Ebook: Free Energy Transduction and Biochemical Cycle Kinetics

This small book is a simplified, abbreviated, and updated version of the author's Free Energy Transduction in Biology, published in 1977 (Academic Press, New York). The present book is meant to be a textbook for a class or for self-study. The first chapter gives a self-contained and elementary discussion of the principles of free energy transduction in biology. Section 5 includes new material on the Onsager coefficients Lij (for systems near equilibrium) not avail­ able in 1977. Some readers may wish to study the first chapter only. The second chapteris a little more sophisticated, and deals with the so-called diagram method for calculating steady-state probabili­ ties and cycle fluxes. Although these concepts are useful in the analysis of free energy transduction systems, they have an intrinsic importance and interest. Section 8 summarizes quite recent new results not included in the 1977 book. The third chapter is again a step more sophisticated. Some readers may wish to omit it. Free energy levels of the states in a kinetic diagram are introduced. This topic is primarily of conceptual inter­ est for ordinary kinetic diagrams but it is essential in understanding muscle contraction (and related systems) at the molecular level. Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii . . . . . . . . . . . . . . . . Chapter 1 Survey of the Elements of Free Energy Transduction. . . . . . . . . . . . . .. . . . . . . . . . 1 1. States, Diagrams, Cycles, and Free Energy Transduction ...................... 2 2. Thermodynamic Forces. . . . . . . . . . . . . . . . 12 . . . . 3. Operational, Cycle, and Transition Fluxes. . . . . 20 4. Efficiency and the Rate of Free Energy Dissipation . . . . . . . . . . . . . . . . . . 24 . . . . . .

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With this brief and updated textbook, Dr. Hill wants to explain in much simpler language than was possible in his prior research monographs the theory of free energy transfer in biology, and finally make it accessible to students and investigators entering this field. It is designed for an upper-level class in biochemistry or biophysics and can also be used for self-study.

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With this brief and updated textbook, Dr. Hill wants to explain in much simpler language than was possible in his prior research monographs the theory of free energy transfer in biology, and finally make it accessible to students and investigators entering this field. It is designed for an upper-level class in biochemistry or biophysics and can also be used for self-study.
Content:
Front Matter....Pages i-viii
Survey of the Elements of Free Energy Transduction....Pages 1-37
State Probabilities and Fluxes in Terms of the Rate Constants of the Diagram....Pages 39-88
Free Energy Levels and Application to Muscle Contraction....Pages 89-115
Back Matter....Pages 117-119

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With this brief and updated textbook, Dr. Hill wants to explain in much simpler language than was possible in his prior research monographs the theory of free energy transfer in biology, and finally make it accessible to students and investigators entering this field. It is designed for an upper-level class in biochemistry or biophysics and can also be used for self-study.
Content:
Front Matter....Pages i-viii
Survey of the Elements of Free Energy Transduction....Pages 1-37
State Probabilities and Fluxes in Terms of the Rate Constants of the Diagram....Pages 39-88
Free Energy Levels and Application to Muscle Contraction....Pages 89-115
Back Matter....Pages 117-119
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