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Biological systems are regulated by the thermodynamic parameters of pressure and temperature. With the help of new spectroscopic methods it is now possible to study the structure and function of such systems under extreme pressures and temperatures. This book described the resulting theory and applications of these pressure and temperature effects. The subjects covered include the use of high pressure in food processing and even the theory of the origin and evolution of life. Readers exploring the world of biology in extreme environments will find this book particularly useful.




Biological systems are regulated by the thermodynamic parameters of pressure and temperature. With the help of new spectroscopic methods it is now possible to study the structure and function of such systems under extreme pressures and temperatures. This book described the resulting theory and applications of these pressure and temperature effects. The subjects covered include the use of high pressure in food processing and even the theory of the origin and evolution of life. Readers exploring the world of biology in extreme environments will find this book particularly useful.


Biological systems are regulated by the thermodynamic parameters of pressure and temperature. With the help of new spectroscopic methods it is now possible to study the structure and function of such systems under extreme pressures and temperatures. This book described the resulting theory and applications of these pressure and temperature effects. The subjects covered include the use of high pressure in food processing and even the theory of the origin and evolution of life. Readers exploring the world of biology in extreme environments will find this book particularly useful.
Content:
Front Matter....Pages I-XII
Liquid Water at Low Temperature: Clues for Biology?....Pages 1-23
Ab Initio Theoretical Study of Water: Extension to Extreme Conditions....Pages 25-52
The Behavior of Proteins Under Extreme Conditions: Physical Concepts and Experimental Approaches....Pages 53-73
High-Pressure NMR Spectroscopy of Proteins....Pages 75-100
Pressure-Induced Secondary Structural Changes of Proteins Studied by FTIR Spectroscopy....Pages 101-120
The Small-Angle X-Ray Scattering from Proteins Under Pressure....Pages 121-138
Accurate Calculations of Relative Melting Temperatures of Mutant Proteins by Molecular Dynamics/Free Energy Perturbation Methods....Pages 139-165
Enzyme Kinetics: Stopped-Flow Under Extreme Conditions....Pages 167-185
Pressure Effects on the Intramolecular Electron Transfer Reactions in Hemoproteins....Pages 187-203
Marine Microbiology: Deep Sea Adaptations....Pages 205-220
Submarine Hydrothermal Vents as Possible Sites of the Origin of Life....Pages 221-238
The Effect of Hydrostatic Pressure on the Survival of Microorganisms....Pages 239-256
Dynamics of Cell Structure by Pressure Stress in the Fission Yeast Schizosaccharomyces pombe ....Pages 257-277
Back Matter....Pages 279-283


Biological systems are regulated by the thermodynamic parameters of pressure and temperature. With the help of new spectroscopic methods it is now possible to study the structure and function of such systems under extreme pressures and temperatures. This book described the resulting theory and applications of these pressure and temperature effects. The subjects covered include the use of high pressure in food processing and even the theory of the origin and evolution of life. Readers exploring the world of biology in extreme environments will find this book particularly useful.
Content:
Front Matter....Pages I-XII
Liquid Water at Low Temperature: Clues for Biology?....Pages 1-23
Ab Initio Theoretical Study of Water: Extension to Extreme Conditions....Pages 25-52
The Behavior of Proteins Under Extreme Conditions: Physical Concepts and Experimental Approaches....Pages 53-73
High-Pressure NMR Spectroscopy of Proteins....Pages 75-100
Pressure-Induced Secondary Structural Changes of Proteins Studied by FTIR Spectroscopy....Pages 101-120
The Small-Angle X-Ray Scattering from Proteins Under Pressure....Pages 121-138
Accurate Calculations of Relative Melting Temperatures of Mutant Proteins by Molecular Dynamics/Free Energy Perturbation Methods....Pages 139-165
Enzyme Kinetics: Stopped-Flow Under Extreme Conditions....Pages 167-185
Pressure Effects on the Intramolecular Electron Transfer Reactions in Hemoproteins....Pages 187-203
Marine Microbiology: Deep Sea Adaptations....Pages 205-220
Submarine Hydrothermal Vents as Possible Sites of the Origin of Life....Pages 221-238
The Effect of Hydrostatic Pressure on the Survival of Microorganisms....Pages 239-256
Dynamics of Cell Structure by Pressure Stress in the Fission Yeast Schizosaccharomyces pombe ....Pages 257-277
Back Matter....Pages 279-283
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