Ebook: Mechanical and Chemical Signaling in Angiogenesis

This volume describes and discusses recent advances in angiogenesis research. The chapters are organized to address all biological length scales of angiogenesis: molecular, cellular and tissue in both in vivo and in vitro settings. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, chemistry and physics will be invited to contribute chapters which focus on the mechanical and chemical signals which affect and promote angiogenesis.

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This volume of Studies in Mechanobiology, Tissue Engineering and Biomaterials describes the most recent advances in angiogenesis research at all biological length scales: molecular, cellular and tissue, in both in vivo and in vitro settings. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, and chemistry have contributed chapters which focus on the mechanical and chemical signals which affect and promote blood vessel growth. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research.

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This volume of Studies in Mechanobiology, Tissue Engineering and Biomaterials describes the most recent advances in angiogenesis research at all biological length scales: molecular, cellular and tissue, in both in vivo and in vitro settings. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, and chemistry have contributed chapters which focus on the mechanical and chemical signals which affect and promote blood vessel growth. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research.

Content:
Front Matter....Pages i-vi
Mechanical and Chemical Regulation of Arterial and Venous Specification....Pages 1-17
Mechanosensory Pathways in Angiocrine Mediated Tissue Regeneration....Pages 19-45
Microfluidic Devices for Quantifying the Role of Soluble Gradients in Early Angiogenesis....Pages 47-70
Reactive Oxygen Species in Physiologic and Pathologic Angiogenesis....Pages 71-92
Microfluidic Devices for Angiogenesis....Pages 93-120
Vascular Cell Physiology Under Shear Flow: Role of Cell Mechanics and Mechanotransduction....Pages 121-141
Matrix Mechanics and Cell Contractility in Angiogenesis....Pages 143-160
Computational Modeling of Angiogenesis: Towards a Multi-Scale Understanding of Cell–Cell and Cell–Matrix Interactions....Pages 161-183
ECM Remodeling in Angiogenesis....Pages 185-209
Barrier Maintenance in Neovessels....Pages 211-226
Computational Models of Vascularization and Therapy in Tumor Growth....Pages 227-246
Biomaterials for Cell-Based Therapeutic Angiogenesis....Pages 247-259
Translation of Pro-Angiogenic and Anti-Angiogenic Therapies into Clinical Use....Pages 261-278
Back Matter....Pages 279-280

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This volume of Studies in Mechanobiology, Tissue Engineering and Biomaterials describes the most recent advances in angiogenesis research at all biological length scales: molecular, cellular and tissue, in both in vivo and in vitro settings. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, and chemistry have contributed chapters which focus on the mechanical and chemical signals which affect and promote blood vessel growth. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research.

Content:
Front Matter....Pages i-vi
Mechanical and Chemical Regulation of Arterial and Venous Specification....Pages 1-17
Mechanosensory Pathways in Angiocrine Mediated Tissue Regeneration....Pages 19-45
Microfluidic Devices for Quantifying the Role of Soluble Gradients in Early Angiogenesis....Pages 47-70
Reactive Oxygen Species in Physiologic and Pathologic Angiogenesis....Pages 71-92
Microfluidic Devices for Angiogenesis....Pages 93-120
Vascular Cell Physiology Under Shear Flow: Role of Cell Mechanics and Mechanotransduction....Pages 121-141
Matrix Mechanics and Cell Contractility in Angiogenesis....Pages 143-160
Computational Modeling of Angiogenesis: Towards a Multi-Scale Understanding of Cell–Cell and Cell–Matrix Interactions....Pages 161-183
ECM Remodeling in Angiogenesis....Pages 185-209
Barrier Maintenance in Neovessels....Pages 211-226
Computational Models of Vascularization and Therapy in Tumor Growth....Pages 227-246
Biomaterials for Cell-Based Therapeutic Angiogenesis....Pages 247-259
Translation of Pro-Angiogenic and Anti-Angiogenic Therapies into Clinical Use....Pages 261-278
Back Matter....Pages 279-280
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