:
Front Matter....Pages I-VIII
Introduction to Immune Networks....Pages 1-3
Front Matter....Pages 5-5
Natural Id-Anti-Id Networks and the Immunological Homunculus....Pages 6-12
Self-Nonself Immunological Tolerance and Idiotype Networks....Pages 13-23
Front Matter....Pages 25-25
Extensive Percolation in Reasonable Idiotypic Networks....Pages 26-37
The Concept of Idiotypic Network: Deficient or Premature?....Pages 38-52
Dynamical Behavior of Discrete Models of Jerne’s Network....Pages 53-62
Some Reflections on Memory in Shape Space....Pages 63-70
Front Matter....Pages 71-71
Regulation of the Immune Response: A Discrete Mapping Approach....Pages 72-84
Simulation of the Immune Cellular Response by Small Neural Networks....Pages 85-98
Discrete Time Versus Continuous Time Approach to the Autoimmune Response....Pages 99-106
Optimizing the Immune Control of Parasitic Invasion....Pages 107-115
Back Matter....Pages 117-117

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The immune system may be viewed as a network of interacting cells producing cooperative behavior with the properties of memory and learning. Like the central nervous system, it can be studied as a parallel computing network, endowed with cognitive capabilities. The contributions in this book discuss the various formal approaches available today to analyze the behavior of immune networks. The first part of the book presents empirical data on some molecular and cellular interactions, mainly idiotypic-antiidiotypic, which constitute the substrate for the connections between different cell populations. Automata network behavior can be used to model not only idiotypic-antiidiotypic interactions but also other interactions between different classes of lymphocytes as well as receptor-antigen interactions. Thus the concept of immune networks receives a more precise meaning. Two different approaches are then discussed. Part two discusses the "large" network approach made of all possible idiotypic-antiidiotypic interactions with cross-reactivity. Part three discusses the small network approach, better fitted to represent and analyze specific data on limited interactions. The book presents the first applications of neural network computation to immunology.
Content:
Front Matter....Pages I-VIII
Introduction to Immune Networks....Pages 1-3
Front Matter....Pages 5-5
Natural Id-Anti-Id Networks and the Immunological Homunculus....Pages 6-12
Self-Nonself Immunological Tolerance and Idiotype Networks....Pages 13-23
Front Matter....Pages 25-25
Extensive Percolation in Reasonable Idiotypic Networks....Pages 26-37
The Concept of Idiotypic Network: Deficient or Premature?....Pages 38-52
Dynamical Behavior of Discrete Models of Jerne’s Network....Pages 53-62
Some Reflections on Memory in Shape Space....Pages 63-70
Front Matter....Pages 71-71
Regulation of the Immune Response: A Discrete Mapping Approach....Pages 72-84
Simulation of the Immune Cellular Response by Small Neural Networks....Pages 85-98
Discrete Time Versus Continuous Time Approach to the Autoimmune Response....Pages 99-106
Optimizing the Immune Control of Parasitic Invasion....Pages 107-115
Back Matter....Pages 117-117
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