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Introduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson

Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. Tickle

Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. Hubbard

Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors, by Daniel F. Wyss, Yu-Sen Wang, Hugh L. Eaton, Corey Strickland, Johannes H. Voigt, Zhaoning Zhu and Andrew W. Stamford

Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery, by Michael Hennig, Armin Ruf and Walter Huber

Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery, by Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive and Marko Hyvönen

Fragment Screening and HIV Therapeutics, by Joseph D. Bauman, Disha Patel and Eddy Arnold

Fragment-Based Approaches and Computer-Aided Drug Discovery, by Didier Rognan




D. A. Erlanson Introduction to Fragment-Based Drug Discovery T. G. Davies Ian J. Tickle Fragment Screening Using X-Ray Crystallography S. Roughley L. Wright P. Brough A. Massey R. E. Hubbard Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening D. F. Wyss Y.-S. Wang H. L. Eaton C. Strickland J.s H. Voigt Z. Zhu A. W. Stamford Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors M. Hennig A. Ruf Walter HuberCombining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery E. Valkov T. Sharpe M. Marsh Sa. Greive M. Hyv?nen Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery J.h D. Bauman D. Patel E. Arnold Fragment Screening and HIV Therapeutics D. Rognan Fragment-Based Approaches and Computer-Aided Drug Discovery


D. A. Erlanson Introduction to Fragment-Based Drug Discovery T. G. Davies Ian J. Tickle Fragment Screening Using X-Ray Crystallography S. Roughley L. Wright P. Brough A. Massey R. E. Hubbard Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening D. F. Wyss Y.-S. Wang H. L. Eaton C. Strickland J.s H. Voigt Z. Zhu A. W. Stamford Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors M. Hennig A. Ruf Walter HuberCombining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery E. Valkov T. Sharpe M. Marsh Sa. Greive M. Hyv?nen Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery J.h D. Bauman D. Patel E. Arnold Fragment Screening and HIV Therapeutics D. Rognan Fragment-Based Approaches and Computer-Aided Drug Discovery
Content:
Front Matter....Pages i-xi
Introduction to Fragment-Based Drug Discovery....Pages 1-32
Fragment Screening Using X-Ray Crystallography....Pages 33-59
Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening....Pages 61-82
Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors....Pages 83-114
Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery....Pages 115-143
Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery....Pages 145-179
Fragment Screening and HIV Therapeutics....Pages 181-200
Fragment-Based Approaches and Computer-Aided Drug Discovery....Pages 201-222
Back Matter....Pages 223-225


D. A. Erlanson Introduction to Fragment-Based Drug Discovery T. G. Davies Ian J. Tickle Fragment Screening Using X-Ray Crystallography S. Roughley L. Wright P. Brough A. Massey R. E. Hubbard Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening D. F. Wyss Y.-S. Wang H. L. Eaton C. Strickland J.s H. Voigt Z. Zhu A. W. Stamford Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors M. Hennig A. Ruf Walter HuberCombining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery E. Valkov T. Sharpe M. Marsh Sa. Greive M. Hyv?nen Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery J.h D. Bauman D. Patel E. Arnold Fragment Screening and HIV Therapeutics D. Rognan Fragment-Based Approaches and Computer-Aided Drug Discovery
Content:
Front Matter....Pages i-xi
Introduction to Fragment-Based Drug Discovery....Pages 1-32
Fragment Screening Using X-Ray Crystallography....Pages 33-59
Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening....Pages 61-82
Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors....Pages 83-114
Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery....Pages 115-143
Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery....Pages 145-179
Fragment Screening and HIV Therapeutics....Pages 181-200
Fragment-Based Approaches and Computer-Aided Drug Discovery....Pages 201-222
Back Matter....Pages 223-225
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