Ebook: Monoclonal Antibodies and Functional Cell Lines: Progress and Applications
- Tags: Antibodies, Biomedical Engineering
- Year: 1984
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
This volume serves as a follow-up to our previous book, MonoclonalAntibodies Hybridomas: A New Dimension in Biological Analyses. We continue the theme of monoclonal antibodies and their applications, attempting to cover some of the areas not covered in the previous volume. We again include an appendix de scribing methods useful to those who ar-e beginning to apply these techniques in their own laboratories. This volume will be followed by another concentrating on the combination of monoclonal antibody techniques with molecular genetic techniques to study structure/function relationships at the level of both the gene and gene product. Roger H. Kennett Kathleen B. Bechtol Philadelphia, Pennsylvania Thomas J. McKearn Princeton, New Jersey IX Acknowledgments Roger Kennett acknowledges the patience and support of his wife, Carol, and his family, friends, and colleagues during the work on this volume, and again thanks, above all, the Lord, Jesus Christ. Kathleen Bechtol wishes to thank colleagues and friends for their support and understanding during the months of preparation of this volume. Tom McKearn acknowledges and thanks his wife, Pat, and his family for their support and encouragement. Xl Contents PART I INTRODUCTION 1 Introduction: Reflections on Nine Years of Monoclonal Antibodies from Hybridomas 3 ROGER H. KENNETT, KATHLEEN B. BECHTOL, AND THOMAS J. McKEARN 1. Biotechnology'S "Coming of Age". . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 II. Monoclonal Antibodies-An Overview of Applications. . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 III. Commercialization of Monoclonal Antibody Technology.. . . .. ... . .... .... .. . ... . . 10 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 . . . . . . . . . . . . . . . . . . . . .
Content:
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Introduction....Pages 3-14
Front Matter....Pages 15-15
Monoclonal Antibodies Directed against the Nicotinic Acetylcholine Receptor....Pages 17-31
Monoclonal Antibodies to Enzymes....Pages 33-65
Monoclonal Antibodies Directed to Cell-Surface Carbohydrates....Pages 67-100
Front Matter....Pages 101-101
Adhesion-Related Integral Membrane Glycoproteins Identified by Monoclonal Antibodies....Pages 103-118
Monoclonal Antibodies to Cytoskeletal Proteins....Pages 119-151
Molecular Bases of Neuronal Individuality....Pages 153-189
Front Matter....Pages 191-191
Monoclonal Antibodies to Human Lymphocytes....Pages 193-214
Monoclonal Antibodies to Human Neuroblastoma Cells and Other Solid Tumors....Pages 215-237
Monoclonal Antibodies and Immunoparasitology....Pages 239-272
Front Matter....Pages 273-273
Production of Human Monoclonal Antibodies....Pages 275-309
Monoclonal Antibodies and Molecular Genetics....Pages 311-340
Functional Murine T-Cell Clones....Pages 341-363
Back Matter....Pages 365-426
Content:
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Introduction....Pages 3-14
Front Matter....Pages 15-15
Monoclonal Antibodies Directed against the Nicotinic Acetylcholine Receptor....Pages 17-31
Monoclonal Antibodies to Enzymes....Pages 33-65
Monoclonal Antibodies Directed to Cell-Surface Carbohydrates....Pages 67-100
Front Matter....Pages 101-101
Adhesion-Related Integral Membrane Glycoproteins Identified by Monoclonal Antibodies....Pages 103-118
Monoclonal Antibodies to Cytoskeletal Proteins....Pages 119-151
Molecular Bases of Neuronal Individuality....Pages 153-189
Front Matter....Pages 191-191
Monoclonal Antibodies to Human Lymphocytes....Pages 193-214
Monoclonal Antibodies to Human Neuroblastoma Cells and Other Solid Tumors....Pages 215-237
Monoclonal Antibodies and Immunoparasitology....Pages 239-272
Front Matter....Pages 273-273
Production of Human Monoclonal Antibodies....Pages 275-309
Monoclonal Antibodies and Molecular Genetics....Pages 311-340
Functional Murine T-Cell Clones....Pages 341-363
Back Matter....Pages 365-426
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