Ebook: Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy

In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.

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In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.

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In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.
Content:
Front Matter....Pages i-xvi
General Introduction....Pages 1-6
Electron Paramagnetic Resonance Theory....Pages 7-52
The Functional Structure of Human Serum Albumin....Pages 53-81
Copper Complexes of Star-Shaped Cholic Acid Oligomers With 1,2,3-Triazole Moieties....Pages 83-113
Nano-Inhomogeneities in Structure and Reactivity of Thermoresponsive Hydrogels....Pages 115-132
Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents....Pages 133-148
Local Nanoscopic Heterogeneities in Thermoresponsive Dendronized Polymers....Pages 149-172
Conclusion....Pages 173-175
Back Matter....Pages 177-212

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In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.
Content:
Front Matter....Pages i-xvi
General Introduction....Pages 1-6
Electron Paramagnetic Resonance Theory....Pages 7-52
The Functional Structure of Human Serum Albumin....Pages 53-81
Copper Complexes of Star-Shaped Cholic Acid Oligomers With 1,2,3-Triazole Moieties....Pages 83-113
Nano-Inhomogeneities in Structure and Reactivity of Thermoresponsive Hydrogels....Pages 115-132
Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents....Pages 133-148
Local Nanoscopic Heterogeneities in Thermoresponsive Dendronized Polymers....Pages 149-172
Conclusion....Pages 173-175
Back Matter....Pages 177-212
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