Ebook: Cellular and Molecular Aspects of Implantation

Long was I hugg'd close-long and long. Immense have been the preparations for me, Faithful and friendly the arms that have help'd me. Cycles ferried my cradle, rowing and rowing like friendly boatmen. For room to me stars kept aside in their own rings, They sent influences to look after what was to hold me. Before I was born out of my mother, generations guided me, My embryo has never been torpid, nothing could overlay it. -Walt Whitman, "Song of Myself" The womb is the seat of all mammalian life. In pregnancy, the uterus acquires this impor­ tance with the arrival of the fertilized egg, which takes up residence for periods ranging from about 2 weeks in the opossum to about 2 years in the elephant. The arrival of the embryo signals a crucial time for the establishment of pregnancy. For several days the blas­ tocyst remains free in the uterine lumen, where it depends on uterine secretions for its sur­ vival and differentiation. During this time, essential changes in the endometrium take place in preparation for attachment of the blastocyst and implantation. Early embryonic loss is an economic problem of global proportions in animal husbandry, where, in pigs and cattle for example, some 30% of all fertilizations fail to result in a pregnancy. In humans this figure may be even higher, and estimates of early spontaneous abortions range from 40 to 60% of all conceptions.

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Content:
Front Matter....Pages i-xxi
Front Matter....Pages 1-1
Viviparity....Pages 3-25
My Life with Mammalian Eggs....Pages 27-36
Front Matter....Pages 37-37
Introduction....Pages 39-42
The Origin of Trophoblast and Its Role in Implantation....Pages 43-54
The Generation and Recognition of Positional Information in the Preimplantation Mouse Embryo....Pages 55-74
Relationship between the Programs for Implantation and Trophoblast Differentiation....Pages 75-89
Cellular and Genetic Analysis of Mouse Blastocyst Development....Pages 91-108
Front Matter....Pages 109-109
Introduction....Pages 111-112
Mobilization of Genetic Information in the Early Rabbit Trophoblast....Pages 113-124
Activity of RNA and DNA Polymerases in Delayed-Implanting Mouse Embryos....Pages 125-136
A Reexamination of Messenger RNA Populations in the Preimplantation Mouse Embryo....Pages 137-154
Intrinsic and Extrinsic Patterns of Molecular Differentiation during Oogenesis, Embryogenesis, and Organogenesis in Mammals....Pages 155-176
Front Matter....Pages 177-177
Introduction....Pages 179-180
Cell Proliferation and Cell Death in the Endometrium....Pages 181-195
Shifts in Uterine Stromal Cell Populations during Pregnancy and Regression....Pages 197-216
Separated Cell Types as Analytical Tools in the Study of Decidualization and Implantation....Pages 217-239
Decidual Cell Function Role of Steroid Hormones and Their Receptors....Pages 241-252
Front Matter....Pages 253-253
Introduction....Pages 255-256
Mechanisms of Induction of Uterine Protein Synthesis Hormonal Regulation of Uteroglobin....Pages 257-268
Regulation of the Levels of mRNA for Glucose-6-phosphate Dehydrogenase and Its Rate of Translation in the Uterus by Estradiol....Pages 269-281
Front Matter....Pages 253-253
Uterine DNA Polymerase Acquisition of Responsiveness to Estrogen during Postnatal Development of the Rat....Pages 283-290
The Artificially Stimulated Decidual Cell Reaction in the Mouse Uterus Studies of RNA Polymerases and Histone Modifications....Pages 291-306
Front Matter....Pages 307-307
Introduction....Pages 309-310
Embryonic Signals and Maternal Recognition....Pages 311-326
Uterine Blastotoxic Factors....Pages 327-334
Lysosomal Mechanisms in Blastocyst Implantation and Early Decidualization....Pages 335-344
Front Matter....Pages 345-345
Introduction....Pages 347-348
The Role of Prostaglandins in Endometrial Vascular Changes at Implantation....Pages 349-363
Comparison of Implantation in Utero and in Vitro....Pages 365-382
Time-Lapse Cinematography of Mouse Embryo Development from Blastocysts to Early Somite Stage....Pages 383-392
Front Matter....Pages 393-393
The Effects of Estradiol-17 ? and Progesterone on the Volume of Uterine Fluid in Ovariectomized Mice....Pages 395-397
Presence of hCG-like Material in the Preimplantation Rabbit Blastocyst....Pages 398-400
Electron Microscopic Study of Rat ? Mouse Chimeric Blastocysts Produced by Embryo Aggregation....Pages 401-403
Characteristics of an Endogenous Inhibitor of Progesterone Binding in Rat Trophoblast....Pages 404-406
Histone Synthesis in Preimplantation Mouse Embryos....Pages 407-408
Use of Concanavalin A to Monitor Changes in Glycoprotein Synthesis during Early Mouse Development....Pages 409-411
The Role of Glycoproteins in the Development of Preimplantation Mouse Embryos....Pages 412-414
The Role of Blastolemmase in Implantation Initiation in the Rabbit....Pages 415-416
Estradiol-17 ? Dehydrogenase in Rat Endometrium at the Time of Implantation....Pages 417-419
The Pig Uterus Secretes a Progesterone-Induced Inhibitor of Plasminogen Activator....Pages 420-422
Front Matter....Pages 393-393
Role of a Uterine Endopeptidase in the Implantation Process of the Rat....Pages 423-427
The Role of Prostaglandins and Cyclic Nucleotides in the Artifically Stimulated Decidual Cell Reaction in the Mouse Uterus....Pages 428-430
Inhibitory Effect of Indomethacin on Nuclear Binding of Progesterone in the Uterus and on Differentiation of Decidual Cells in Culture....Pages 431-433
Maternal Recognition of Pregnancy in Swine....Pages 434-435
Effects of Preimplantation Bovine and Porcine Conceptuses on Blood Flow and Steroid Content of the Uterus....Pages 436-438
Effects of Nicotine on Conceptus Cell Proliferation and Oviductal/Uterine Blood Flow in the Rat....Pages 439-442
The Uterine Epithelium as a Transducer for the Triggering of Decidualization in the Rat....Pages 443-445
Cellular Contact between the Trophoblast and the Endometrium at Implantation in the Ewe....Pages 446-449
Cell Motility and the Distribution of Actin and Myosin during Mouse Trophoblast Development in Vitro....Pages 450-453
Autoradiographic Studies of Mouse Uterine Glands during the Periimplantation Period....Pages 454-456
In Vitro Attachment and Outgrowth of Mouse Trophectoderm....Pages 457-460
Hormone Production by Rat Blastocysts and Midpregnancy Trophoblasts in Vitro....Pages 461-463
Separation and Characterization of Endocervical Cells....Pages 464-466
Role of the Major Histocompatibility Complex in the Timing of Early Mammalian Development....Pages 467-470
Pregnancy-Associated Endometrial Protein in Women....Pages 471-472
Survival of Rat Blastocysts in the Uterus of the Mouse Following Xenogeneic Implantation....Pages 473-475
Concanavalin-A-Binding Capacity of Preimplantation Mouse Embryos....Pages 476-477
The Use of Pharmacological Agents to Study Implantation....Pages 478-479
Back Matter....Pages 481-497

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Content:
Front Matter....Pages i-xxi
Front Matter....Pages 1-1
Viviparity....Pages 3-25
My Life with Mammalian Eggs....Pages 27-36
Front Matter....Pages 37-37
Introduction....Pages 39-42
The Origin of Trophoblast and Its Role in Implantation....Pages 43-54
The Generation and Recognition of Positional Information in the Preimplantation Mouse Embryo....Pages 55-74
Relationship between the Programs for Implantation and Trophoblast Differentiation....Pages 75-89
Cellular and Genetic Analysis of Mouse Blastocyst Development....Pages 91-108
Front Matter....Pages 109-109
Introduction....Pages 111-112
Mobilization of Genetic Information in the Early Rabbit Trophoblast....Pages 113-124
Activity of RNA and DNA Polymerases in Delayed-Implanting Mouse Embryos....Pages 125-136
A Reexamination of Messenger RNA Populations in the Preimplantation Mouse Embryo....Pages 137-154
Intrinsic and Extrinsic Patterns of Molecular Differentiation during Oogenesis, Embryogenesis, and Organogenesis in Mammals....Pages 155-176
Front Matter....Pages 177-177
Introduction....Pages 179-180
Cell Proliferation and Cell Death in the Endometrium....Pages 181-195
Shifts in Uterine Stromal Cell Populations during Pregnancy and Regression....Pages 197-216
Separated Cell Types as Analytical Tools in the Study of Decidualization and Implantation....Pages 217-239
Decidual Cell Function Role of Steroid Hormones and Their Receptors....Pages 241-252
Front Matter....Pages 253-253
Introduction....Pages 255-256
Mechanisms of Induction of Uterine Protein Synthesis Hormonal Regulation of Uteroglobin....Pages 257-268
Regulation of the Levels of mRNA for Glucose-6-phosphate Dehydrogenase and Its Rate of Translation in the Uterus by Estradiol....Pages 269-281
Front Matter....Pages 253-253
Uterine DNA Polymerase Acquisition of Responsiveness to Estrogen during Postnatal Development of the Rat....Pages 283-290
The Artificially Stimulated Decidual Cell Reaction in the Mouse Uterus Studies of RNA Polymerases and Histone Modifications....Pages 291-306
Front Matter....Pages 307-307
Introduction....Pages 309-310
Embryonic Signals and Maternal Recognition....Pages 311-326
Uterine Blastotoxic Factors....Pages 327-334
Lysosomal Mechanisms in Blastocyst Implantation and Early Decidualization....Pages 335-344
Front Matter....Pages 345-345
Introduction....Pages 347-348
The Role of Prostaglandins in Endometrial Vascular Changes at Implantation....Pages 349-363
Comparison of Implantation in Utero and in Vitro....Pages 365-382
Time-Lapse Cinematography of Mouse Embryo Development from Blastocysts to Early Somite Stage....Pages 383-392
Front Matter....Pages 393-393
The Effects of Estradiol-17 ? and Progesterone on the Volume of Uterine Fluid in Ovariectomized Mice....Pages 395-397
Presence of hCG-like Material in the Preimplantation Rabbit Blastocyst....Pages 398-400
Electron Microscopic Study of Rat ? Mouse Chimeric Blastocysts Produced by Embryo Aggregation....Pages 401-403
Characteristics of an Endogenous Inhibitor of Progesterone Binding in Rat Trophoblast....Pages 404-406
Histone Synthesis in Preimplantation Mouse Embryos....Pages 407-408
Use of Concanavalin A to Monitor Changes in Glycoprotein Synthesis during Early Mouse Development....Pages 409-411
The Role of Glycoproteins in the Development of Preimplantation Mouse Embryos....Pages 412-414
The Role of Blastolemmase in Implantation Initiation in the Rabbit....Pages 415-416
Estradiol-17 ? Dehydrogenase in Rat Endometrium at the Time of Implantation....Pages 417-419
The Pig Uterus Secretes a Progesterone-Induced Inhibitor of Plasminogen Activator....Pages 420-422
Front Matter....Pages 393-393
Role of a Uterine Endopeptidase in the Implantation Process of the Rat....Pages 423-427
The Role of Prostaglandins and Cyclic Nucleotides in the Artifically Stimulated Decidual Cell Reaction in the Mouse Uterus....Pages 428-430
Inhibitory Effect of Indomethacin on Nuclear Binding of Progesterone in the Uterus and on Differentiation of Decidual Cells in Culture....Pages 431-433
Maternal Recognition of Pregnancy in Swine....Pages 434-435
Effects of Preimplantation Bovine and Porcine Conceptuses on Blood Flow and Steroid Content of the Uterus....Pages 436-438
Effects of Nicotine on Conceptus Cell Proliferation and Oviductal/Uterine Blood Flow in the Rat....Pages 439-442
The Uterine Epithelium as a Transducer for the Triggering of Decidualization in the Rat....Pages 443-445
Cellular Contact between the Trophoblast and the Endometrium at Implantation in the Ewe....Pages 446-449
Cell Motility and the Distribution of Actin and Myosin during Mouse Trophoblast Development in Vitro....Pages 450-453
Autoradiographic Studies of Mouse Uterine Glands during the Periimplantation Period....Pages 454-456
In Vitro Attachment and Outgrowth of Mouse Trophectoderm....Pages 457-460
Hormone Production by Rat Blastocysts and Midpregnancy Trophoblasts in Vitro....Pages 461-463
Separation and Characterization of Endocervical Cells....Pages 464-466
Role of the Major Histocompatibility Complex in the Timing of Early Mammalian Development....Pages 467-470
Pregnancy-Associated Endometrial Protein in Women....Pages 471-472
Survival of Rat Blastocysts in the Uterus of the Mouse Following Xenogeneic Implantation....Pages 473-475
Concanavalin-A-Binding Capacity of Preimplantation Mouse Embryos....Pages 476-477
The Use of Pharmacological Agents to Study Implantation....Pages 478-479
Back Matter....Pages 481-497
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