Ebook: Application of Biological Markers to Carcinogen Testing

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Content:
Front Matter....Pages i-xi
Welcoming Remarks....Pages 1-2
An Overview of Current Research Efforts on the Application of Biological Markers to Carcinogen Testing....Pages 3-5
Chairman’s Overview on In Vivo Tests....Pages 7-8
The Occurrence Of Neoplasms in Long-Term in Vivo Studies....Pages 9-23
Markers of Liver Neoplasia — Real or Fictional?....Pages 25-42
Early Morphologic Markers of Carcinogenicity in Rat Pancreas....Pages 43-60
Rodent and Human Models For the Analysis of Intestinal Tumor Development....Pages 61-89
Effect Of Diet On Intestinal Tumor Production....Pages 91-107
Tumor Antigens As Markers For Carcinogens....Pages 109-115
Chairmen’s Overview on in Vitro Tests....Pages 117-118
Biochemistry and Biology of 2-Acetyl-Aminofluorene in Primary Cultures of Adult Rat Hepatocytes....Pages 119-133
Relating in Vitro Assays of Carcinogen-Induced Genotoxicity to Transformation of Diploid Human Fibroblasts....Pages 135-152
Evaluation of Chronic Rodent Bioassays and Ames Assay Tests as Accurate Models for Predicting Human Carcinogens....Pages 153-163
Indices for Identification of Genotoxic and Epigenetic Carcinogens in Cell Culture....Pages 165-175
Chairmen’s Overview on Enzyme Markers....Pages 177-178
Aryl Hydrocarbon Hydroxylase Activity “Of Mice and Humans”....Pages 179-197
Gamma-Glutamyl Transpeptidase Expression in Neoplasia and Development....Pages 199-220
Ornithine Decarboxylase: Alterations In Carcinogenesis....Pages 221-228
Human Tumors: Enzyme Activities And Isozyme Profiles....Pages 229-247
Enzyme and Isoenzyme Patterns as Potential Markers of Neoplasia in Breast Tissue....Pages 249-265
Chairmen’s Overview On Oncodevelopmental Markers....Pages 267-269
Alphafetoprotein as a Marker for Early Events and Carcinoma Development During Chemical Hepatocarcinogenesis....Pages 271-293
Human Chorionic Gonadotropin and its Subunits as Tumor Markers....Pages 295-311
Prostaglandins and Cancer....Pages 313-319
Chairmen’s Overview on the Use of Immunoanalytical Method for the Characterization and Quantification of DNA Components Structurally Modified by Carcinogens and Mutagens....Pages 321-324
Immunological Approaches for the Detection of DNA Modified by Environmental Agents....Pages 325-336
Detection of Thymine Dimers in DNA with Monoclonal Antibodies....Pages 337-348
Immunological Studies on the Influence of Chromatin Structure on the Binding of a Chemical Carcinogen to the Genome....Pages 349-371
High-Affinity Monoclonal Antibodies Specifically Directed Against DNA Components Structurally Modified by Alkylating N-Nitroso Compounds....Pages 373-385
Charimen’s Overview on Carcinogen-Induced Modification in DNA....Pages 387-388
Use of Repair-Deficient Mammalian Cells for the Identification of Carcinogens....Pages 389-402
Thymine Modifications in DNA as Markers of Radiation Exposure....Pages 403-415
Aberrant Methylation of DNA As an Effect of Cytotoxic Agents....Pages 417-426
Identification of Carcinogen-DNA Adducts by Immunoassays....Pages 427-440
Chairman’s Overview on Integration and Expression of the Polyoma Virus Oncogenes In Transformed Cells....Pages 441-452
Activation of Cellular Onc (C-ONC) Genes: A Common Pathway for Oncogenesis....Pages 453-463
Hepatitis B Virus as an Environmental Carcinogen....Pages 465-473
Research Needs on the Use of Tumor Markers in the Identification of Chemical Carcinogens....Pages 475-487
The Polypeptides of the Cytosol of Hepatocyte Nodules may Exhibit a Unique Electrophoretic Pattern....Pages 489-489
Rat Alloantigens as Cellular Markers for Hepatocytes in Genotypic Mosaic Livers During Chemically Induced Hepatocarcinogenesis....Pages 490-490
Metabolic Considerations in the Toxicity and Mutagenicity of the Nitronaphthalenes....Pages 491-492
Detection and Identification of Common Oncofetal Antigens on in Vitro Transformed Mouse Fibroblasts....Pages 493-493
Inhibition of Metabolic Cooperation Between Cultured Mammalian Cells by Selected Tumor Promoters, Chemical Carcinogens, and Other Compounds....Pages 494-495
A Rapid in Vitro Assay for Detecting Phorbol Ester-Like Tumor Promoters....Pages 496-497
Induction of Endogenous Murine Retrovirus by Chemical Carcinogens....Pages 498-498
Evaluation of Known Genotoxic Agents and ?9-Tetrahydrocannabinol for SCE Induction by the Intraperitoneal 5-Bromo-2’-Deoxyuridine Infusion Technique for Sister Chromatid Exchange Visualization....Pages 499-500
Effect of 2,3-Oxide-3,3,3-Trichloropropane on BaP Metabolism in Mullet....Pages 501-502
The Effect of Dimethylbenzanthracene on the NK Activity of Mice....Pages 503-503
Back Matter....Pages 504-505
....Pages 507-516