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The focus of this book is on mechanical aspects of skeletal fragility related to aging and osteoporosis. Topics include: Age-related changes in trabecular structure and strength; age-related changes in cortical material properties; age-related changes in whole-bone structure; predicting bone strength and fracture risk using image-based methods and finite element analysis; animal models of osteoporosis and aging; age-related changes in skeletal mechano responsiveness; exercise and physical interventions for osteoporosis.




The focus of this book is on mechanical aspects of skeletal fragility related to aging and osteoporosis. Topics include: Age-related changes in trabecular structure and strength; age-related changes in cortical material properties; age-related changes in whole-bone structure; predicting bone strength and fracture risk using image-based methods and finite element analysis; animal models of osteoporosis and aging; age-related changes in skeletal mechano responsiveness; exercise and physical interventions for osteoporosis.




The focus of this book is on mechanical aspects of skeletal fragility related to aging and osteoporosis. Topics include: Age-related changes in trabecular structure and strength; age-related changes in cortical material properties; age-related changes in whole-bone structure; predicting bone strength and fracture risk using image-based methods and finite element analysis; animal models of osteoporosis and aging; age-related changes in skeletal mechano responsiveness; exercise and physical interventions for osteoporosis.


Content:
Front Matter....Pages i-viii
Age-Related Changes in Whole-Bone Structure and Strength....Pages 1-30
Characterisation of Trabecular Bone Structure....Pages 31-51
Cortical Bone Mechanics and Composition: Effects of Age and Gender....Pages 53-85
Bone Microdamage and Its Contributions to Fracture....Pages 87-104
Changes in Cortical Bone Mineral and Microstructure with Aging and Osteoporosis....Pages 105-131
Factor of Risk for Fracture....Pages 133-150
Bisphosphonates and PTH for Preventing Fractures....Pages 151-176
Bone Cell Mechanoresponsiveness....Pages 177-190
The Effect of Aging on Skeletal Mechanoresponsiveness: Animal Studies....Pages 191-216
Skeletal Mechanoresponsiveness: Effects of Sex Hormones....Pages 217-234
Effects of Exercise and Physical Interventions on Bone: Clinical Studies....Pages 235-256
Back Matter....Pages 257-257


The focus of this book is on mechanical aspects of skeletal fragility related to aging and osteoporosis. Topics include: Age-related changes in trabecular structure and strength; age-related changes in cortical material properties; age-related changes in whole-bone structure; predicting bone strength and fracture risk using image-based methods and finite element analysis; animal models of osteoporosis and aging; age-related changes in skeletal mechano responsiveness; exercise and physical interventions for osteoporosis.


Content:
Front Matter....Pages i-viii
Age-Related Changes in Whole-Bone Structure and Strength....Pages 1-30
Characterisation of Trabecular Bone Structure....Pages 31-51
Cortical Bone Mechanics and Composition: Effects of Age and Gender....Pages 53-85
Bone Microdamage and Its Contributions to Fracture....Pages 87-104
Changes in Cortical Bone Mineral and Microstructure with Aging and Osteoporosis....Pages 105-131
Factor of Risk for Fracture....Pages 133-150
Bisphosphonates and PTH for Preventing Fractures....Pages 151-176
Bone Cell Mechanoresponsiveness....Pages 177-190
The Effect of Aging on Skeletal Mechanoresponsiveness: Animal Studies....Pages 191-216
Skeletal Mechanoresponsiveness: Effects of Sex Hormones....Pages 217-234
Effects of Exercise and Physical Interventions on Bone: Clinical Studies....Pages 235-256
Back Matter....Pages 257-257
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