Ebook: Design and Testing of Digital Microfluidic Biochips

This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.

This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.

• Describes practical design automation tools that address different design problems (e.g., synthesis, droplet routing, control-pin mapping, testing and diagnosis, and error recovery) in a unified manner;
• Applies test pattern generation and error-recovery techniques for digital microfluidics-based biochips;
• Uses real bioassays as evaluation examples, e.g., multiplexed in vitro human physiological fluids diagnostics, PCR, protein crystallization.

This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.

• Describes practical design automation tools that address different design problems (e.g., synthesis, droplet routing, control-pin mapping, testing and diagnosis, and error recovery) in a unified manner;
• Applies test pattern generation and error-recovery techniques for digital microfluidics-based biochips;
• Uses real bioassays as evaluation examples, e.g., multiplexed in vitro human physiological fluids diagnostics, PCR, protein crystallization.

Content:
Front Matter....Pages i-xi
Introduction....Pages 1-25
Cross-Contamination Avoidance for Droplet Routing....Pages 27-55
Synchronization of Concurrently-Implemented Fluidic Operations in Pin-Constrained Biochips....Pages 57-81
Optimization of Droplet Routing and Control-Pin Mapping to Electrodes....Pages 83-107
Built-In Self Test and Diagnosis....Pages 109-148
On-Line Testing and Test Generation....Pages 149-178
Integrated Control-Path Design and Error Recovery....Pages 179-199
Conclusions....Pages 201-202

This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.

• Describes practical design automation tools that address different design problems (e.g., synthesis, droplet routing, control-pin mapping, testing and diagnosis, and error recovery) in a unified manner;
• Applies test pattern generation and error-recovery techniques for digital microfluidics-based biochips;
• Uses real bioassays as evaluation examples, e.g., multiplexed in vitro human physiological fluids diagnostics, PCR, protein crystallization.

Content:
Front Matter....Pages i-xi
Introduction....Pages 1-25
Cross-Contamination Avoidance for Droplet Routing....Pages 27-55
Synchronization of Concurrently-Implemented Fluidic Operations in Pin-Constrained Biochips....Pages 57-81
Optimization of Droplet Routing and Control-Pin Mapping to Electrodes....Pages 83-107
Built-In Self Test and Diagnosis....Pages 109-148
On-Line Testing and Test Generation....Pages 149-178
Integrated Control-Path Design and Error Recovery....Pages 179-199
Conclusions....Pages 201-202
....