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Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion (Molecular Interactions of Actin. Actin-Myosin Interaction, Actin-Based Regulation) provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data.
This book will appeal to research scientists seeking contemporary overviews of actin and its binding proteins. Contributors include senior scientists as well as the new breed of younger scientists.




Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion (Molecular Interactions of Actin. Actin-Myosin Interaction, Actin-Based Regulation) provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data.
This book will appeal to research scientists seeking contemporary overviews of actin and its binding proteins. Contributors include senior scientists as well as the new breed of younger scientists.


Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion (Molecular Interactions of Actin. Actin-Myosin Interaction, Actin-Based Regulation) provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data.
This book will appeal to research scientists seeking contemporary overviews of actin and its binding proteins. Contributors include senior scientists as well as the new breed of younger scientists.
Content:
Front Matter....Pages I-XII
An Overview of Actin Structure and Actin-Binding Proteins....Pages 1-7
A Historical Perspective of Actin Assembly and Its Interactions....Pages 9-21
Divalent Cations, Nucleotides, and Actin Structure....Pages 23-41
The Helical Parameters of F-Actin Precisely Determined from X-Ray Fiber Diffraction of Well-Oriented Sols....Pages 43-58
Analysis of Models of F-Actin Using Fluorescence Resonance Energy Transfer Spectroscopy....Pages 59-77
Microscopic Analysis of Polymerization and Fragmentation of Individual Actin Filaments....Pages 79-94
Two Conformations of G-Actin Related to Two Conformations of F-Actin....Pages 95-101
Actin Structure Function Relationships Revealed by Yeast Molecular Genetics....Pages 103-121
Actin-Binding Proteins: An Overview....Pages 123-134
The ADF/Cofilin Family: Accelerators of Actin Reorganization....Pages 135-154
Predicting Interaction Sites between Glycolytic Enzymes and Cytoskeletal Proteins Employing the Concepts of the Molecular Recognition Theory....Pages 155-164
Regulation of the Cytoskeleton Assembly: a Role for a Ternary Complex of Actin with Two Actin-Binding Proteins....Pages 165-179
Actin Filament Networks....Pages 181-199
Structure and Function of Gelsolin....Pages 201-211
Arps: Actin-Related Proteins....Pages 213-229
Control of the Actin Cytoskeleton by Extracellular Signals....Pages 231-262
Back Matter....Pages 263-269


Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion (Molecular Interactions of Actin. Actin-Myosin Interaction, Actin-Based Regulation) provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data.
This book will appeal to research scientists seeking contemporary overviews of actin and its binding proteins. Contributors include senior scientists as well as the new breed of younger scientists.
Content:
Front Matter....Pages I-XII
An Overview of Actin Structure and Actin-Binding Proteins....Pages 1-7
A Historical Perspective of Actin Assembly and Its Interactions....Pages 9-21
Divalent Cations, Nucleotides, and Actin Structure....Pages 23-41
The Helical Parameters of F-Actin Precisely Determined from X-Ray Fiber Diffraction of Well-Oriented Sols....Pages 43-58
Analysis of Models of F-Actin Using Fluorescence Resonance Energy Transfer Spectroscopy....Pages 59-77
Microscopic Analysis of Polymerization and Fragmentation of Individual Actin Filaments....Pages 79-94
Two Conformations of G-Actin Related to Two Conformations of F-Actin....Pages 95-101
Actin Structure Function Relationships Revealed by Yeast Molecular Genetics....Pages 103-121
Actin-Binding Proteins: An Overview....Pages 123-134
The ADF/Cofilin Family: Accelerators of Actin Reorganization....Pages 135-154
Predicting Interaction Sites between Glycolytic Enzymes and Cytoskeletal Proteins Employing the Concepts of the Molecular Recognition Theory....Pages 155-164
Regulation of the Cytoskeleton Assembly: a Role for a Ternary Complex of Actin with Two Actin-Binding Proteins....Pages 165-179
Actin Filament Networks....Pages 181-199
Structure and Function of Gelsolin....Pages 201-211
Arps: Actin-Related Proteins....Pages 213-229
Control of the Actin Cytoskeleton by Extracellular Signals....Pages 231-262
Back Matter....Pages 263-269
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