Ebook: Prediction of Protein Structure and the Principles of Protein Conformation

The prediction of the conformation of proteins has developed from an intellectual exercise into a serious practical endeavor that has great promise to yield new stable enzymes, products of pharmacological significance, and catalysts of great potential. With the application of predic­ tion gaining momentum in various fields, such as enzymology and immunology, it was deemed time that a volume be published to make available a thorough evaluation of present methods, for researchers in this field to expound fully the virtues of various algorithms, to open the field to a wider audience, and to offer the scientific public an opportunity to examine carefully its successes and failures. In this manner the practitioners of the art could better evaluate the tools and the output so that their expectations and applications could be more realistic. The editor has assembled chapters by many of the main contributors to this area and simultaneously placed their programs at three national resources so that they are readily available to those who wish to apply them to their personal interests. These algorithms, written by their originators, when utilized on pes or larger computers, can instantaneously take a primary amino acid sequence and produce a two-or three-dimensional artistic image that gives satisfaction to one's esthetic sensibilities and food for thought concerning the structure and function of proteins. It is in this spirit that this volume was envisaged.

---

---

Content:
Front Matter....Pages i-xiii
Principles and Patterns of Protein Conformation....Pages 1-98
The Structure of the Photochemical Reaction Center of Rhodopseudomonas viridis and Its Implications for Function....Pages 99-116
Virus Structure....Pages 117-148
Protein Stability and Function....Pages 149-159
Stabilization Energies of Protein Conformation....Pages 161-192
The Development of the Prediction of Protein Structure....Pages 193-316
The Role of Energy Minimization in Simulation Strategies of Biomolecular Systems....Pages 317-358
The Role of Electrostatic Interactions in the Structure of Globular Proteins....Pages 359-389
Chou-Fasman Prediction of the Secondary Structure of Proteins....Pages 391-416
The GOR Method for Predicting Secondary Structures in Proteins....Pages 417-465
Prediction of Packing of Secondary Structure....Pages 467-548
Prediction of Protein Structural Classes from Amino Acid Compositions....Pages 549-586
Use of Class Prediction to Improve Protein Secondary Structure Prediction....Pages 587-597
Redundancies in Protein Sequences....Pages 599-623
The Hydrophobicity Profile....Pages 625-633
Hydrophobic Moments as Tools for Analyzing Protein Sequences and Structures....Pages 635-646
Tertiary Structure Prediction....Pages 647-705
Structure Prediction for Membrane Proteins....Pages 707-717
Identification of Membrane Proteins and Soluble Protein Secondary Structural Elements, Domain Structure, and Packing Arrangements by Fourier-Transform Amphipathic Analysis....Pages 719-759
Guide for Studies on Structure and Function Employing Synthetic Polypeptides....Pages 761-775
Back Matter....Pages 777-798

---

Content:
Front Matter....Pages i-xiii
Principles and Patterns of Protein Conformation....Pages 1-98
The Structure of the Photochemical Reaction Center of Rhodopseudomonas viridis and Its Implications for Function....Pages 99-116
Virus Structure....Pages 117-148
Protein Stability and Function....Pages 149-159
Stabilization Energies of Protein Conformation....Pages 161-192
The Development of the Prediction of Protein Structure....Pages 193-316
The Role of Energy Minimization in Simulation Strategies of Biomolecular Systems....Pages 317-358
The Role of Electrostatic Interactions in the Structure of Globular Proteins....Pages 359-389
Chou-Fasman Prediction of the Secondary Structure of Proteins....Pages 391-416
The GOR Method for Predicting Secondary Structures in Proteins....Pages 417-465
Prediction of Packing of Secondary Structure....Pages 467-548
Prediction of Protein Structural Classes from Amino Acid Compositions....Pages 549-586
Use of Class Prediction to Improve Protein Secondary Structure Prediction....Pages 587-597
Redundancies in Protein Sequences....Pages 599-623
The Hydrophobicity Profile....Pages 625-633
Hydrophobic Moments as Tools for Analyzing Protein Sequences and Structures....Pages 635-646
Tertiary Structure Prediction....Pages 647-705
Structure Prediction for Membrane Proteins....Pages 707-717
Identification of Membrane Proteins and Soluble Protein Secondary Structural Elements, Domain Structure, and Packing Arrangements by Fourier-Transform Amphipathic Analysis....Pages 719-759
Guide for Studies on Structure and Function Employing Synthetic Polypeptides....Pages 761-775
Back Matter....Pages 777-798
....