Ebook: Molecular Theory of the Living Cell: Concepts, Molecular Mechanisms, and Biomedical Applications

The book presents the first comprehensive molecular theory of the living cell ever published since the cell doctrine was formulated in 1838-1839. It introduces into cell biology over thirty key concepts, principles and laws imported from physics, chemistry, computer science, linguistics, semiotics and philosophy. The author formulates physically, chemically and enzymologically realistic molecular mechanisms to account for basic living processes such as ligand-receptor interactions, enzymic catalysis, force-generating mechanisms in molecular motors, chromatin remodelling, and signal transduction. Possible solutions to basic and practical problems facing contemporary biology and biomedical sciences have been suggested, including pharmacotherapeutics and personalized medicine.

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This book presents a comprehensive molecular theory of the living cell based on over thirty concepts, principles and laws imported from thermodynamics, statistical mechanics, quantum mechanics, chemical kinetics, informatics, computer science, linguistics, semiotics, and philosophy. The author formulates physically, chemically and enzymologically realistic molecular mechanisms to account for the basic living processes such as ligand-receptor interactions, protein folding, single-molecule enzymic catalysis, force-generating mechanisms in molecular motors, signal transduction, regulation of the genome-wide RNA metabolism, morphogenesis, the micro-macro coupling in coordination dynamics, the origin of life, and the mechanisms of biological evolution itself. Possible solutions to basic and practical problems facing contemporary biology and biomedical sciences have been suggested, including pharmacotheragnostics and personalized medicine.

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This book presents a comprehensive molecular theory of the living cell based on over thirty concepts, principles and laws imported from thermodynamics, statistical mechanics, quantum mechanics, chemical kinetics, informatics, computer science, linguistics, semiotics, and philosophy. The author formulates physically, chemically and enzymologically realistic molecular mechanisms to account for the basic living processes such as ligand-receptor interactions, protein folding, single-molecule enzymic catalysis, force-generating mechanisms in molecular motors, signal transduction, regulation of the genome-wide RNA metabolism, morphogenesis, the micro-macro coupling in coordination dynamics, the origin of life, and the mechanisms of biological evolution itself. Possible solutions to basic and practical problems facing contemporary biology and biomedical sciences have been suggested, including pharmacotheragnostics and personalized medicine.

Content:
Front Matter....Pages i-xxi
Front Matter....Pages 5-5
Introduction....Pages 1-3
Front Matter....Pages 5-5
Physics....Pages 7-67
Chemistry....Pages 69-84
Biology....Pages 85-118
Engineering....Pages 119-157
Linguistics, Semiotics, and Philosophy....Pages 159-199
Front Matter....Pages 201-201
Molecular Mechanisms: From Enzymes to Evolution....Pages 203-230
The Conformon....Pages 231-253
Intracellular Dissipative Structures (IDSs)....Pages 255-268
The Living Cell....Pages 269-293
Front Matter....Pages 295-295
Subcellular Systems....Pages 297-390
Whole Cells....Pages 391-477
Mechanisms of the Origin of Life....Pages 479-485
Principles and Mechanisms of Biological Evolution....Pages 487-519
Multicellular Systems....Pages 521-571
What Is Life?....Pages 573-583
Why Is the Cell So Complex?....Pages 585-598
The Knowledge Uncertainty Principle in Biomedical Sciences....Pages 599-606
Back Matter....Pages 607-620
Towards a Category Theory of Everything (cTOE)....Pages 621-631
....Pages 643-748