Ebook: Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology

Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.

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Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.

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Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.
Content:
Front Matter....Pages i-xxi
Front Matter....Pages 1-1
Introduction....Pages 3-13
The STIM-Orai Pathway....Pages 15-31
The STIM-Orai Pathway....Pages 33-44
The STIM-Orai Pathway....Pages 45-56
STIM-TRP Pathways....Pages 57-72
STIM-TRP Pathways....Pages 73-92
Microdomain Organization and the Role of Second Messengers....Pages 93-113
Microdomain Organization and the Role of Second Messengers....Pages 115-130
Front Matter....Pages 131-131
Introduction....Pages 133-135
New Aspects of the Contribution of ER to SOCE Regulation....Pages 137-151
New Aspects of the Contribution of ER to SOCE Regulation....Pages 153-162
New Aspects of the Contribution of ER to SOCE Regulation....Pages 163-175
The Role of Mitochondria in the Activation/Maintenance of SOCE....Pages 177-192
The Role of Mitochondria in the Activation/Maintenance of SOCE....Pages 193-209
The Role of Mitochondria in the Activation/Maintenance of SOCE....Pages 211-229
Tissue Specificity....Pages 231-247
Tissue Specificity....Pages 249-263
Front Matter....Pages 265-265
Introduction....Pages 267-269
Immune System....Pages 271-299
Cardiovascular System....Pages 301-325
Front Matter....Pages 265-265
Cardiovascular System....Pages 327-346
Cardiovascular System....Pages 347-361
Cardiovascular System....Pages 363-376
Cardiovascular System....Pages 377-396
Cardiovascular System....Pages 397-416
Nervous System....Pages 417-434
Skeletal Muscle....Pages 435-447
Skeletal Muscle....Pages 449-460
Reproductive System....Pages 461-473
Back Matter....Pages 475-481

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Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.
Content:
Front Matter....Pages i-xxi
Front Matter....Pages 1-1
Introduction....Pages 3-13
The STIM-Orai Pathway....Pages 15-31
The STIM-Orai Pathway....Pages 33-44
The STIM-Orai Pathway....Pages 45-56
STIM-TRP Pathways....Pages 57-72
STIM-TRP Pathways....Pages 73-92
Microdomain Organization and the Role of Second Messengers....Pages 93-113
Microdomain Organization and the Role of Second Messengers....Pages 115-130
Front Matter....Pages 131-131
Introduction....Pages 133-135
New Aspects of the Contribution of ER to SOCE Regulation....Pages 137-151
New Aspects of the Contribution of ER to SOCE Regulation....Pages 153-162
New Aspects of the Contribution of ER to SOCE Regulation....Pages 163-175
The Role of Mitochondria in the Activation/Maintenance of SOCE....Pages 177-192
The Role of Mitochondria in the Activation/Maintenance of SOCE....Pages 193-209
The Role of Mitochondria in the Activation/Maintenance of SOCE....Pages 211-229
Tissue Specificity....Pages 231-247
Tissue Specificity....Pages 249-263
Front Matter....Pages 265-265
Introduction....Pages 267-269
Immune System....Pages 271-299
Cardiovascular System....Pages 301-325
Front Matter....Pages 265-265
Cardiovascular System....Pages 327-346
Cardiovascular System....Pages 347-361
Cardiovascular System....Pages 363-376
Cardiovascular System....Pages 377-396
Cardiovascular System....Pages 397-416
Nervous System....Pages 417-434
Skeletal Muscle....Pages 435-447
Skeletal Muscle....Pages 449-460
Reproductive System....Pages 461-473
Back Matter....Pages 475-481
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