Ebook: Gene Therapy of Cancer

The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.

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The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.

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The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.
Content:
Front Matter....Pages i-xvi
Expression Genetics in Cancer Research, Prognosis, and Therapy....Pages 1-7
Patterns of Chromosomal Imbalances in Carcinomas of the Respiratory Tract....Pages 9-16
Inhibition of Tumorigenesis in a Murine B-Cell Lymphoma Transplant Model By c-Myc Complementary Oligonucleotides....Pages 17-22
Telomerase Inhibition by Induced Expression of Antisense RNA....Pages 23-26
Use of the IGF-I Antisense Strategy in the Treatment of the Hepatocarcinoma....Pages 27-34
Functional Involvement of CD44, a Family of Cell Adhesion Molecules, in Immune Responses, Tumour Progression and Haematopoiesis....Pages 35-42
The Influence of CD44 Splice Variants to the Outcome of Patients with Oral Squamous Cell Carcinoma....Pages 43-49
Control of Tumor Growth Via Inhibition of Tumor Angiogenesis....Pages 51-55
Expression of Collagenase-3 (MMP-13) by Tumor Cells in Squamous Cell Carcinomas of the Head and Neck....Pages 57-61
High Level Expression of Tissue Inhibitors of Metalloproteinases-1,-2 and -3 in Melanoma Cells Achieved by Adenovirus Mediated Gene Transfer....Pages 63-68
Tissue Inhibitor of Metalloproteinase Expression....Pages 69-72
Antitumor Effect of E1B Defective Adenoviruses in Human Malignant Cells....Pages 73-77
Intratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy....Pages 79-86
Sensitisation of Human Ovarian Cancer Cells to Killing by the Prodrug CB1954 Following Retroviral or Adenoviral Transfer of the E. coli Nitroreductase Gene....Pages 87-89
HSV-1 Thymidine Kinase Gene Therapy for Peritoneal Carcinomatosis....Pages 91-96
Characteristics of Cytosine Deaminase-5-Fluorocytosine System....Pages 97-106
Potentiation of the Bystander Effect by Immunization Combined With Suicide Gene Therapy....Pages 107-113
Another Mechanism Causing the Bystander Effect Besides the GAP Junction’s Role During the Glioma Gene Therapy With HSV-TK/GCV System....Pages 115-119
IL-2 Gene Transfer for Chemosensitization of Multidrug-Resistant Human Colon Carcinoma Cells....Pages 121-123
Cytotoxic Effect of Binar Cisplatin Immunoconjugate....Pages 125-131
Dietary Indole Derivatives Induce Apoptosis in Human Breast Cancer Cells....Pages 133-138
Overcoming T Cell Ignorance by Providing Costimulation....Pages 139-144
Immune Cells in the Tumor Microenvironment....Pages 145-149
Dendritic Cells Prevent CD95 Mediated T Lymphocyte Death through Costimulatory Signals....Pages 151-152
Interleukin-10 Inhibits the Immune Stimulatory Potential of Melanoma Cells Retrovirally Transduced with Human B7.1 or B7.2....Pages 153-157
Immunosuppressive Cells in Bone Marrow of Patients with Stomach Cancer....Pages 159-165
Induction of Antigen-Specific T Cells by Allogeneic CD80 Transfected Human Carcinoma Cells....Pages 167-171
IL-12-Activated NK Cells Recognize B7 Costimulatory Molecules on Tumor Cells and Autologous Dendritic Cells....Pages 173-177
Effects of Altered Antigen Processing on T-Cell Responses Toward Murine T-Lymphomas....Pages 179-188
Cancer Gene Therapy with a Heat Shock Protein Gene....Pages 189-194
Heat Shock Protein (HSP72) Surface Expression Enhances the Lysis of a Human Renal Cell Carcinoma by IL-2 Stimulated NK Cells....Pages 195-202
Identification of Epitopes for CTCL-Specific Cytotoxic T Lymphocytes....Pages 203-210
Effects of Altered Antigen Processing on H-2Dk Mediated NK Inhibition in a Murine T Lymphoma Model....Pages 211-215
Recognition of Melanoma-Associated Peptides by Peripheral Blood Mononuclear Cells of Ocular Melanoma Patients....Pages 217-223
Detection of Micrometastasis in 31 Patients with Breast Cancer by RT-PCR and Immunomagnetic Separation (ISM) Techniques....Pages 225-229
Human Tumor Immunotherapy....Pages 231-235
Modification of Cancer Vaccines by Virus Infection and Attachment of Bispecific Antibodies....Pages 237-240
Immunotherapy of Established Tumor with MHC Class II and B7.1 Cell-Based Tumor Vaccines....Pages 241-244
Retroviral B7.1 Gene Transfer in Cancer Cells Protects Cytotoxic T Cells from Deletion by “Veto” Apoptosis....Pages 245-246
Hybrid Cell Vaccination in Cancer Immunotherapy....Pages 247-250
Treatment of Hepatocellular Carcinoma with the Cellular Tumor Vaccines Generated by in Vitro Modification of Tumor Cells with Non Gene Transfer Approaches....Pages 251-257
DNA Vaccines Targeting Dendritic Cells for the Immunotherapy of Cancer....Pages 259-264
A DNA Vaccine against Malignant Melanoma Coexpressing Antigen and Cytokine....Pages 265-276
DNA Immunization in Mice against Virus-Induced Tumor Antigens....Pages 277-282
IL-4 Gene Transfer for the Treatment of Experimental Gliomas....Pages 283-293
Strategies to Elicit Anti-Idiotypic Immune Response in B-Lymphoma Patients....Pages 295-304
Autologous Fibroblasts as Potential Vehicle for Regional Ovarian Cancer Gene Therapy....Pages 305-310
Adenovirus-Mediated Ex Vivo Immunogene and in Vivo Combination Gene Therapy Strategies Induce a Systemic Anti-Tumor Immune Defense in the Mouse B16 Melanoma Model....Pages 311-314
Stable Expression of a Retrovirally Transferred Adhesion Molecule in a Human Tumor-Specific CTL Clone....Pages 315-321
?-Interferon Gene Transfer as a Therapeutic Strategy for Ovarian Cancer....Pages 323-330
Enhancement of Anti-Tumor Immunity by Injection of Fibroblasts Genetically Engineered to Produce IL-12 and to Express CD70....Pages 331-334
Sensitization of Human Cells to Lysis by Human Complement as an Approach for Cancer Gene Therapy....Pages 335-343
Targeted Adenoviral Vectors for Cancer Gene Therapy....Pages 345-348
High-Efficiency Retroviral Vector-Mediated Gene Transfer into Human T Lymphocytes....Pages 349-352
Disabled Infectious Single Cycle (DISC) Herpes Simplex Virus as a Vector for Immunotherapy of Cancer....Pages 353-357
Gene Therapy for Familial Adenomatous Polyposis....Pages 359-363
A Chimeric Fusion Protein of Cytochrome CYP4B1 and Green Fluorescent Protein for Detection of Pro-Drug Activating Gene Delivery and for Gene Therapy in Malignant Glioma....Pages 365-374
Toward Targeted Killing of Tumor-Specific Antigen-Producing Cancer Cells by Retrovirus Displaying a Single Chain Variable Fragment Antibody....Pages 375-378
A Tool for Enhancing Site-Specific Gene Integration in Mammalian Cells....Pages 379-384
Viral Particles with Heterologous Binding Motifs....Pages 385-391
Efficient Retroviral Infection of Human Cells Utilising an Adenoviral Vector Expressing the Ecotropic Receptor....Pages 393-403
Monoclonal Antibody 138H11 against Gamma-Glutamyltransferase Provides a Possible Tool for Targeting Calicheamicin ? to Renal Cell Carcinomas....Pages 405-410
Cell Cycle Regulated Promoters for the Targeting of Tumor Endothelium....Pages 411-414
Development of a Double-Copy Bicistronic Retroviral Vector for Human Gene Therapy....Pages 415-422
Gene-Modified Dendritic Cells by Receptor-Mediated Transfection....Pages 423-430
Simple and Fast Microscale Procedure for Transfection and Quantification of Reporter Gene Expression in Eukaryotic Cells....Pages 431-436
A Novel Series of Serum-Resistant Lipoaminoacid Compounds for Cellular Delivery of Plasmid DNA....Pages 437-440
Comparison of Antisense Vectors and Antisense Oligonucleotides Delivered by Means of the New Cationic Lipids Unifectin and Maxifectin....Pages 441-447
Fast-Sorting System for Cells with High-Copy-Number Expression Vectors and Its Use for the Modulation of CML Cells....Pages 449-455
Plasmid DNA for Clinical Phase I and II Studies....Pages 457-460
Large Scale Purification of Plasmid DNA for Use in Gene Therapy....Pages 461-467
Gene Marking and Gene Therapy in Multiple Myeloma....Pages 469-472
Gene Therapy for Malignant Glioma Patients....Pages 473-479
Immunization of Metastatic Breast Cancer Patients with CD80-Modified Breast Cancer Cells and GM-CSF....Pages 481-486
A Phase I Trial with a Hybrid Cell Vaccine in Patients with Metastatic Melanoma....Pages 487-492
Gene Therapy with AdV-IL2 (TG 1021) in Unresectable Digestive Adenocarcinoma....Pages 493-497
Gene Therapy with Cytokine-Transfected Xenogeneic Cells in Metastatic Tumors....Pages 499-504
Application of Gene Transfer in Cancer Immunotherapy....Pages 505-509
Active Immunization of Metastatic Melanoma Patients with IL-2 or IL-4 Gene Transfected, Allogeneic Melanoma Cells....Pages 511-518
Preparation for a Phase I/II Study Using Autologous Gene Modified T Lymphocytes for Treatment of Metastatic Renal Cancer Patients....Pages 519-525
Immunogene Therapy of Human Melanoma....Pages 527-530
Back Matter....Pages 531-537
....Pages 539-541