Ebook: Neutron Scattering in Biology: Techniques and Applications
- Tags: Biophysics/Biomedical Physics, Biomedicine general, Particle Acceleration and Detection Beam Physics, Soft Matter Complex Fluids, Applied Optics Optoelectronics Optical Devices
- Series: Biological and Medical Physics Biomedical Engineering
- Year: 2006
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.
The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.
The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.
Content:
Front Matter....Pages I-XXIV
Neutron Scattering for Biology....Pages 1-18
Front Matter....Pages 19-19
Single Crystal Neutron Diffraction and Protein Crystallography....Pages 21-42
Neutron Protein Crystallography: Hydrogen and Hydration in Proteins....Pages 43-62
Neutron Protein Crystallography: Technical Aspects and Some Case Studies at Current Capabilities and Beyond....Pages 63-72
Detergent Binding in Membrane Protein Crystals by Neutron Crystallography....Pages 73-83
High-Angle Neutron Fiber Diffraction in the Study of Biological Systems....Pages 85-105
Neutron Scattering from Biomaterials in Complex Sample Environments....Pages 107-126
Small-Angle Neutron Scattering from Biological Molecules....Pages 127-160
Small Angle Neutron Scattering from Proteins, Nucleic Acids, and Viruses....Pages 161-185
Structure and Kinetics of Proteins Observed by Small Angle Neutron Scattering....Pages 187-204
Complex Biological Structures: Collagen and Bone....Pages 205-223
Structural Investigations of Membranes in Biology by Neutron Reflectometry....Pages 225-263
Protein Adsorption and Interactions at Interfaces....Pages 265-282
Complex Biomimetic Structures at Fluid Surfaces and Solid-Liquid Interfaces....Pages 283-306
Front Matter....Pages 307-307
Quasielastic Neutron Scattering in Biology, Part I: Methods....Pages 309-354
Quasielastic Neutron Scattering in Biology, Part II: Applications....Pages 355-397
Conformational Dynamics Measured with Proteins in Solution....Pages 399-418
Relating Protein Dynamics to Function and Structure: The Purple Membrane....Pages 419-434
Biomolecular Spectroscopy Using Pulsed-Source Instruments....Pages 435-460
Brownian Oscillator Analysis of Molecular Motions in Biomolecules....Pages 461-483
Front Matter....Pages 307-307
Internal Dynamics of Proteins and DNA: Analogy to Glass-Forming Systems....Pages 485-502
Structure and Dynamics of Model Membrane Systems Probed by Elastic and Inelastic Neutron Scattering....Pages 503-530
Subnanosecond Dynamics of Proteins in Solution: MD Simulations and Inelastic Neutron Scattering....Pages 531-548
Back Matter....Pages 549-557
The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.
Content:
Front Matter....Pages I-XXIV
Neutron Scattering for Biology....Pages 1-18
Front Matter....Pages 19-19
Single Crystal Neutron Diffraction and Protein Crystallography....Pages 21-42
Neutron Protein Crystallography: Hydrogen and Hydration in Proteins....Pages 43-62
Neutron Protein Crystallography: Technical Aspects and Some Case Studies at Current Capabilities and Beyond....Pages 63-72
Detergent Binding in Membrane Protein Crystals by Neutron Crystallography....Pages 73-83
High-Angle Neutron Fiber Diffraction in the Study of Biological Systems....Pages 85-105
Neutron Scattering from Biomaterials in Complex Sample Environments....Pages 107-126
Small-Angle Neutron Scattering from Biological Molecules....Pages 127-160
Small Angle Neutron Scattering from Proteins, Nucleic Acids, and Viruses....Pages 161-185
Structure and Kinetics of Proteins Observed by Small Angle Neutron Scattering....Pages 187-204
Complex Biological Structures: Collagen and Bone....Pages 205-223
Structural Investigations of Membranes in Biology by Neutron Reflectometry....Pages 225-263
Protein Adsorption and Interactions at Interfaces....Pages 265-282
Complex Biomimetic Structures at Fluid Surfaces and Solid-Liquid Interfaces....Pages 283-306
Front Matter....Pages 307-307
Quasielastic Neutron Scattering in Biology, Part I: Methods....Pages 309-354
Quasielastic Neutron Scattering in Biology, Part II: Applications....Pages 355-397
Conformational Dynamics Measured with Proteins in Solution....Pages 399-418
Relating Protein Dynamics to Function and Structure: The Purple Membrane....Pages 419-434
Biomolecular Spectroscopy Using Pulsed-Source Instruments....Pages 435-460
Brownian Oscillator Analysis of Molecular Motions in Biomolecules....Pages 461-483
Front Matter....Pages 307-307
Internal Dynamics of Proteins and DNA: Analogy to Glass-Forming Systems....Pages 485-502
Structure and Dynamics of Model Membrane Systems Probed by Elastic and Inelastic Neutron Scattering....Pages 503-530
Subnanosecond Dynamics of Proteins in Solution: MD Simulations and Inelastic Neutron Scattering....Pages 531-548
Back Matter....Pages 549-557
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