Ebook: Mutation, Cancer, and Malformation

During the early 1930s, when I was a graduate student and later a post-doctoral researcher at the National Research Council for the University of Wisconsin at Madison, we had the opportunity to get acquainted with many graduate students from China who were sent to the University for training in modern basic sciences as well as social sciences. The University of Wisconsin continues to graduate a large number of Chinese students. Economic conditions in the 1930s were very precarious for the United States and other parts of the world. Many of us students grew closer together because we were living on similarly tight budgets. As a matter of fact, we subleased a part of our apartment in Madison to some Chinese graduate students. This was a very nice opportunity for us to learn about the scientific and cultural back­ ground of our Chinese friends. Many of them came from the interior of China and had had very little opportunity to become acquainted with people from a western culture. Living with these students was a very pleasant and educational experience which gave us a good pic­ ture of the cultural life and educational system of China at that time--an intimate picture that one normally would not see without travelling in that country.

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Content:
Front Matter....Pages i-xiv
Environmental Mutagenesis and Disease in Human Populations....Pages 1-11
Clinical Genetics of Human Cancer....Pages 13-34
Chromosome Abnormalities in Cancer Development....Pages 35-59
Mutations of Cellular Oncogenes as a Basis for Neoplastic Change....Pages 61-77
Human Gene Mapping in the Analysis of Oncogenes....Pages 79-95
Relationship between Mutagenesis and Carcinogenesis....Pages 97-112
Theoretical Basis of Mutagenesis....Pages 113-155
DNA Repair Processes....Pages 157-166
The Role of DNA Repair in Mutation Induction....Pages 167-196
Mutagenesis in Yeasts....Pages 197-216
The P-Factor: A Transposable Element in Drosophila....Pages 217-232
Silkworm Genetics and Chemical Mutagenesis....Pages 233-255
Mutagenesis Studies with Cultured Mammalian Cells: Problems and Prospects....Pages 257-273
The Control of Cell Transformation, Mutagenesis, and Differentiation by Chemicals that Initiate or Promote Tumor Formation....Pages 275-283
Dominant-Lethal Mutations and Heritable Translocations in Mice....Pages 285-313
Recessive and Dominant Mutations in Mice....Pages 315-346
Benzo (a) Pyrene and 6-Nitrobenzo (a) Pyrene Metabolism in Human and Rodent Microsomes and Tissue Culture....Pages 347-367
Nitrosamine Metabolism and Carcinogenesis....Pages 369-388
Modification of Carcinogenesis by Dietary and Nutritional Factors....Pages 389-428
Naturally Occurring Mutagens....Pages 429-446
Teratogenesis....Pages 447-464
A Possible Mechanistic Link between Teratogenesis and Carcinogenesis: Inhibited Intercellular Communication....Pages 465-485
Germ Cell Toxicity: Significance in Genetic and Fertility Effects of Radiation and Chemicals....Pages 487-498
The Science of Toxicology-Scope, Goals and Four Case Studies....Pages 499-527
Mutagenicity of Pesticides....Pages 529-547
Genetic Toxicology of 14 Agents Causally Associated with Cancer in Humans....Pages 549-590
Sensitivity, Specificity and Accuracy of the Arabidopsis Assay in the Identification of Carcinogens....Pages 591-616
Environmental Studies in Sweden....Pages 617-624
Research Progress on Environmental Mutagenesis, Carcinogenesis and Teratogenesis in China....Pages 625-687
A Strategy of Approach to Cancer Control in China....Pages 689-708
Toxicological Research in Public Health: The Chinese Experience....Pages 709-721
Environmental Mutagenesis Research at Fudan University....Pages 723-734
The Role of Risk Assessment in Regulatory Decisions in the United States....Pages 735-744
Alternate Methods for Integrated Evaluation of Toxicity and Risk Assessment....Pages 745-754
Lymphocyte Chromosome Aberrations in Persons Exposed to Low Levels of Radiation....Pages 755-769
Cytogenetic Follow-Up Studies in Persons Accidentally Exposed to 60Co ?-Rays, 10 Years After Exposure....Pages 771-785
Studies on Micronucleus Test by Human Skin Puncture....Pages 787-810
Comparison of the Responses of the Micronucleus Test in Different Strains of Mice....Pages 811-811
Study on the Micronucleus in Nucleated Erythrocytes in Vertebrates and its Application to Monitoring Environmental Pollution....Pages 812-812
Chromosome Aberrations in Human Lymphocytes Induced by Tritium....Pages 812-813
Induction of Sister Chromatid Exchanges with “Compound Presciption Progestogen No. 1” in the Maternal and Embryonic Tissues of Mice....Pages 813-814
The Influence of Oral Contraceptive on Silver-Stained Acrocentric Association....Pages 814-814
The Induction of Sister Chromatid Exchanges in Human Gastric Carcinoma Cells and Lymphocytes Exposed to Anti-Tumor Drugs....Pages 815-815
Influence of 2450 MHz Microwave Radiation on Sister Chromatid Exchange (SCE) of Human Lymphocytes in Short Term Culture....Pages 816-816
Effects of Several Kinds of Radiosensitizers on ?-Ray-Induced DNA Single Strand Breaks and their Rejoining in Mammalian Cells....Pages 816-817
Effects of Interferon on Mitomycin-Induced Sister Chromatid Exchanges and on Ultraviolet-Light-Induced Unscheduled DNA Synthesis....Pages 817-818
Isolation and Identification of Direct-Acting Mutagens in Diesel Exhaust....Pages 818-819
Aphidicolin Induces Endoreduplication in Chinese Hamster Cells....Pages 819-819
Search for Carcinogenic Agents in the Shanghai Rubber Industry....Pages 819-820
Induction of Lung Cancer in Wistar Rats by Tin Ore Dust Containing Arsenicals....Pages 820-821
Carcinogenicity of Extract of Soot from Xuan Wei County after Administering Subcutaneously to Mice....Pages 821-821
Study on the Carcinogenicity of Chlordimeform III. Long-Term Feeding Assay in Mice....Pages 821-822
Induction of Tumor in the Progeny of Dinitrosopiperazine-Treated Pregnant Rats....Pages 822-822
Promoting Effect and Related Actions of TPA on C3H/10T1/2 Cells....Pages 823-823
Study of Carcinogenic Mechanism for Polycyclic Aromatic Hydrocarbons: Extended Bay Region Theory and Its Quantitative Model....Pages 823-824
Epidemiological Survey on the Teratogenic Effect of MATDA [Methylene-Bis-(2-Amino-1,3,4-Thiadiazole)]....Pages 824-824
Mutagenicity and Teratogenicity of the Fungicide Ethyl Disulfide....Pages 825-825
The Frequency of Sister Chromatid Exchange in Peripheral Lymphocytes of Workers Exposed to TNT....Pages 826-826
Studies on the Malignant Transformation of Mouse Bone Marrow Cells In Vitro Induced by 60Co ?-Ray Irradiation....Pages 826-827
Dominant Lethal Mutations Induced by Tritiated Water and 60Co Gamma Rays in Female Mice....Pages 828-828
Inhibitory Effects of Phenolic or Hydroxy Compounds on the Metabolism of Benzo(a)Pyrene....Pages 828-829
A Preliminary Observation on the Mutagenic Effect of Dibromochloropropane (DBCP) in Drosophila Melanogaster Sex-Linked Recessive Lethal Test....Pages 829-830
Lung Cancer and Exposure to Chloro-Methyl-Ethers —An Occupational Epidemiological Survey....Pages 830-830
Studies on the Mutagenicity and Teratogenicity of Methyl-Parathion....Pages 831-831
Study on the Carcinogenecity of ?-Benzene-Hexachloride in Rats....Pages 831-832
Back Matter....Pages 832-833
....Pages 833-834