Ebook: Oxygen Transport To Tissue XXIII: Oxygen Measurements in the 21st Century: Basic Techniques and Clinical Relevance

The ISOTT 2001 local organizing committee was pleased to welcome over 140 delegates from around the world to the 29th annual general meeting of the International Society for Oxygen Transport to Tissue. The meeting was held in historic Philadelphia, USA, on the campus of the University of Pennsylvania from August 11 to 15, 2001. In the tradition of ISOTT, the conference was a total immersion experience. Attendees were encouraged to eat together and spend their evenings relaxing together in a style that maximized exchange of ideas and interactions of younger scientists with their more senior colleagues. Delegates participated in a total of 122 presentations including poster displays, selected oral presentations, seminars by invited speakers and a round table discussion. In choosing invited speakers and oral presenters, special emphasis was placed on methods for oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. All of the manuscripts contained in this volume underwent both an editorial and scientific review, and only those meeting both criteria have been published. However, while all efforts have been made to eliminate editorial errors, some have undoubtedly been overlooked, for which the editors apologize.

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This volume covers all aspects of oxygen delivery to tissue, including blood flow and its regulation, as well as oxygen metabolism. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This is a multidisciplinary volume designed to bring together experts and students from a range of research fields.

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This volume covers all aspects of oxygen delivery to tissue, including blood flow and its regulation, as well as oxygen metabolism. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This is a multidisciplinary volume designed to bring together experts and students from a range of research fields.
Content:
Front Matter....Pages i-xviii
The Role of Tumor Oxygenation in Vascular and Clinical Response to Angiogenesis Inhibition....Pages 1-5
Comparison of Fluctuations of Oxygen Tension in FSA, 9L, and R3230AC Tumors in Rats....Pages 7-12
Effect of Carbogen-Breathing on Redox Status of the RIF-1 Tumor....Pages 13-17
Evaluation of Microregional Variations in Tumor Hypoxia Following the Administration of Endostatin....Pages 19-24
Effect of Hydralazine on Blood Flow, Oxygenation, and Interstitial Fluid Pressure in Subcutaneous Tumors....Pages 25-29
Oxygenation of Cervix Cancers: Impact of Clinical and Pathological Parameters....Pages 31-35
Quantitative Spatial Analysis of Hypoxia and Vascular Perfusion in Tumor Sections....Pages 37-43
Tumor Oxygenation and Its Relevance to Tumor Physiology and Treatment....Pages 45-49
Mechanisms Underlying Hypoxia Development in Tumors....Pages 51-56
Lack of Association Between Tumor Hypoxia, Glut-1 Expression and Glucose Uptake in Experimental Sarcomas....Pages 57-61
The Impact of Tissue Microenvironment on Treatment Simulation....Pages 63-67
Evidence for and Against Hypoxia as the Primary Cause of Tumor Aggressiveness....Pages 69-75
Characterization of Human Gc Protein- Derived Macrophage Activation Factor (GcMAF) and Its Functional Role in Macrophage Tumoricidal Activity....Pages 77-82
Effect of Hemoglobin Solutions as Hemodiluents on Capillary Oxygen Tension....Pages 83-88
Different Efficacy in Vitro of Hemoglobin Based Oxygen Carriers and Red Cells....Pages 89-92
A Novel Blood Transfusant Candidate: Intact Human Erythrocytes Containing Hemoglobin Exclusively Nitrosylated in the ?-Subunits....Pages 93-99
Modifications of Red Blood Cell Shape and Glycoproteins Membrane Content in Septic Patients....Pages 101-107
Fiber Optic Immunosensors for Cardiovascular Disease Diagnosis....Pages 109-114
Soft Gel Chromatography Column Analysis and Design for the Production of High Molecular Weight Blood Factors: Model Molecule Protein C....Pages 115-119
Development of an Economic Miniantibody Production Process for the Purification of Protein C (Anti-Coagulant/Anti-Thrombotic)....Pages 121-125
Nitric Oxide Synthesis in Brain is Stimulated By Oxygen....Pages 127-131
Oxygen Indirectly Regulates Nitric Oxide Availability....Pages 133-137
Modeling the Regulation of Oxygen Consumption By Nitric Oxide....Pages 139-143
Oxygen Sensor Design: Analysis and Correction of Problems Associated with Zero Current, Stability and Structure....Pages 145-149
Computer Simulation of Oxygen Microelectrode Measurements in Tissues....Pages 151-156
Physiological Oxygen Measurements Using Oxygen Electrodes....Pages 157-161
Accuracy of a Polarographic Electrode at High Oxygen Concentrations....Pages 163-167
Oxygen Distributions in Tissue Measured by Phosphorescence Quenching....Pages 169-173
Adapting and Validating a NIRS Device to Measure in Utero Fetal Sheep Cerebral Oxygenation....Pages 175-179
Detection of the Fast Neuronal Signal on the Motor Cortex Using Functional Frequency Domain near Infrared Spectroscopy....Pages 181-185
Probing Rat Brain Oxygenation with Near-Infrared Spectroscopy (NIRS) and Magnetic Resonance Imaging (MRI)....Pages 187-192
Variation in Blood Oxygenation and Cerebral pO2 in a Mouse Model Measured by EPR Spectrometry....Pages 193-197
Functional Oxygen-17 Magnetic Resonance Imaging and Localized Spectroscopy....Pages 199-204
Development of a Retractor for Monitoring the Oxygenation State of Brain Tissue....Pages 205-211
Mapping of Hemodynamics on the Human Calf with Near Infrared Spectroscopy and the Influence of the Adipose Tissue Thickness....Pages 213-218
EPR Imaging of Vascular Changes in Oxygen in Response to Carbogen Breathing....Pages 219-223
Molecular Imaging by PET....Pages 225-230
Frequency Domain Imaging of Oxygen Tension in the Mouse Retina....Pages 231-236
Oxygen Delivery to the Retina and Related Visual Pathology....Pages 237-241
Activation of the Visual Cortex in Newborn Infants Under Natural Sleep Using Multichannel Near-Infrared Spectroscopy....Pages 243-247
Effect of Blood Flow on PvO2-VO2 Relation in Contracting In Situ Skeletal Muscle....Pages 249-254
Oxygen Transport and Intracellular Bioenergetics on Stimulated Cat Skeletal Muscle....Pages 255-259
Muscle Oxygenation by Near Infrared Spectroscopy and Lactate Thresholds in Endurance Trained and Recreationally Active Cyclists....Pages 261-265
Cardiac Output, Oxygen Consumption and Muscle Oxygen Delivery in Submaximal Exercise....Pages 267-272
Non-Invasive PET and Spect Imaging of Tissue Hypoxia Using Isotopically Labeled 2-Nitroimidazoles....Pages 273-278
Diffuse Optical Measurement of Hemoglobin and Cerebral Blood Flow in Rat Brain During Hypercapnia, Hypoxia and Cardiac Arrest....Pages 279-284
Multiorgan Monitoring of Hemodynamic and Mitochondrial Responses to Anoxia and Cardiac Arrest in the Rat....Pages 285-292
Importance of Glomus Cell Plasma Membrane and Mitochondrial Membrane Potentials During Acute Hypoxia Signaling in the Rat Carotid Body....Pages 293-297
Estimation of Hydroxyl Radicals Based on the Salicylate Trapping Method in Hippocampus of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) During Transient Ischemia and Recirculation....Pages 299-304
Effect of Hypoxia and Ischemia on Expression of Selected Genes in Brain of Newborn Piglets....Pages 305-311
Brain Oxygenation During Cardiopulmonary Bypass and Circulatory Arrest....Pages 313-317
Expression of Angiopoietin-1 and -2 in the Rat Brain During Chronic Hypoxia and De-Adaptation....Pages 319-324
Hypoxia-Inducible Factor-1? Accumulation in the Rat Brain in Response to Hypoxia and Ischemia is Attenuated During Aging....Pages 325-330
Lung Ischemia: Endothelial Cell Signaling by Reactive Oxygen Species....Pages 331-335
Near Infrared Spectroscopy (NIRS) Measurements During Global Cerebral Ischemia in Sheep....Pages 337-341
Simulations of Capillary Network Oxygen Transport During Transient Ischemia in the Presence and Absence of Tissue Myoglobin....Pages 343-347
Cerebral Oxygenation During Chronic Obstructive Pulmonary Disease....Pages 349-354
Physiology of Functional Activation....Pages 355-359
Nonlinear Analysis of Heart Rate Variability in Infants with Apparent Life- Threatening Events....Pages 361-364
The Effect of Nicotinamide & Hyperoxic Gases on Blood Glucose....Pages 365-368
Measurement of Tissue Oxygenation Index During the First Three Days in Premature Born Infants....Pages 369-373
Simultaneous Measurement of Cerebral Tissue Oxygenation over the Adult Frontal and Motor Cortex During Rest and Functional Activation....Pages 375-378
Dysfunctional Microvascular Conducted Response in Irradiated Normal Tissue....Pages 379-383
Oxygenation and Blood Concentration Changes in Human Subject Prefrontal Activation by Anagram Solutions....Pages 385-389
Quantitation of the Concordance Between Cerebral Intravascular Oxygenation and Mean Arterial Blood Pressure for the Detection of Impaired Autoregulation....Pages 391-395
Back Matter....Pages 397-401
....Pages 403-408