Ebook: Basic Biology of New Developments in Biotechnology

Allen I. Laskin Biosciences Research Exxon Research and Engineering Company Linden, New Jersey I was contacted in the Fall of 1981 by Professors Martin Dworkin and Palmer Rogers, of the University of Minnesota and asked to participate in the orgnization of the 1983 conference in the series, "Interface Between Biology and Medicine". They and the other members of the advisory committee had the vision to realize that this was a time to depart somewhat from the traditional theme, since one of the major areas of interest in the biological and related sciences these days is that of biotechnology in a broader sense than its impact on medicine alone. In designing the format of the Conference, we considered another factor. There has been a plethora of conferences, symposia, and meetings on biotechnology over the past few years, and the faces and topics have become rather familiar. There has been a strong emphasis on the development of the technology and the "biotechnology industry"; less attention has been paid to the science behind it. One might get the impression from some of these meetings and from the popular press that biotechnology has just recently sprung up, apparently full blown; the very fundamental scientific discoveries and the great body of 1 ALLEN I. LASKIN 2 continuing research that forms that basis for the technology is often obscured.

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Content:
Front Matter....Pages i-x
Introduction....Pages 1-7
Computer Applications in Recombinant DNA Research....Pages 9-15
Human Immune Interferon (IFN-?) Gene Sequence and Structure....Pages 17-34
Correction of Inborn Errors of Metabolism by Bone Marrow Transplant....Pages 35-61
Research on Gene Therapy....Pages 63-76
Monoclonal Antibody for the Protection of Neonatal Pigs and Calves from Toxic Diarrhea....Pages 77-92
Monoclonal Antibodies as Physiologic Probes....Pages 93-99
Novel Applications of Monoclonal Antibodies....Pages 101-128
Biotechnology for Agriculture Overview by Convener....Pages 129-154
The Use of Ti-Plasmids for the Genetic Engineering of Plants....Pages 155-158
New Developments in Plant Tissue Culture and Plant Regeneration....Pages 159-171
Drugs and Antibiotics: An Overview Chairman’s Comments....Pages 173-193
Design and Synthesis of Optically-Pure Compounds Using Microbial Systems....Pages 195-209
Mutasynthesis and Directed Biosynthesis for the Production of New Antibiotics....Pages 211-214
Host/Vector Systems for Actinomycetes and Applications to Strain Development....Pages 215-230
Suicide Enzyme Inactivators....Pages 231-269
Prospects for Chemicals and Fuels Production by Fermentation....Pages 271-285
The Utilization of Inorganic Pyrophosphate, Tripolyphosphate, and Tetrapolyphosphate as Energy Sources for the Growth of Anaerobic Bacteria....Pages 287-305
Genetic Strategies in Strain Design for Fermentations....Pages 307-316
Anaerobic Production of Chemicals....Pages 317-348
Continuous Culture for Production....Pages 349-376
The Obligate Methane-Oxidizing Bacteria and Their Biotechnological Potential....Pages 377-403
Biodegradation and Enzyme Technology....Pages 405-437
Industrial Production of Optically Active Compounds Using Immobilized Biocatalysts....Pages 439-460
Unconventional Catalytic Properties of Conventional Enzymes: Applications in Organic Chemistry....Pages 461-463
Correlation Between Spontaneous Phenotypic Changes in Pseudomonas Strains with Changes in the Structure of Catabolic Plasmids: Experiences with TOL Plasmids....Pages 465-496
Closing Remarks....Pages 497-518
Back Matter....Pages 519-552
....Pages 553-555