Ebook: Transgenic Animals as Model Systems for Human Diseases

Some of the current concepts used in transgenic research, an increasingly important tool to study the regulation and function of genes, are illustrated in this book. With these techniques, animal models can be used to study human diseases; this opens up new possibilities in both applied and basic research. Specifically, the ability to introduce genes into the germline of mice and the successful expression of the inserted gene within an organism provide new insights and opportunities for biomedical research. The discussion here shows how a detailed analysis of the underlying molecular mechanisms will provide new insights into the genetic origin of certain diseases and will lead to a better understanding of normal and abnormal physiological processes.

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Content:
Front Matter....Pages I-XII
The Human Renin-Angiotensin System in Transgenic Rats — New Tools for Antihypertensive Therapy....Pages 1-23
Probing the Genetics of Atherosclerosis in Transgenic Mice....Pages 25-37
The PrP-less Mouse: A Tool for Prion Research....Pages 39-56
The Carboxyterminal Fragment of the Alzheimer Amyloid Protein Precursor Causes Neurodegeneration In Vivo....Pages 57-72
Transgenic Models of Chronic Arthritis and of Systemic Tumour Necrosis Factor-Mediated Disease in Mice Expressing Human Tumour Necrosis Factor....Pages 73-90
Mammary Neoplasia in Mouse Mammary Tumor Virus-Transforming Growth Factor ? Transgenic Mice....Pages 91-108
Exploring the Pathogenic Potential of c-fos, Polyoma Middle T and Human Foamy Virus in Transgenic Mice....Pages 109-128
Transgenic Animals as Bioreactors for Therapeutic and Nutritional Proteins....Pages 129-141
Targeted Inactivation of the Muscle Regulatory Genes Myf-5 and MyoD: Effect on Muscle and Skeletal Development....Pages 143-151

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Content:
Front Matter....Pages I-XII
The Human Renin-Angiotensin System in Transgenic Rats — New Tools for Antihypertensive Therapy....Pages 1-23
Probing the Genetics of Atherosclerosis in Transgenic Mice....Pages 25-37
The PrP-less Mouse: A Tool for Prion Research....Pages 39-56
The Carboxyterminal Fragment of the Alzheimer Amyloid Protein Precursor Causes Neurodegeneration In Vivo....Pages 57-72
Transgenic Models of Chronic Arthritis and of Systemic Tumour Necrosis Factor-Mediated Disease in Mice Expressing Human Tumour Necrosis Factor....Pages 73-90
Mammary Neoplasia in Mouse Mammary Tumor Virus-Transforming Growth Factor ? Transgenic Mice....Pages 91-108
Exploring the Pathogenic Potential of c-fos, Polyoma Middle T and Human Foamy Virus in Transgenic Mice....Pages 109-128
Transgenic Animals as Bioreactors for Therapeutic and Nutritional Proteins....Pages 129-141
Targeted Inactivation of the Muscle Regulatory Genes Myf-5 and MyoD: Effect on Muscle and Skeletal Development....Pages 143-151
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