Ebook: Dynamics of Cholinergic Function

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Content:
Front Matter....Pages i-xviii
Cholinergic Systems in the Central Nervous System: Retrospection, Anatomic Distribution, and Functions....Pages 1-10
Cholinergic Neurons and Cholinergic Projections in the Mammalian CNS....Pages 11-21
Cortical Cholinergic Innervation: Distribution and Source in Monkeys....Pages 23-30
Identification of Putative M1 Muscarinic Receptors Using [3H]Pirenzepine: Characterization of Binding and Autoradiographic Localization in Human Stellate Ganglia....Pages 31-41
Neurotransmitters That Act on Cholinergic Magnocellular Forebrain Nuclei Influence Cortical Acetylcholine Output....Pages 43-50
Biochemistry and Immunocytochemistry of Choline Acetyltransferase....Pages 51-63
Autoradiographic Localization of Subtypes of Muscarinic Agonist and Antagonist Binding Sites: Alterations Following CNS Lesions....Pages 65-78
Immunocytochemical Evidence for the Intra-Axonal Transport of nAChR-Like Material in Motor Neurons....Pages 79-91
Lateralization of Cholinergic and Energy Metabolism Related Enzymes in Human Temporal Cortex....Pages 93-98
Reduced Acetylcholine Synthesis in Alzheimer’s Disease is a Clinically Relevant Change....Pages 99-110
Cortical Cholinergic Hypofunction and Behavioral Impairment Produced by Basal Forebrain Lesions in the Rat....Pages 111-121
Clinical Studies of the Cholinergic Deficit in Alzheimer’s Disease....Pages 123-131
Protection and Therapeutic Effect of CDP Choline in Hypocapnic Neurons in Culture....Pages 133-151
The Aging of Cholinergic Synapses: Ontogenesis of Cholinergic Receptors....Pages 153-163
Aging of Cholinergic Synapses: Fiction or Reality?....Pages 165-175
Interactions of Calcium Homeostasis, Acetylcholine Metabolism, Behavior and 3,4-Diaminopyridine during Aging....Pages 177-190
Cholinergic Dysfunction and Memory; Implications for the Development of Animal Models of Aging and Dementia....Pages 191-204
Relationships between Choline Acetyltransferase and Muscarinic Binding in Aging Rodent Brain and in Alzheimer’s Disease....Pages 205-213
Cholinergic Hypofunction and Dementia: Relation of Neuronal Loss in Different Parts of the Nucleus Basalis to Cortical Neuropathological Changes....Pages 215-224
Basal Forebrain Cholinergic Systems in Primate Brain: Anatomical Organization and Role in the Pathology of Aging and Dementia....Pages 225-234
Cell Counts in the Nucleus Basalis of Meynert and the Supraoptic Nucleus in Alzheimer-Diseased Brains....Pages 235-242
Sympathetic Ingrowth: A Result of Cholinergic Nerve Injury in the Adult Mammalian Brain....Pages 243-250
Determinants of Acetylcholine Levels in Aged Rats....Pages 251-259
Elevated Red Cell to Plasma Choline Ratios in Alzheimer’s Disease....Pages 261-271
Plasma and Red Blood Cell Choline in Aging: Rats, Monkeys and Man....Pages 273-282
Human Red Blood Cell Choline in Aging and Senile Dementia: Effects of Precursor Therapy....Pages 283-290
The Use of Positron Emission Tomography for the Evaluation of Choline Metabolism in the Brain of the Rhesus Monkey....Pages 291-301
Cholinergic Mechanisms in Spinal Cord and Muscle....Pages 303-311
Central Acetylcholine and Stress Induced Cardiovascular, Neuroendocrine and Behavioral Changes: Effects of Physostigmine and Neostigmine....Pages 313-323
Muscarinic Supersensitivity of Anterior Pituitary Acth and ?-Endorphin Release in Major Depressive Illness....Pages 325-334
Cholinergic Receptor Binding in the Frontal Cortex of Suicide Victims....Pages 335-341
Membrane Transport of Choline by the Human Erythrocyte: Relationship to Intracellular Choline Content, and Effect of Treatment with Lithium....Pages 343-349
Studies on the Synaptic Function in Muscle after Nerve Crush in Normal and Diabetic Rats....Pages 351-364
Cholinergic Rem Sleep Induction Response as a Marker of Endogenous Depression....Pages 365-374
Stereoselectivity of Some Muscarinic and Antimuscarinic Agents Related to Oxotremorine....Pages 375-383
Affinity and Efficacy of Oxotremorine Analogs at Ileal Muscarinic Receptors....Pages 385-393
Interactions of Alaproclate, a Selective 5HT-Uptake Blocker, with Muscarinic Receptors: In Vivo and In Vitro Studies....Pages 395-404
Presynaptic Muscarinic Receptors: Change of Sensitivity During Long-Term Drug Treatment....Pages 405-413
Characterization of [3H]-Nicotine Binding in Rodent Brain and Comparison with the Binding of Other Labelled Nicotinic Ligands....Pages 415-422
The Cholinergic Ligand Binding Material of Axonal Membranes....Pages 423-428
Do Motor Neurons Contain Functional Prejunctional Cholinoceptors?....Pages 429-437
Pharmacological Characterization of Axonally Transported [125I]-?-Bungarotoxin Binding Sites in Rat Sciatic Nerve....Pages 439-446
Nicotinic Cholinergic Receptors Labeled with [3H]Acetylcholine in Brain: Characterization, Localization and In Vivo Regulation....Pages 447-457
Resting Release of Acetylcholine at the Motor Endplate....Pages 459-466
Evoked Release of Acetylcholine at the Motor Endplate....Pages 467-479
Depolarization Induced Hydrolysis of Cytoplasmic ACh in Mouse Brain....Pages 481-487
Separation of Recycling and Reserve Synaptic Vesicles from Cholinergic Nerve Terminals of the Myenteric Plexus of Guinea-Pig Ileum....Pages 489-497
Biochemical Implications of the Synaptic Vesicle Organization in Quick Frozen Electric Organ Nerve Terminals....Pages 499-507
Presynaptic Changes Accompanying Transmission of a Single Nerve Impulse: An Interdisciplinary Approach Using Rapid Freezing....Pages 509-517
Tentative Identification of the Choline Transporter in Cholinergic Presynaptic Plasma Membrane Preparations from Torpedo Electric Organ....Pages 519-527
A Reconstituted Presynaptic Membrane Equipped with Protein Structures Which Permit the Calcium Dependent Release of Acetylcholine....Pages 529-538
Storage and Secretion of Acetylcholine and Dopamine by PC12 Cells....Pages 539-550
Effects of Exogenous Choline on Acetylcholine and Choline Contents and Release in Striatal Slices....Pages 551-564
Acetylcholine and Choline Contents of Rat Skeletal Muscle Determined by a Radioenzymatic Microassay: Effects of Drugs....Pages 565-574
Pre- and Postsynaptic Effects of Muscarinic Antagonists in the Isolated Guinea Pig Ileum....Pages 575-581
Presynaptic Modulation of Acetylcholine Release....Pages 583-592
Effect of Diisopropylfluorophosphate on Synaptic Transmission and Acetylcholine Sensitivity in Neuroblastoma-Myotube Co-Culture....Pages 593-598
Acetylcholine Release from Rat Diaphragm: A Search for Release Regulatory Mechanisms....Pages 599-606
Distribution of Presynaptic Receptors Modulating Acetylcholine Release....Pages 607-619
Muscarinic Receptor Activation Increases Efflux of Choline from Isolated Heart and Rat Cortex in Vivo. Interactions with Forskolin and IBMX....Pages 621-626
Long Term Potentiation of Cholinergic Transmission in the Sympathetic Ganglion....Pages 627-632
Control of the Release of [3H]-Acetylcholine from Rat Hippocampal Slices by Aminopyridines and Phencyclidine....Pages 633-641
A Comparison between Endogenous Acetylcholinerelease and [3H] Choline Outflow from Guinea-Pig Brain Slices....Pages 643-651
Relationship between Calcium Entry and ACh Release in K+-Stimulated Rat Brain Synaptosomes....Pages 653-660
Activation and Inhibition of the Nicotinic Receptor: Actions of Physostigmine, Pyridostigmine and Meproadifen....Pages 661-666
Molecular Relationship between Acetylcholinesterase and Acetylcholine Receptors....Pages 667-675
Acetylcholinesterase and the Maintenance of Neuromuscular Structure and Function....Pages 677-695
Striatal Dopamine-?-Aminobutyric Acid-Acetylcholine Interaction in Organophosphate-Induced Neurotoxicity....Pages 697-704
Polymorphism of Cholinesterase: Possible Insertion of the Various Molecular Forms in Cellular Structures....Pages 705-718
An Endogenous Neurotrophic Factor for the Maintenance of Acetylcholinesterase and Butyrylcholinesterase in the Preganglionically Denervated Superior Cervical Ganglion of the Cat....Pages 719-726
Pharmacokinetics of [14C]-Sarin and Its Changes by Obidoxime and Pralidoxime....Pages 727-732
Succinylcholine — A Method of Determination. Distribution and Elimination....Pages 733-741
Cholinergic Effects of HI-6 in Soman Poisoning....Pages 743-755
Acetylcholine Turnover in Mouse Brain: Influence of Cholinesterase Inhibitors....Pages 757-766
Central Versus Peripheral Antagonism of Cholinesterase Inhibitor Induced Lethality....Pages 767-779
Structural Gene Mutations Affecting Acetylcholinesterase and Choline Acetyltransferase Perturb Behavior and Development in a Simple Invertebrate....Pages 781-790
Biochemical Effects of Lecithin Administration....Pages 791-798
Factors Which Influence the Availability of Choline to Brain....Pages 799-816
The Utilization of Supplemental Choline by Brain....Pages 817-825
Effects of the Combined Treatment of Rats with Fluphenazine and Choline or Lecithin on the Striatal Cholinergic and Dopaminergic System....Pages 827-835
Mechanisms of Acetylcholine Synthesis: Coupling with Choline Transport....Pages 837-849
Target Tissue Influences on Cholinergic Development of Parasympathetic Motor Neurons....Pages 851-858
The Role of Glial Cells in Neuronal Acetylcholine Synthesis....Pages 859-867
The Efflux of Choline from Nerve Cells: Mediation by Ionic Gradients and Functional Exchange of Choline from Glia to Neurons....Pages 869-878
Choline Uptake in the Hippocampus: Inhibition of Septal-Hippocampal Cholinergic Neurons by Intraventricular Barbiturates....Pages 879-890
Studies on a cAMP-Dependent Protein Kinase Obtained from Nicotinic Receptor-Bearing Microsacs....Pages 891-906
Differential Effects of Carbachol and Oxotremorine on Muscarinic Receptors, Cyclic Amp Formation, and Phosphoinositide Turnover in Chick Heart Cells....Pages 907-913
Polyphosphoinositide and Phosphoprotein Responses to Muscarinic Receptor Activation in Bovine Adrenal Medulla....Pages 915-922
GABAA VS. GABAB Modulation of Septal-Hippocampal Interconnections....Pages 923-932
Septal Gabaergic Neurons: Localization and Possible Involvement in the Septal-Hippocampal Feedback Loop....Pages 933-937
Regulation of Drugs Affecting Striatal Cholinergic Activity by Corticostriatal Projections....Pages 939-946
Excitatory Amino Acid Influence on Striatal Cholinergic Transmission....Pages 947-951
Contribution of the Dorsal Noradrenergic Bundle to the Effect of Amphetamine on Acetylcholine Turnover....Pages 953-961
Substantia Innominata — Cortical Cholinergic Pathway: Regulatory Afferents....Pages 963-971
Enkephalinergic Modulation of Cholinergic Transmission in Parasympathetic Ganglia of the Cat Urinary Bladder....Pages 973-980
Vasoactive Intestinal Polypeptide-Muscarinic Cholinergic Interactions....Pages 981-990
Serotonin and a Role in the Modulation of Cholinergic Transmission in the Mammalian Prevertebral Ganglia....Pages 991-998
Cholinergic and Peptidergic Regulation of Ganglionic Tyrosine Hydroxylase Activity....Pages 999-1006
Regulation of Acetylcholine Release From Rodent Cerebrum by Presynaptic Receptors, Methionine Enkephalin and Substance P....Pages 1007-1017
Selective Facilitatory Effects of Vasoactive Intestinal Polypeptide on Muscarinic Mechanisms in Sympathetic and Parasympathetic Ganglia of the Cat....Pages 1019-1025
Interaction of Cyclic Amp with Muscarinic Autoinhibition of [3H]-Acetylcholine Secretion in Guinea-Pig Ileum Myenteric Plexus....Pages 1027-1037
Tendency for Repetitive Vagal Activity to Synchronize Cardiac Pacemaker Cells....Pages 1039-1045
Transient Inotropic and Dromotropic Responses to Brief Vagal Stimuli....Pages 1047-1056
Brain Acetylcholine in Hypertension and Behavior: Studies Using N-(4-Diethylamino-2-Butynyl)-Succinimide....Pages 1057-1066
Inhibition of Brain Acetylcholine Biosynthesis by Clonidine and Methyldopa: Relevance to Hypertensive Disease....Pages 1067-1069
Acetylcholine — Prostanoid Interaction in the Pulmonary Circulation....Pages 1071-1080
Long-Term Effects of AF64A on Learning and Memory Processes in the Rat....Pages 1081-1090
Biochemical and Behavioral Effects of Ethylcholine Mustard Aziridinium Ion....Pages 1091-1100
Histochemical and Biochemical Effects of the Injection of AF64A into The Nucleus Basalis of Meynert:Relevance to Animal Models of Senile Dementia of the Alzheimer Type....Pages 1101-1108
Neurotoxic Effects of Nitrogen Mustard Analogues of Choline....Pages 1109-1118
Synthesis, Storage and Release of Choline Analog Esters....Pages 1119-1126
A New Pharmacological Tool to Study Acetylcholine Storage in Nerve Terminals....Pages 1127-1136
Alkylating Derivatives of Oxotremorine Have Irreversible Actions on Muscarinic Receptors....Pages 1137-1143
Action of Phospholipase Neurotoxins on Torpedo Synaptosomes: Changes in Membrane Potential and Phosphoglyceride Composition....Pages 1145-1150
Studies of Two Novel Presynaptic Toxins....Pages 1151-1160
Back Matter....Pages 1161-1168
Conference on Dynamics of Cholinergic Function: Overview and Comments....Pages 1169-1176
....Pages 1177-1185