Ebook: Oxygen Transport to Tissue XX

''In addition to a wide variety of traditional oxygen transport topics, particular areas have been selected for emphasis at the 1997 meeting, which are:

• Molecular and genetic techniques to study oxygen transport in health and disease
• Angiogenesis during hypoxia, ischemia, and development
• Physiological mechanisms of oxygen sensing
• Physiological fluctuations of cerebral blood flow, metabolism and oxygenation
• Near infrared and phsophorescence techniques for the assessment of blood and tissue oxygenation
• Advances in biotechnology of anticoagulants and blood substitutes.

'' (excerpted from the Preface).

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Content:
Front Matter....Pages i-xx
The Genesis of Isott....Pages 1-6
Oxygen and Ion Concentrations in Normoxic and Hypoxic Brain Cells....Pages 7-16
Uses of High Altitude for Studies of Effects of Hypoxia....Pages 17-28
A Proposal for Analysing the Acid-Base Balance at Steady State in Vivo....Pages 29-34
Diffusion Shunts for Oxygen....Pages 35-44
Response of Muscle Oxygen Saturation to Exercise, Measured with Near Infrared Spectrophotometry in Patients with Peripheral Vascular Disease....Pages 45-52
Possibility of Monitoring Mitochondrial Activity in Isometric Exercise using Nirs....Pages 53-62
Muscle Deoxygenation in Aerobic and Anaerobic Exercise....Pages 63-70
Sublobular Distribution of Cytochromes in Cold-Stored Rat Liver....Pages 71-82
In Vivo Analysis of Hepatic NADH Fluorescence....Pages 83-89
Gaseous Oxygenation of the Ischemic Rat Liver....Pages 91-94
A Correlation of Intravital Microscopically Assessed NADH Fluorescence, Tissue Oxygenation, and Organ Function During Shock and Resuscitation of the Rat Liver....Pages 95-101
Bold MRI vs. NIR Spectrophotometry....Pages 103-113
Characterization of the Pulse Signal over the Human Head by Near Infrared Spectroscopy....Pages 115-123
Comparison of Absolute Cerebral Haemoglobin Concentration in Neonates Measured Directly and by the Oxygen Swing Method Both Based on Near Infrared Spectrophotometry....Pages 125-129
Evaluation of Near Infrared Spectroscopy in Patients with Traumatic Brain Injury....Pages 131-137
Spectroscopic Investigation of Reflectance Changes in the Barrel Cortex Following Whisker Stimulation....Pages 139-148
Near-Simultaneous Hemoglobin Saturation and Oxygen Tension Maps in the Mouse Cortex During Amphetamine Stimulation....Pages 149-158
Simultaneous Tissue PO2, Nitric Oxide, and Laser Doppler Blood Flow Measurements During Neuronal Activation of Optic Nerve....Pages 159-164
Nitric Oxide and Circulatory Shock....Pages 165-172
Effect of Hemorrhagic Hypotension on Hydroxyl Radicals in Cat Brain....Pages 173-180
Direct Detection of Tissue Nitric Oxide in Septic Mice....Pages 181-187
Intestinal Micro Vascular PO2 Measurement with Pd-Porphyrin Phosphorescence in the Mechanically Ventilated Mouse....Pages 189-193
Peroxynitrite Reacts with Methemoglobin to Generate Globin-Bound free Radical Species....Pages 195-202
Adaptation of Hearts to Chronic Hypoxia Increases Tolerance to Subsequent Ischemia by Increased Nitric Oxide Production....Pages 203-217
Involvement of the Oxygen Storage Protein Myoglobin in Muscle Damage under Oxidative Stress....Pages 219-223
Hypoxic Renal Tissue Damage by Endothelin-Mediated Arterial Vasoconstriction During Radioangiography in Man....Pages 225-234
Functional And Basal Cerebral Metabolic Rate For Oxygen (CMRO2) and its Relevance to the Pathogenesis and Therapy of Brain Injury....Pages 235-242
Developing in Vivo EPR Oximetry for Clinical use....Pages 243-252
Regional Cerebral Blood Flow Autoregulation in a Silicone Embolus Model of Focal Brain Ischemia as Assessed by Multichannel Laser Doppler Flowmetry....Pages 253-259
Oxygen Delivery to and Use by Primary Porcine Hepatocytes in the HepatAssist™ 2000 System For Extracorporeal Treatment of Patients in End-Stage Liver Failure....Pages 261-271
Mechanisms of Anoxia Tolerance....Pages 273-280
Ischemia-Induced Coronary Collateral Angiogenesis....Pages 281-286
Hypoxia-Induced Brain Angiogenesis....Pages 287-293
On the Possible Role of Reactive Oxygen Species in Angiogenesis....Pages 295-310
Expression and Response to Hypoxia of Vascular Endothelial Growth Factor (VEGF) in Rat and Rabbit Tissues....Pages 311-317
Increase of Neuronal Nitric Oxide Synthase During Chronic Hypoxia....Pages 319-323
Chronic Radiation Bone Toxicity is Associated with Decreased Perfusion without Elevation of Circulating or Soft Tissue TGF? or TNF?....Pages 325-333
Simultaneous in Vivo Investigation of Structural and Functional Parameters in a Growing Vascular System....Pages 335-342
Age-Related Changes in the Microcirculation of Skeletal Muscle....Pages 343-348
Remodeling of the Leptomeningeal Micro Vascular Plexus in Neonatal Rats....Pages 349-354
Overview of Microcirculatory Oxygen Measurements and their Contribution to our Understanding of Oxygen Delivery to Tissue....Pages 355-360
Comparing Tissue PO2 Measurements by Recessed Microelectrode and Phosphorescence Quenching....Pages 361-365
Interpretation of Phosphorescence Quenching Measurements Made in the Presence of Oxygen Gradients....Pages 367-374
Choroidal Regulation of Oxygen Supply to the Guinea Pig Retina....Pages 375-383
A First Estimate of the Effect of Catchment Area on pO2 Histograms Derived from O2MB Saturation Measurements....Pages 385-389
Membranes....Pages 391-397
Direct Estimation of Intracellular Po2 Gradients in a Single Cardiomyocyte of the Rat....Pages 399-408
Are there Significant Gradients of PO2 in Cells?....Pages 409-413
Problems in Precise Measurement of Tidal Volumes....Pages 415-423
Peep Decreases Oxygenation of the Intestinal Mucosa Despite Normalization of Cardiac Output....Pages 425-433
Hyperbaric Oxygen....Pages 435-440
Tissue Oxygen Sensing and the Carotid Body....Pages 441-445
Vascular and Metabolic Effects of Nitric Oxide Synthase Inhibition Evaluated by Tissue PO2 Measurements in Carotid Body....Pages 447-454
Local Injection of NaCN into the Nucleus Locus Ceruleus of the Rat Brain Induces Respiratory Depression....Pages 455-460
Selective Hypoxic Loading of the Ventrolateral Medulla Inhibits Cholinergic Outflow to the Airways....Pages 461-465
Simple Model Analysis of 13C NMR Spectra to Measure Oxygen Consumption Using Frozen Tissue Samples....Pages 467-473
Reflectance Measurement of Heart Muscle Oxygenation....Pages 475-485
Response Time of Myocardial Oxygen Consumption to Cardiac Work Jumps at 28°C Varies with Exogenous Carbon Substrate....Pages 487-500
Myoglobin Function Evaluated in Working Heart Tissue....Pages 501-508
Papillary Muscle and Left Ventricle Show Different Contractile and Metabolic Responses During Myocardial Stunning....Pages 509-517
RSR13, a Synthetic Allosteric Modifier of Hemoglobin, Enhances Recovery of Stunned Myocardium in Dogs....Pages 519-525
Prior Preconditioning by Ischemia or Sevoflurane Improves Cardiac Work Per Oxygen Use in Isolated Guinea Pig Hearts After Global Ischemia....Pages 527-531
Optimizing the Oxygen Balance During Initial Reperfusion with 2,3-Butanedione Monoxime Attenuates Cardiac Reperfusion Injury....Pages 533-542
Spontaneous Fluctuations in Cerebral Oxygen Supply....Pages 543-550
Slow Oscillations of Cytochrome Oxidase Redox State and Blood Volume in Unanesthetized Cat and Rabbit Cortex....Pages 551-559
Non-Linear Analysis of Vasomotion Oscillations in Reflected Light Measurements....Pages 561-570
Clinical Application of Basal Regional Cerebral Blood flow Fluctuation Measurements by FMRI....Pages 571-582
Current Status of Knowledge and Critical Issues in Tumor Oxygenation....Pages 583-590
Oxygen Distributions within R3230AC Tumors Growing in Dorsal Flap Window Chambers in Rats*....Pages 591-602
Co-Localization of Hypoxia and Apoptosis in Irradiated and Untreated HCT116 Human Colon Carcinoma Xenografts....Pages 603-609
Effect of Local Irradiation on Tumor Oxygenation, Perfused Vessel Density, and Development of Hypoxia....Pages 611-618
Theoretical Simulation of Oxygen Transport to Tumors by Three-Dimensional Networks of Microvessels....Pages 619-628
Oxygen Tension in Human Squamous Cell Carcinoma and Adenocarcinoma of the Uterine Cervix....Pages 629-634
Use of Oxygen-15-Labeled Molecular Oxygen for Oxygen Delivery Studies of Blood and Blood Substitutes....Pages 635-641
Effect of RSR13 on Temperature-Dependent Changes in Hemoglobin Oxygen Affinity of Human Whole Blood....Pages 643-652
The Effect of Losartan on red Blood Cell Deformability and Tissue Oxygenation in Patients with Arterial Hypertension....Pages 653-661
Pro-/Anti-Coagulants and Oxygen Transport in Tissue....Pages 663-666
Heterogeneity (DVT) Depth Determination Using Phase Shift and Time Constant Values from NIR-TRS Spectra....Pages 667-670
Preliminary Study of Biosensor Optimization for the Detection of Protein C....Pages 671-679
Gel Compression Considerations for Chromatography Scale-Up for Protein C Purification....Pages 681-688
Protein C Separation from Human Blood Plasma Cohn Fraction IV-1 Using Immobilized Metal Affinity Chromatography....Pages 689-696
Back Matter....Pages 697-704
....Pages 705-706