Ebook: Computer Models in Biomechanics: From Nano to Macro

This book contains a collection of papers that were presented at the IUTAM Symposium

on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011.

It contains state-of-the-art papers on:

- Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates

- Muscle Mechanics: modeling approaches for Ca^2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling

- Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure

- Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media

- Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

---

This book contains a collection of papers that were presented at the IUTAM Symposium

on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011.

It contains state-of-the-art papers on:

- Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates

- Muscle Mechanics: modeling approaches for Ca^2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling

- Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure

- Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media

- Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

---

This book contains a collection of papers that were presented at the IUTAM Symposium

on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011.

It contains state-of-the-art papers on:

- Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates

- Muscle Mechanics: modeling approaches for Ca^2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling

- Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure

- Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media

- Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

Content:
Front Matter....Pages I-XI
Front Matter....Pages 1-1
Towards a Coarse-Grained Model for Unfolded Proteins....Pages 3-10
Modeling Collagen-Proteoglycan Structural Interactions in the Human Cornea....Pages 11-24
Simulations of Cell Behavior on Substrates of Variegated Stiffness and Architecture....Pages 25-41
Front Matter....Pages 43-43
A Mathematical Approach for Studying Ca2+-Regulated Smooth Muscle Contraction....Pages 45-62
A Coupled Chemomechanical Model for Smooth Muscle Contraction....Pages 63-75
Modeling of Smooth Muscle Activation....Pages 77-89
A Cross-Bridge Model Describing the Mechanoenergetics of Actomyosin Interaction....Pages 91-102
Multiscale Skeletal Muscle Modeling: From Cellular Level to a Multi-segment Skeletal Muscle Model of the Upper Limb....Pages 103-116
Front Matter....Pages 117-117
Multiscale Modeling of Arterial Adaptations: Incorporating Molecular Mechanisms Within Continuum Biomechanical Models....Pages 119-127
Cardiovascular Tissue Damage: An Experimental and Computational Framework....Pages 129-148
Mechanical Properties of Ascending Thoracic Aortic Aneurysm (ATAA): Association with Valve Morphology....Pages 149-160
Intracranial Aneurysms: Modeling Inception and Enlargement....Pages 161-173
Micro-structurally Based Kinematic Approaches to Electromechanics of the Heart....Pages 175-187
Activation Models for the Numerical Simulation of Cardiac Electromechanical Interactions....Pages 189-201
Hemodynamic Alterations Associated with Coronary and Cerebral Arterial Remodeling Following a Surgically-Induced Aortic Coarctation....Pages 203-216
Patient-Specific Surgery Planning for the Fontan Procedure....Pages 217-228
Front Matter....Pages 229-229
Finite Element Modeling of Solutes in Hydrated Deformable Biological Tissues....Pages 231-249
Reformulation of Mixture Theory-Based Poroelasticity for Interstitial Tissue Growth....Pages 251-261
Constitutive and Computational Aspects in Tumor Therapies of Multiphasic Brain Tissue....Pages 263-276
A Biphasic 3D-FEM Model for the Remodeling of Microcirculation in Liver Lobes....Pages 277-292
Front Matter....Pages 229-229
Multiphysics Modeling of Reactions, Mass Transport and Mechanics of Tumor Growth....Pages 293-303
Multicompartmental Poroelasticity as a Platform for the Integrative Modeling of Water Transport in the Brain....Pages 305-316
Discontinuous Versus Continuous Chemical Potential Across a Crack in a Swelling Porous Medium....Pages 317-334
Front Matter....Pages 335-335
Mechanisms of Brain Morphogenesis....Pages 337-349
A Micromechanical Viscoelastic Constitutive Model for Native and Engineered Anterior Cruciate Ligaments....Pages 351-363
Mechanical Characterization of the Human Liver....Pages 365-382
In Vivo Validation of Predictive Models for Bone Remodeling and Mechanobiology....Pages 383-394
Bridging Scales in Respiratory Mechanics....Pages 395-407
Back Matter....Pages 409-413

---

This book contains a collection of papers that were presented at the IUTAM Symposium

on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011.

It contains state-of-the-art papers on:

- Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates

- Muscle Mechanics: modeling approaches for Ca^2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling

- Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure

- Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media

- Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

Content:
Front Matter....Pages I-XI
Front Matter....Pages 1-1
Towards a Coarse-Grained Model for Unfolded Proteins....Pages 3-10
Modeling Collagen-Proteoglycan Structural Interactions in the Human Cornea....Pages 11-24
Simulations of Cell Behavior on Substrates of Variegated Stiffness and Architecture....Pages 25-41
Front Matter....Pages 43-43
A Mathematical Approach for Studying Ca2+-Regulated Smooth Muscle Contraction....Pages 45-62
A Coupled Chemomechanical Model for Smooth Muscle Contraction....Pages 63-75
Modeling of Smooth Muscle Activation....Pages 77-89
A Cross-Bridge Model Describing the Mechanoenergetics of Actomyosin Interaction....Pages 91-102
Multiscale Skeletal Muscle Modeling: From Cellular Level to a Multi-segment Skeletal Muscle Model of the Upper Limb....Pages 103-116
Front Matter....Pages 117-117
Multiscale Modeling of Arterial Adaptations: Incorporating Molecular Mechanisms Within Continuum Biomechanical Models....Pages 119-127
Cardiovascular Tissue Damage: An Experimental and Computational Framework....Pages 129-148
Mechanical Properties of Ascending Thoracic Aortic Aneurysm (ATAA): Association with Valve Morphology....Pages 149-160
Intracranial Aneurysms: Modeling Inception and Enlargement....Pages 161-173
Micro-structurally Based Kinematic Approaches to Electromechanics of the Heart....Pages 175-187
Activation Models for the Numerical Simulation of Cardiac Electromechanical Interactions....Pages 189-201
Hemodynamic Alterations Associated with Coronary and Cerebral Arterial Remodeling Following a Surgically-Induced Aortic Coarctation....Pages 203-216
Patient-Specific Surgery Planning for the Fontan Procedure....Pages 217-228
Front Matter....Pages 229-229
Finite Element Modeling of Solutes in Hydrated Deformable Biological Tissues....Pages 231-249
Reformulation of Mixture Theory-Based Poroelasticity for Interstitial Tissue Growth....Pages 251-261
Constitutive and Computational Aspects in Tumor Therapies of Multiphasic Brain Tissue....Pages 263-276
A Biphasic 3D-FEM Model for the Remodeling of Microcirculation in Liver Lobes....Pages 277-292
Front Matter....Pages 229-229
Multiphysics Modeling of Reactions, Mass Transport and Mechanics of Tumor Growth....Pages 293-303
Multicompartmental Poroelasticity as a Platform for the Integrative Modeling of Water Transport in the Brain....Pages 305-316
Discontinuous Versus Continuous Chemical Potential Across a Crack in a Swelling Porous Medium....Pages 317-334
Front Matter....Pages 335-335
Mechanisms of Brain Morphogenesis....Pages 337-349
A Micromechanical Viscoelastic Constitutive Model for Native and Engineered Anterior Cruciate Ligaments....Pages 351-363
Mechanical Characterization of the Human Liver....Pages 365-382
In Vivo Validation of Predictive Models for Bone Remodeling and Mechanobiology....Pages 383-394
Bridging Scales in Respiratory Mechanics....Pages 395-407
Back Matter....Pages 409-413
....