Ebook: Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

First of all, I would like to share the great pleasure of the successful five-day symposium with every participant in the 5th Iketani Conference which was held in Kagoshima from April1S (Tuesday) to 22 (Saturday), 1995. Outstanding speakers enthusiastically presented their up-to-the-minute results. Relatively little time was allotted for each presentation to ensure asdnuch time· as possible for intensive discussions on the particular topics that had just been p~esented: I was delighted to see that the lectures were of high quality, and the discu,ssionswere lively, exciting, and productive in a congenial atmosphere. We also had 92 papers in the poster ·session, in which young (and relatively young) scientists made every effort to present the novel results of their research in advanced biomaterials and drug delivery systems (DDS). I believe some of the research is most promising and will become noteworthy in the twenty-first century. It was a privilege for me to deliver a lecture at the special session of the symposium. In my introductory remarks, I pointed out five key terms in multifaceted biomaterials research: materials design, concept or methodology, devices, properties demanded, and fundamentals. I am confident that innovative progress in device manufacturing for end-use, e.g., artificial organs, vascular grafts, and DDS, can be brought about only through properly designed advanced materials that exhibit the desired functionality at the interface with any living body.

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Content:
Front Matter....Pages II-XXIV
Front Matter....Pages 1-1
Controlled Release Systems Using Swellable Random and Block Copolymers and Terpolymers....Pages 3-7
Polymer Gel-A New Type of Soft Energy Transducer....Pages 8-12
Communicating with the Building Blocks of Life Using Advanced Macromolecular Transducers....Pages 13-17
Water-Soluble Nucleic Acid Analogs — Preparation and Properties....Pages 18-22
Intelligent Materials....Pages 23-27
Functional Synthetic and Semisynthetic Polymers in Biomedical Applications....Pages 28-31
Bioconjugates from Synthetic Polymers -How they can be married?-....Pages 32-37
Plasma Modification of Polymeric Surfaces for Biomedical Applications....Pages 38-42
New Polymeric Materials Design for Biomedical Applications....Pages 43-47
Front Matter....Pages 49-49
New Oral Drug Delivery System....Pages 51-56
Penetration of Polymeric Drug Carriers into K562 Cells....Pages 57-61
Novel Bioadhesive, pH- and Temperature-Sensitive Graft Copolymers for Prolonged Mucosal Drug Delivery....Pages 62-66
Enhanced Intestinal Absorption of Peptides by Complexation of the Partially Denatured Peptide....Pages 67-70
Controlled Drug Delivery Formulation with Safe Polymers....Pages 71-75
Supramolecular Assemblies for Improved Drug Delivery System....Pages 76-80
Biodegradable Polyphosphazenes for Biomedical Applications....Pages 81-85
Receptor-Mediated Cell Specific Delivery of Drugs to the Liver and Kidney....Pages 86-90
Biorecognizable Biomedical Polymers....Pages 91-95
Nanoscopic Vehicles with Core-Shell Structure for Drug Targeting....Pages 96-100
Third Phase in Polymer Drug Development: — Smancs as a Prototype Model Drug for Cancer Treatment —....Pages 101-105
Front Matter....Pages 49-49
Development of a Tetracycline Delivery System for the Treatment of Periodontal Disease Using a Semisolid Poly(Ortho Ester)....Pages 106-110
Mechanistic Aspects of Transdermal Drug Transport....Pages 111-115
Transbuccal Delivery of Polar Compounds....Pages 116-120
Receptor-Mediated Targeting of Peptides and Proteins....Pages 121-125
Temperature Sensitive Polymers for Delivery of Macromolecular Drugs....Pages 126-133
Front Matter....Pages 135-135
Novel Biomaterials as Artificial Cornea via Plasma Induced Grafted Polymerization....Pages 137-141
Ultrathin Polymeric Films as Biomedical Interfaces of Controlled Chemical Architecture....Pages 142-146
Randomness and Biospecificity : Random Copolymers are Endowed with Biospecific Properties....Pages 147-152
Strategy and Bionic Design of Vital Functioning Vascular Wall Reconstruction....Pages 153-157
Surface Modification of Biomaterials by Topographic and Chemical Patterning....Pages 158-162
Polymer-Supported Tissue Engineering....Pages 163-167
New Frontier of Biomimetic Glycotechnology for Cellular and Tissue Engineering....Pages 168-172
Control of Healing with Photopolymerizable Biodegradable Hydrogels....Pages 173-178
A Novel Biomateral: Aramid-Silicone Resin....Pages 179-182
Gradient Surfaces as Tools to Study Biocompatibility....Pages 183-187
Preparation of Self-Assembled Biomimetic Membranes and Their Functions....Pages 188-192
Synthesis and Cell-Adhesion Properties of Polyurethanes Containing Covalently Grafted RGD-Peptides....Pages 193-197
Front Matter....Pages 198-202
One Pot Synthesis of Poly(Ethylene Oxide) with a Cyano Group at one End and a Hydroxyl Group at the Other End....Pages 203-203
Creation of New Si-containing Block Copolymer Membrane with Both High Gas Permeability and Blood compatibility....Pages 205-206
Front Matter....Pages 207-208
Surface Modification of Poly(Lactic Acid) with Bioactive Peptides....Pages 203-203
Adsorption of Biomolecules onto Multiblock Copolymer Consisting of Aromatic Polyamide and Poly(Dimethylsiloxane)....Pages 209-210
Hemocompatible Cellulose Dialysis Membrane Modified with Phospholipid Polymer....Pages 211-212
Artificial Glycoconjugate Polymers: Cell-Specific Biomedical Materials Using Carbohydrates as Recognition Signals....Pages 213-214
Preparation of Acrylamide Coated PVC Tube by APG Treatment and Its Characterization....Pages 215-216
Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer....Pages 217-218
Histological and Morphological Comparison of Explanted Small Diameter PU and ePTFE Vascular Prostheses: A Preliminary Study....Pages 219-220
Poly (Acrylamides) Containing Sugar Residues :Synthesis, Characterization and Cell Compatibility Studies....Pages 221-222
Molecular Design of Artificial Lectin; Recognition and Killer Cell Induction of Lymphocytes by a Novel Water Soluble Polymer Having Phenylboronic Acid Moiety....Pages 223-224
Selective Adhesion and Spontaneous Fusion of Platelets on Polyion Complex Composed of Phospholipid Polymers....Pages 225-226
Thermo-Responsive Polymer Surfaces for Cell Culture: Analysis of the Surfaces and Control of the Cell Attachment / Detachment....Pages 227-228
Rgds-Carrying Latex Particles for Cell Activation and Integrin Separation....Pages 229-230
Estimation of the Secondary Structure of Fibronectin Adsorbed to Polystyrene and Deprotected Poly(?-N-Benzyloxycarbonyl-L-Lysine) by FTIR ATR Spectroscopy....Pages 231-232
Hybrid Biomaterials Comprising Double-Helical DNA. Covalent Coupling Between ? Phage DNA and Poly(N-Isopropylacrylamide)....Pages 233-234
Preparation of Glucose-Sensitive Hydrogels by Entrapment or Copolymerization of Concanavalin a in a Glucosyloxyethyl Methacrylate Hydrogel....Pages 235-236
Complexation of Neocarzinostatin Chromophore with a Hydrophobized Polysaccharide as an Apoprotein Model....Pages 237-238
Hydrolytic Degradation of Poly(L-Lactide-co-?-Caprolactone)S....Pages 239-240
Selective Adsorption of Plasma Protein Onto Phase-Separated Domain of Immobilized Organosilane Monolayer Surfaces....Pages 241-242
The Possibility of the Constitution of an Artificial Thymus by Utilizing Keratinocytes....Pages 243-244
Improved Nonthrombogenicity of Heparin Immobilized and Sulfonated Polyurethane: In Vitro Evaluation Using Epifluorescent Video Microscopy....Pages 245-246
Front Matter....Pages 247-248
Evaluation of a Newly Developed Biological Patch....Pages 203-203
Application of Hema-St Block Copolymer Coated Small Caliber Vascular Graft for Veins....Pages 249-250
Transfer and Surface Fixation of Gels by an Excimer Laser Ablation....Pages 251-252
PVA Hydrogel as an Artificial Vitreous Body....Pages 253-254
Analysis of Plasma Membrane Glycocalyx and/or of Quantitative Computerized Cytological Image of Platelets Adhered to Hema-St ABA Type Block Copolymer Surfaces with Good Antithrombogenicity....Pages 255-256
Immobilization of Human Thrombomodulin Onto Biomaterials: Evaluation of Antithrombogenicity Using Small Dialyzer....Pages 257-258
Surface Characterization of Hema-Styrene Block Copolymer Using Transmission Electron Microscopy....Pages 259-260
Induction of Endothelial Cell Differentiation on Copolymer Surfaces Having Phenylboronic Acid Groups....Pages 261-262
Immobilization of Biosignal Proteins to Control Cellular Functions....Pages 263-264
Temperature-Modulated Surface Hydrophilic/Hydrophobic Alterations for Novel Recovery of Cultured Cells....Pages 265-266
Cell Cultures on Plasma-Modified Nylon Meshes and Collagen/Nylon Composite Biomatrix....Pages 267-268
Direct Extraction of Taste Receptor Proteins by Liposome from Intact Epithelium of Bullfrog Tongue....Pages 269-270
The Influence of Serum on The Spreading of Tumor Cells on Synthetic Glycolipid Films....Pages 271-272
Transfer of Membrane Proteins from Human Erythrocytes to Liposomes....Pages 273-274
Reconstitution of Bovine Placental Insulin Receptor on Artificial Vesicles by Using Direct Protein Transfer Techniques....Pages 275-276
Protein Reconstitution from Cell Membrane to Monolayer Using Direct Transfer Technique....Pages 277-278
Glucose Responsive Inter-Polymer Complex Gel Based on the Complexation Between Boronic Acid and Polyols —Mechanism of Gelation and Glucose Exchange—....Pages 279-280
Synthesis of Ionic Polyurethane Elastomers as Chemomechanical Materials....Pages 281-282
A Synthetic Polyanion Polymer as a Growth Promoter for L929 Mouse Fibroblast....Pages 283-284
Adhesion of Fibroblast onto Poly(?-Benzyl L-Glutamate)/Poly(Ethylene Oxide) Diblock Copolymer Langmuir-Blodgett Films....Pages 285-286
Front Matter....Pages 287-288
New Bioactive Macromolecular Glycolipids from Bacterial Cell Surface....Pages 203-203
Stabilization of Enzyme by Polymer with Pendant Monosaccharide....Pages 289-290
Molecular Architecture of Temperature-Responsive Bioconjugates....Pages 291-292
Stabilization of L-Asparaginase by Chemical Modification with Poly(Ethylene Glycol) Derivatives....Pages 293-294
New Polymeric Hydrogels for the Removal of Uraemic Toxins....Pages 295-296
Estimation of Biocompatibility of Polymeric Materials Using RT-PCR Method....Pages 297-298
Temperature Responsive Swelling-Deswelling Kinetics of Poly(N-Isopropylacrylamide) Grafted Hydrogels....Pages 299-300
Temperature-Sensitive Changes in Surface Properties of a Poly(N-Isopropylacrylamide) Hydrogel Layer....Pages 301-302
Efect of Anion-Exchange Capacity and Porosity of Polyethyleneimine-Immobilized Cellulose Fibers on Selective Removal of Endotoxin....Pages 303-304
Cellular communication with conducting electroactive polymers....Pages 305-306
Front Matter....Pages 307-308
Stimuli-Sensitive Release of Lysozyme from Hydrogel Containing Phosphate Groups....Pages 309-310
Slow Release of Heparin from a Hydrogel Made from Polyamine Chains Grafted to a Temperature-Sensitive Polymer Backbone....Pages 311-311
Formation of core-shell type nano-associates through electrostatic interaction between peptide and block copolymer with poly(ethylene glycol) segment....Pages 313-314
PEG-Poly(lysine) block copolymer as a novel type of synthetic gene vector with supramolecular structure....Pages 315-316
Development of Polymeric Micelles for Drug Delivery of Indomethacin....Pages 317-318
Synthesis of heterobifunctional poly(ethylene glycol) with a reducing monosaccharide residue at one end for drug delivery....Pages 319-320
Functional Polymeric Micelles: Synthesis and Characterization....Pages 321-322
Micelle Forming Polymeric Anticancer Drug Containing Chemically Bound and Physically Incorporated Adriamycin....Pages 323-324
Pharmaceutical Aspects of Block Copolymer Micelles....Pages 325-326
Front Matter....Pages 327-328
Nanosize Hydrogel Formed by Self-Assembly of Hydrophobized Polysaccharides....Pages 329-330
Novel Design of Supramolecular-Structured Biodegradable Polymer for Drug Delivery....Pages 311-311
Interaction of Poly(ethylene Oxide)-Bearing Lipid Reconstituted Liposomes With Murine B16 Melanoma Cells....Pages 331-332
Physical Stabilization of Insulin through Chemical Modification: Site-Specific Glycosylation or Pegylation....Pages 333-334
Therapeutic Effects of the Soybean Trypsin Inhibitor and Its Gelatin Conjugate on the Pseudomonal Elastase Induced Shock in Guinea Pig....Pages 335-336
The Pulsatile Release System of Macromolecular Drugs from Alginate Gel Beads....Pages 337-338
Albumin Release from Bioerodible Hydrogels Based on Semi-Interpenetrating Polymer Networks Composed of Poly(?-Caprolactone) and Poly (Ethylene Glycol) Macromer....Pages 339-340
A Novel Drug Delivery System of Hepatocyte Growth Factor (HGF): Utilization of Heparin-HGF Complex....Pages 341-342
New Polymeric Hydrogel Formulations for the Controlled Release of Proteic Drugs. DSC Investigation of Water Structure....Pages 343-344
Degradation Mechanism of AZO-Containing Polyurethanes by the Action of Intestinal Flora....Pages 345-346
Novel Immunoliposomes Modified with Amphipathic Polyethyleneglycols Conjugated at their Distal Terminals to Monoclonal Antibodies....Pages 347-348
Photo-Induced Drug Release from Liposome Using Photochromic Lipid Having Spiropyran Group....Pages 349-350
New Structurally Modified Cyclodextrins for Controlled Release of Antihypertensive Drugs....Pages 351-352
Development of Delivery Systems for Antisense Oligonucleotides....Pages 353-354
Transfection to Smooth Muscle Cells Using Terplex of LDL, DNA, and Hydrophobized Cationic Polymers....Pages 355-356
Preparation of Ammonio-Terminated Polyoxyethylene/Polydimethylsiloxane Block Copolymer and Application to Transdermal Penetration Enhancer....Pages 357-358
Theoretical Design of Skin Penetration Enhancement Via Prodrug-Enhancer Combination Based on a Diffusion Model....Pages 359-360
Preparation of Biodegradable Microspheres Containing Water-Soluble Drug, ?-Lactam Antibiotic....Pages 361-362
Effect of Micropore Structure on Drug Release Form Self-Setting Calcium Phosphate Cement Containing Anti-Cancer Agent....Pages 363-364
Amine Effect on Controlled Release of Insulin from Phenylboronic Acid Gel in Physiological pH....Pages 365-366
Back Matter....Pages 367-368
Drug Releasing Mechanism from Redox Active Micelles....Pages 369-370
....Pages 373-381