Ebook: Bioinformatics of Human Proteomics

“Bioinformatics of Human Proteomics” discusses the development of methods, techniques and applications in the field of protein bioinformatics, an important direction in bioinformatics. It collects contributions from expert researchers in order to provide a practical guide to this complex field of study. The book covers the protein interaction network, drug discovery and development, the relationship between translational medicine and bioinformatics, and advances in proteomic methods, while also demonstrating important bioinformatics tools and methods available today for protein analysis, interpretation and predication. It is intended for experts or senior researchers in the fields of clinical research-related biostatistics, bioinformatics, computational biology, medicine, statistics, system biology, molecular diagnostics, biomarkers, or drug discovery and development. Dr.Xiangdong Wang works as a distinguished professor of Respiratory Medicine at Fudan University, Shanghai, China. He serves as Director of Biomedical Research Center, Fudan University Zhongshan Hospital and adjunct professor of Clinical Bioinformatics at Lund University, Sweden. His main research is focused on the role of clinical bioinformatics in the development of disease-specific biomarkers and dynamic network biomarkers, the molecular mechanism of organ dysfunction and potential therapies.

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“Bioinformatics of Human Proteomics” discusses the development of methods, techniques and applications in the field of protein bioinformatics, an important direction in bioinformatics. It collects contributions from expert researchers in order to provide a practical guide to this complex field of study. The book covers the protein interaction network, drug discovery and development, the relationship between translational medicine and bioinformatics, and advances in proteomic methods, while also demonstrating important bioinformatics tools and methods available today for protein analysis, interpretation and predication. It is intended for experts or senior researchers in the fields of clinical research-related biostatistics, bioinformatics, computational biology, medicine, statistics, system biology, molecular diagnostics, biomarkers, or drug discovery and development.

Dr. Xiangdong Wang works as a distinguished professor of Respiratory Medicine at Fudan University, Shanghai, China. He serves as Director of Biomedical Research Center, Fudan University Zhongshan Hospital and adjunct professor of Clinical Bioinformatics at Lund University, Sweden. His main research is focused on the role of clinical bioinformatics in the development of disease-specific biomarkers and dynamic network biomarkers, the molecular mechanism of organ dysfunction and potential therapies.

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“Bioinformatics of Human Proteomics” discusses the development of methods, techniques and applications in the field of protein bioinformatics, an important direction in bioinformatics. It collects contributions from expert researchers in order to provide a practical guide to this complex field of study. The book covers the protein interaction network, drug discovery and development, the relationship between translational medicine and bioinformatics, and advances in proteomic methods, while also demonstrating important bioinformatics tools and methods available today for protein analysis, interpretation and predication. It is intended for experts or senior researchers in the fields of clinical research-related biostatistics, bioinformatics, computational biology, medicine, statistics, system biology, molecular diagnostics, biomarkers, or drug discovery and development.

Dr. Xiangdong Wang works as a distinguished professor of Respiratory Medicine at Fudan University, Shanghai, China. He serves as Director of Biomedical Research Center, Fudan University Zhongshan Hospital and adjunct professor of Clinical Bioinformatics at Lund University, Sweden. His main research is focused on the role of clinical bioinformatics in the development of disease-specific biomarkers and dynamic network biomarkers, the molecular mechanism of organ dysfunction and potential therapies.

Content:
Front Matter....Pages i-xiii
Clinical Bioinformatics in Human Proteomics Research....Pages 1-15
Proteomics Defines Protein Interaction Network of Signaling Pathways....Pages 17-38
Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation....Pages 39-74
Proteomics and Cancer Research....Pages 75-101
Toward Development of Novel Peptide-Based Cancer Therapeutics: Computational Design and Experimental Evaluation....Pages 103-126
Advances in Proteomic Methods....Pages 127-167
Clinical and Biomedical Mass Spectrometry: New Frontiers in Drug Developments and Diagnosis....Pages 169-185
Disease Biomarkers: Modelling MR Spectroscopy and Clinical Applications....Pages 187-205
Processing of Mass Spectrometry Data in Clinical Applications....Pages 207-233
Bioinformatics Approach for Finding Target Protein in Infectious Disease....Pages 235-255
Identification of Network Biomarkers for Cancer Diagnosis....Pages 257-275
Software Development for Quantitative Proteomics Using Stable Isotope Labeling....Pages 277-294
Clinical Translation of Protein Biomarkers Integrated with Bioinformatics....Pages 295-308
Proteomic Approaches for Urine Biomarker Discovery in Bladder Cancer....Pages 309-329
Antibody Microarrays and Multiplexing....Pages 331-359
Proteomics in Anaesthesia and Intensive Care Medicine....Pages 361-376
Erratum....Pages E1-E1
Back Matter....Pages 377-390

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“Bioinformatics of Human Proteomics” discusses the development of methods, techniques and applications in the field of protein bioinformatics, an important direction in bioinformatics. It collects contributions from expert researchers in order to provide a practical guide to this complex field of study. The book covers the protein interaction network, drug discovery and development, the relationship between translational medicine and bioinformatics, and advances in proteomic methods, while also demonstrating important bioinformatics tools and methods available today for protein analysis, interpretation and predication. It is intended for experts or senior researchers in the fields of clinical research-related biostatistics, bioinformatics, computational biology, medicine, statistics, system biology, molecular diagnostics, biomarkers, or drug discovery and development.

Dr. Xiangdong Wang works as a distinguished professor of Respiratory Medicine at Fudan University, Shanghai, China. He serves as Director of Biomedical Research Center, Fudan University Zhongshan Hospital and adjunct professor of Clinical Bioinformatics at Lund University, Sweden. His main research is focused on the role of clinical bioinformatics in the development of disease-specific biomarkers and dynamic network biomarkers, the molecular mechanism of organ dysfunction and potential therapies.

Content:
Front Matter....Pages i-xiii
Clinical Bioinformatics in Human Proteomics Research....Pages 1-15
Proteomics Defines Protein Interaction Network of Signaling Pathways....Pages 17-38
Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation....Pages 39-74
Proteomics and Cancer Research....Pages 75-101
Toward Development of Novel Peptide-Based Cancer Therapeutics: Computational Design and Experimental Evaluation....Pages 103-126
Advances in Proteomic Methods....Pages 127-167
Clinical and Biomedical Mass Spectrometry: New Frontiers in Drug Developments and Diagnosis....Pages 169-185
Disease Biomarkers: Modelling MR Spectroscopy and Clinical Applications....Pages 187-205
Processing of Mass Spectrometry Data in Clinical Applications....Pages 207-233
Bioinformatics Approach for Finding Target Protein in Infectious Disease....Pages 235-255
Identification of Network Biomarkers for Cancer Diagnosis....Pages 257-275
Software Development for Quantitative Proteomics Using Stable Isotope Labeling....Pages 277-294
Clinical Translation of Protein Biomarkers Integrated with Bioinformatics....Pages 295-308
Proteomic Approaches for Urine Biomarker Discovery in Bladder Cancer....Pages 309-329
Antibody Microarrays and Multiplexing....Pages 331-359
Proteomics in Anaesthesia and Intensive Care Medicine....Pages 361-376
Erratum....Pages E1-E1
Back Matter....Pages 377-390
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