Ebook: Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion

In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe compre­ hensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor­ mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre­ tion may be the crucial step in the pathogenesis of noninsulin-depen­ dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha­ nisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.

---

---

Content:
Front Matter....Pages i-xiii
Front Matter....Pages N1-N1
Molecular Targets of the Autoimmunity of Type I Diabetes....Pages 1-33
Murine Transgenic Models of IDDM....Pages 35-47
Pancreatic Islet Transplantation....Pages 49-67
Pathogenesis of Autoimmune Diabetes....Pages 69-90
Front Matter....Pages N2-N2
Insulin Gene Structure and Regulation....Pages 91-117
Molecular Engineering of Glucose-Regulated Insulin Secretion....Pages 119-154
Glucokinase Gene Expression and Regulation....Pages 155-174
Fundamentals of Fuel Sensing and Intermediary Metabolism in Pancreatic A-and B-Cells....Pages 175-193
Glucose Toxicity and the Insulin Gene....Pages 195-212
Proinsulin-Processing Endopeptidases....Pages 213-248
GTP and Its Binding Proteins in the Regulation of Insulin Exocytosis....Pages 249-283
?-Cell Receptors....Pages 285-301
Molecular Biology of the Ion Channels in the Pancreatic ?-Cell....Pages 303-332
Molecular Biology of Gap Junction Proteins....Pages 333-356
The GIuco-Incretin Hormone Glucagon-Like Peptide-1 and Its ?-Cell Receptor....Pages 357-379
Islet Amyloid Polypeptide (IAPP) and Insulin Secretion....Pages 381-398
Back Matter....Pages 399-404

---

Content:
Front Matter....Pages i-xiii
Front Matter....Pages N1-N1
Molecular Targets of the Autoimmunity of Type I Diabetes....Pages 1-33
Murine Transgenic Models of IDDM....Pages 35-47
Pancreatic Islet Transplantation....Pages 49-67
Pathogenesis of Autoimmune Diabetes....Pages 69-90
Front Matter....Pages N2-N2
Insulin Gene Structure and Regulation....Pages 91-117
Molecular Engineering of Glucose-Regulated Insulin Secretion....Pages 119-154
Glucokinase Gene Expression and Regulation....Pages 155-174
Fundamentals of Fuel Sensing and Intermediary Metabolism in Pancreatic A-and B-Cells....Pages 175-193
Glucose Toxicity and the Insulin Gene....Pages 195-212
Proinsulin-Processing Endopeptidases....Pages 213-248
GTP and Its Binding Proteins in the Regulation of Insulin Exocytosis....Pages 249-283
?-Cell Receptors....Pages 285-301
Molecular Biology of the Ion Channels in the Pancreatic ?-Cell....Pages 303-332
Molecular Biology of Gap Junction Proteins....Pages 333-356
The GIuco-Incretin Hormone Glucagon-Like Peptide-1 and Its ?-Cell Receptor....Pages 357-379
Islet Amyloid Polypeptide (IAPP) and Insulin Secretion....Pages 381-398
Back Matter....Pages 399-404
....