Ebook: Protein-Lipid Interactions: New Approaches and Emerging Concepts

Biological membranes have long been identified as key elements in a wide variety of cellular processes including cell defense communication, photosynthesis, signal transduction, and motility; thus they emerge as primary targets in both basic and applied research. This book brings together in a single volume the most recent views of experts in the area of protein–lipid interactions, providing an overview of the advances that have been achieved in the field in recent years, from very basic aspects to specialized technological applications. Topics include the application of X-ray and neutron diffraction, infrared and fluorescence spectroscopy, and high-resolution NMR to the understanding of the specific interactions between lipids and proteins within biological membranes, their structural relationships, and the implications for the biological functions that they mediate. Also covered in this volume are the insertion of proteins and peptides into the membrane and the concomitant formation of definite lipid domains within the membrane.

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Biological membranes have long been identified as key elements in a wide variety of cellular processes including cell defense communication, photosynthesis, signal transduction, and motility; thus they emerge as primary targets in both basic and applied research. This book brings together in a single volume the most recent views of experts in the area of protein–lipid interactions, providing an overview of the advances that have been achieved in the field in recent years, from very basic aspects to specialized technological applications. Topics include the application of X-ray and neutron diffraction, infrared and fluorescence spectroscopy, and high-resolution NMR to the understanding of the specific interactions between lipids and proteins within biological membranes, their structural relationships, and the implications for the biological functions that they mediate. Also covered in this volume are the insertion of proteins and peptides into the membrane and the concomitant formation of definite lipid domains within the membrane.

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Biological membranes have long been identified as key elements in a wide variety of cellular processes including cell defense communication, photosynthesis, signal transduction, and motility; thus they emerge as primary targets in both basic and applied research. This book brings together in a single volume the most recent views of experts in the area of protein–lipid interactions, providing an overview of the advances that have been achieved in the field in recent years, from very basic aspects to specialized technological applications. Topics include the application of X-ray and neutron diffraction, infrared and fluorescence spectroscopy, and high-resolution NMR to the understanding of the specific interactions between lipids and proteins within biological membranes, their structural relationships, and the implications for the biological functions that they mediate. Also covered in this volume are the insertion of proteins and peptides into the membrane and the concomitant formation of definite lipid domains within the membrane.

Content:
Front Matter....Pages I-XIV
From Lipid Phases to Membrane Protein Organization: Fluorescence Methodologies in the Study of Lipid-Protein Interactions....Pages 1-33
NMR of Membrane Proteins in Lipid Environments: the Bcl-2 Family of Apoptosis Regulators....Pages 35-61
X-ray and Neutron Diffraction Approaches to the Structural Analysis of Protein-Lipid Interactions....Pages 63-110
The Role of Proteins in the Formation of Domains in Membranes....Pages 111-126
Lateral Membrane Structure and Lipid-Protein Interactions....Pages 127-140
The Membrane as a System: How Lipid Structure Affects Membrane Protein Function....Pages 141-175
Peptide-Lipid Interaction: Shedding Light into the Mode of Action and Cell Specificity of Antimicrobial Peptides....Pages 177-201
Structural and Functional Modulation of Ion Channels by Specific Lipids: from Model Systems to Cell Membranes....Pages 203-231
Back Matter....Pages 233-235

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Biological membranes have long been identified as key elements in a wide variety of cellular processes including cell defense communication, photosynthesis, signal transduction, and motility; thus they emerge as primary targets in both basic and applied research. This book brings together in a single volume the most recent views of experts in the area of protein–lipid interactions, providing an overview of the advances that have been achieved in the field in recent years, from very basic aspects to specialized technological applications. Topics include the application of X-ray and neutron diffraction, infrared and fluorescence spectroscopy, and high-resolution NMR to the understanding of the specific interactions between lipids and proteins within biological membranes, their structural relationships, and the implications for the biological functions that they mediate. Also covered in this volume are the insertion of proteins and peptides into the membrane and the concomitant formation of definite lipid domains within the membrane.

Content:
Front Matter....Pages I-XIV
From Lipid Phases to Membrane Protein Organization: Fluorescence Methodologies in the Study of Lipid-Protein Interactions....Pages 1-33
NMR of Membrane Proteins in Lipid Environments: the Bcl-2 Family of Apoptosis Regulators....Pages 35-61
X-ray and Neutron Diffraction Approaches to the Structural Analysis of Protein-Lipid Interactions....Pages 63-110
The Role of Proteins in the Formation of Domains in Membranes....Pages 111-126
Lateral Membrane Structure and Lipid-Protein Interactions....Pages 127-140
The Membrane as a System: How Lipid Structure Affects Membrane Protein Function....Pages 141-175
Peptide-Lipid Interaction: Shedding Light into the Mode of Action and Cell Specificity of Antimicrobial Peptides....Pages 177-201
Structural and Functional Modulation of Ion Channels by Specific Lipids: from Model Systems to Cell Membranes....Pages 203-231
Back Matter....Pages 233-235
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