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This book attempts to combine many different threads into a comprehensible whole. Since the subject is the Gamma Knife and the author is a neurosurgeon, the field of clinical interest is restricted to intracranial pathology. The discipline of radiosurgery now applies to patients who may reasonably be referred by internists, neurologists, otolaryngologists, endocrinologists and several others. Some of the topics, touched upon, such as stereotaxy and the construction of a radio surgical instrument are unfamiliar to the majority of medical men. Other topics, such as those pertaining to the reactions between radiation and living tissue, are not exactly unfamiliar and yet, for most of us, they are not comfortable areas of expertise: in that we have some basic knowledge but not enough to draw conclusions and interpret. In particular, it is not easy to answer the very sensible questions that patients ask, when being considered for this particular form of treatment. The author has attempted to describe the basic relevant phenomenology in terms that should be readily understandable to a non-specialist physician. To do this, he has been heavily dependent on the expertise of a number of mathematically sophisticated collaborators, who have checked his manuscript. They are named in the acknowledgments section. The relevance of the different sections of this book will naturally be assessed differently, according to the experience and interest of the reader. To simplifY access to the information that is required, the book is divided into three main sections.








Content:
Front Matter....Pages I-XIX
Front Matter....Pages 1-1
Introduction....Pages 3-6
Principles of Stereotaxy....Pages 7-18
Ionising Radiation and Its Physical and Chemical Effects on Living Tissue....Pages 19-34
Biological Effects of Ionising Radiation....Pages 35-49
Ionising Radiation and Clinical Practice....Pages 50-54
Development of the Gamma Knife....Pages 55-65
Radiophysics, Radiobiology and the Gamma Knife....Pages 66-75
Front Matter....Pages 77-77
Gamma Knife Radiosurgery: A Patient’s Eye View....Pages 79-83
Front Matter....Pages 85-85
Diverse Clinical Aspects....Pages 87-96
Cerebral Arteriovenous Malformations....Pages 97-111
Acoustic Schwannomas....Pages 112-121
Gamma Knife Applications in and around the Pituitary Fossa....Pages 122-132
Meningiomas....Pages 133-142
Miscellaneous Indications for Gamma Knife Radiosurgery....Pages 143-152
The Future....Pages 153-155
Back Matter....Pages 157-205



Content:
Front Matter....Pages I-XIX
Front Matter....Pages 1-1
Introduction....Pages 3-6
Principles of Stereotaxy....Pages 7-18
Ionising Radiation and Its Physical and Chemical Effects on Living Tissue....Pages 19-34
Biological Effects of Ionising Radiation....Pages 35-49
Ionising Radiation and Clinical Practice....Pages 50-54
Development of the Gamma Knife....Pages 55-65
Radiophysics, Radiobiology and the Gamma Knife....Pages 66-75
Front Matter....Pages 77-77
Gamma Knife Radiosurgery: A Patient’s Eye View....Pages 79-83
Front Matter....Pages 85-85
Diverse Clinical Aspects....Pages 87-96
Cerebral Arteriovenous Malformations....Pages 97-111
Acoustic Schwannomas....Pages 112-121
Gamma Knife Applications in and around the Pituitary Fossa....Pages 122-132
Meningiomas....Pages 133-142
Miscellaneous Indications for Gamma Knife Radiosurgery....Pages 143-152
The Future....Pages 153-155
Back Matter....Pages 157-205
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