Ebook: Power Laws, Scale-Free Networks and Genome Biology
- Tags: Biophysics/Biomedical Physics, Bioinformatics, Biochemistry general, Microbial Genetics and Genomics, Proteomics, Physics general
- Series: Molecular Biology Intelligence Unit
- Year: 2006
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena.
Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena.
Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena.
Content:
Front Matter....Pages i-xix
Power Laws in Biological Networks....Pages 1-11
Graphical Analysis of Biocomplex Networks and Transport Phenomena....Pages 12-24
Large-Scale Topological Properties of Molecular Networks....Pages 25-39
The Connectivity of Large Genetic Networks....Pages 40-52
The Drosophila Protein Interaction Network May Be neither Power-Law nor Scale-Free....Pages 53-64
Birth and Death Models of Genome Evolution....Pages 65-85
Scale-Free Evolution....Pages 86-105
Gene Regulatory Networks....Pages 106-122
Power Law Correlations in DNA Sequences....Pages 123-164
Analytical Evolutionary Model for Protein Fold Occurrence in Genomes, Accounting for the Effects of Gene Duplication, Deletion, Acquisition and Selective Pressure....Pages 165-193
The Protein Universes....Pages 194-205
The Role of Computation in Complex Regulatory Networks....Pages 206-225
Neutrality and Selection in the Evolution of Gene Families....Pages 226-235
Scaling Laws in the Functional Content of Genomes....Pages 236-253
Back Matter....Pages 255-257
Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena.
Content:
Front Matter....Pages i-xix
Power Laws in Biological Networks....Pages 1-11
Graphical Analysis of Biocomplex Networks and Transport Phenomena....Pages 12-24
Large-Scale Topological Properties of Molecular Networks....Pages 25-39
The Connectivity of Large Genetic Networks....Pages 40-52
The Drosophila Protein Interaction Network May Be neither Power-Law nor Scale-Free....Pages 53-64
Birth and Death Models of Genome Evolution....Pages 65-85
Scale-Free Evolution....Pages 86-105
Gene Regulatory Networks....Pages 106-122
Power Law Correlations in DNA Sequences....Pages 123-164
Analytical Evolutionary Model for Protein Fold Occurrence in Genomes, Accounting for the Effects of Gene Duplication, Deletion, Acquisition and Selective Pressure....Pages 165-193
The Protein Universes....Pages 194-205
The Role of Computation in Complex Regulatory Networks....Pages 206-225
Neutrality and Selection in the Evolution of Gene Families....Pages 226-235
Scaling Laws in the Functional Content of Genomes....Pages 236-253
Back Matter....Pages 255-257
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