Ebook: Biomedical Modeling and Simulation on a PC: A Workbench for Physiology and Biomedical Engineering

I have long had an interest in the life sciences, but have had few opportunities to indulge that interest in my professional activities. It has only been through simulation that those opportunities have arisen. Some of my most enjoyable classes were those I taught to students in the life sciences, where I attempted to show them the value of simulation to their discipline. That there is such a value cannot be questioned. Whether you are interested in population ecology, phar­ macokinetics, the cardiovascular system, or cell interaction, simulation can play a vital role in explaining the underlying processes and in enhancing our understanding of these processes. This book comprises an excellent collection of contributions, and clearly demonstrates the value of simulation in the particular areas of physiology and bioengineering. My main frustration when teaching these classes to people with little or no computer background was the lack of suitable simulation software. This di­ rectly inspired my own attempts at producing software usable by the computer novice. It is especially nice that software is available that enables readers to experience the examples in this book for themselves. I would like to congratulate and thank the editors, Rogier P. van Wijk van Brievingh and Dietmar P. P. Moller, for all of their excellent efforts. They should be proud of their achievement. This is the sixth volume in the Advances in Simulation series, and other volumes are in preparation.

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This book and the available software are intended for use by teachers in Physiology and Biomedical Engineering. It offers them the opportunity to enrich their courses with demonstrations and exercises for students using a personal computer. Chapters and simulation programs have been contributed by outstanding experts in the field; the material is based on validated models throughout. An educational context is given stimulating the teacher to induce investigative learning with his students. For theory, reference is made to standard textbooks; the aim of instruction, the possibilities and limitations of the model and an outlook for the future are given for each subject. The models are included either as files to be used with the simulation language BIOPSI or as stand-alone programs. An extensive menu-system is supplied, featuring: Context-sensitive "Help" for each program; facilities for automatic curve-presentation; student databases with extensive reporting facilities; WYSIWYG text editor for special as well as for general use; installation for IBM XT/AT personal computers or true compatibles with CGA/EGA/VGA or Hercules graphics adapter. 2MB of hard disk space and DOS version 2.0 or higher are required.

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This book and the available software are intended for use by teachers in Physiology and Biomedical Engineering. It offers them the opportunity to enrich their courses with demonstrations and exercises for students using a personal computer. Chapters and simulation programs have been contributed by outstanding experts in the field; the material is based on validated models throughout. An educational context is given stimulating the teacher to induce investigative learning with his students. For theory, reference is made to standard textbooks; the aim of instruction, the possibilities and limitations of the model and an outlook for the future are given for each subject. The models are included either as files to be used with the simulation language BIOPSI or as stand-alone programs. An extensive menu-system is supplied, featuring: Context-sensitive "Help" for each program; facilities for automatic curve-presentation; student databases with extensive reporting facilities; WYSIWYG text editor for special as well as for general use; installation for IBM XT/AT personal computers or true compatibles with CGA/EGA/VGA or Hercules graphics adapter. 2MB of hard disk space and DOS version 2.0 or higher are required.
Content:
Front Matter....Pages i-xvi
State of the Art and Future Aspects of Modeling and Simulation in Physiology and Biomedical Engineering....Pages 1-34
Computer Simulation as an Educational Tool....Pages 35-52
Artificial Intelligence and Simulation: An Introductory Review....Pages 53-73
Simulation: A General Design Tool....Pages 74-83
Experience in Teaching with the Help of Models....Pages 84-88
How to Use This Book....Pages 89-93
The Excitable Membrane: The Hodgkin-Huxley Model....Pages 94-129
The Specific Conduction System of the Heart....Pages 130-134
Electrodes for Bioelectric Signals....Pages 135-155
The Heart as a Pump: The Program “CARDIO”....Pages 156-172
A Model of the Baroreflex-Controlled Circulation with Emphasis on the Baromodulation Hypothesis....Pages 173-187
Pumping and Wall Mechanics of the Left Ventricle....Pages 188-194
Heart Rate Regulation During Physical Load....Pages 195-210
Catheter-Manometer Systems....Pages 211-225
Regulation of Respiration....Pages 226-237
A Model for Capnograms from the Bain Circuit....Pages 238-248
Renal Function and Blood Pressure Stabilization....Pages 249-264
Urodynamics of the Lower Urinary Tract....Pages 265-285
Fluid Volumes: The Program “FLUIDS”....Pages 286-307
Pharmacokinetics....Pages 308-321
Optimal Experiment Design in Pharmacokinetics....Pages 322-333
The Cerebrospinal Fluid Circulation Model....Pages 334-343
Blood Glucose Regulation by the Pancreas and the Kidney....Pages 344-386
Regulation of Gastric Acidity....Pages 387-409
Thermoregulation....Pages 410-421
Muscle Control....Pages 422-438
How to Use the Student Programs....Pages 439-443
How to Use the Teacher’s Facilities....Pages 444-457
The Student Database....Pages 458-470
Interactive Simulation Program BIOPSI....Pages 471-502
Back Matter....Pages 503-517

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This book and the available software are intended for use by teachers in Physiology and Biomedical Engineering. It offers them the opportunity to enrich their courses with demonstrations and exercises for students using a personal computer. Chapters and simulation programs have been contributed by outstanding experts in the field; the material is based on validated models throughout. An educational context is given stimulating the teacher to induce investigative learning with his students. For theory, reference is made to standard textbooks; the aim of instruction, the possibilities and limitations of the model and an outlook for the future are given for each subject. The models are included either as files to be used with the simulation language BIOPSI or as stand-alone programs. An extensive menu-system is supplied, featuring: Context-sensitive "Help" for each program; facilities for automatic curve-presentation; student databases with extensive reporting facilities; WYSIWYG text editor for special as well as for general use; installation for IBM XT/AT personal computers or true compatibles with CGA/EGA/VGA or Hercules graphics adapter. 2MB of hard disk space and DOS version 2.0 or higher are required.
Content:
Front Matter....Pages i-xvi
State of the Art and Future Aspects of Modeling and Simulation in Physiology and Biomedical Engineering....Pages 1-34
Computer Simulation as an Educational Tool....Pages 35-52
Artificial Intelligence and Simulation: An Introductory Review....Pages 53-73
Simulation: A General Design Tool....Pages 74-83
Experience in Teaching with the Help of Models....Pages 84-88
How to Use This Book....Pages 89-93
The Excitable Membrane: The Hodgkin-Huxley Model....Pages 94-129
The Specific Conduction System of the Heart....Pages 130-134
Electrodes for Bioelectric Signals....Pages 135-155
The Heart as a Pump: The Program “CARDIO”....Pages 156-172
A Model of the Baroreflex-Controlled Circulation with Emphasis on the Baromodulation Hypothesis....Pages 173-187
Pumping and Wall Mechanics of the Left Ventricle....Pages 188-194
Heart Rate Regulation During Physical Load....Pages 195-210
Catheter-Manometer Systems....Pages 211-225
Regulation of Respiration....Pages 226-237
A Model for Capnograms from the Bain Circuit....Pages 238-248
Renal Function and Blood Pressure Stabilization....Pages 249-264
Urodynamics of the Lower Urinary Tract....Pages 265-285
Fluid Volumes: The Program “FLUIDS”....Pages 286-307
Pharmacokinetics....Pages 308-321
Optimal Experiment Design in Pharmacokinetics....Pages 322-333
The Cerebrospinal Fluid Circulation Model....Pages 334-343
Blood Glucose Regulation by the Pancreas and the Kidney....Pages 344-386
Regulation of Gastric Acidity....Pages 387-409
Thermoregulation....Pages 410-421
Muscle Control....Pages 422-438
How to Use the Student Programs....Pages 439-443
How to Use the Teacher’s Facilities....Pages 444-457
The Student Database....Pages 458-470
Interactive Simulation Program BIOPSI....Pages 471-502
Back Matter....Pages 503-517
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