Ebook: Computational Methods in Systems Biology: 10th International Conference, CMSB 2012, London, UK, October 3-5, 2012. Proceedings

This book constitutes the thoroughly refereed conference proceedings of the 10th International Conference on Computational Methods in Systems Biology, CMSB 2012, held in London, UK, during October 3-5, 2012. The 17 revised full papers and 8 flash posters presented together with the summaries of 3 invited papers were carefully reviewed and selected from 62 submissions. The papers cover the analysis of biological systems, networks, and data ranging from intercellular to multiscale. Topics included high-performance computing, and for the first time papers on synthetic biology.

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This book constitutes the thoroughly refereed conference proceedings of the 10th International Conference on Computational Methods in Systems Biology, CMSB 2012, held in London, UK, during October 3-5, 2012. The 17 revised full papers and 8 flash posters presented together with the summaries of 3 invited papers were carefully reviewed and selected from 62 submissions. The papers cover the analysis of biological systems, networks, and data ranging from intercellular to multiscale. Topics included high-performance computing, and for the first time papers on synthetic biology.

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This book constitutes the thoroughly refereed conference proceedings of the 10th International Conference on Computational Methods in Systems Biology, CMSB 2012, held in London, UK, during October 3-5, 2012. The 17 revised full papers and 8 flash posters presented together with the summaries of 3 invited papers were carefully reviewed and selected from 62 submissions. The papers cover the analysis of biological systems, networks, and data ranging from intercellular to multiscale. Topics included high-performance computing, and for the first time papers on synthetic biology.
Content:
Front Matter....Pages -
Differential and Integral Views of Gene-Phenotype Relations: A Systems Biological Insight....Pages 1-1
Resolving the Three-Dimensional Histology of the Heart....Pages 2-16
Bimodal Protein Distributions in Heterogeneous Oscillating Systems....Pages 17-28
Expressive Statistical Model Checking of Genetic Networks with Delayed Stochastic Dynamics....Pages 29-48
Symmetry-Based Model Reduction for Approximate Stochastic Analysis....Pages 49-68
Predicting Phenotype from Genotype through Automatically Composed Petri Nets....Pages 69-86
A Simple Model to Control Growth Rate of Synthetic E. coli during the Exponential Phase: Model Analysis and Parameter Estimation....Pages 87-106
Multi-objective Optimisation, Sensitivity and Robustness Analysis in FBA Modelling....Pages 107-126
Analysis of Modular Organisation of Interaction Networks Based on Asymptotic Dynamics....Pages 127-147
Concretizing the Process Hitting into Biological Regulatory Networks....Pages 148-165
Abstraction of Graph-Based Models of Bio-molecular Reaction Systems for Efficient Simulation....Pages 166-186
Parameter Identification and Model Ranking of Thomas Networks....Pages 187-206
Investigating Co-infection Dynamics through Evolution of Bio-PEPA Model Parameters: A Combined Process Algebra and Evolutionary Computing Approach....Pages 207-226
Population Dynamics P Systems on CUDA....Pages 227-246
Approximate Bisimulations for Sodium Channel Dynamics....Pages 247-266
Efficient Handling of Large Signalling-Regulatory Networks by Focusing on Their Core Control....Pages 267-287
Sequence Dependent Properties of the Expression Dynamics of Genes and Gene Networks....Pages 288-306
Simulating Insulin Infusion Pump Risks by In-Silico Modeling of the Insulin-Glucose Regulatory System....Pages 307-321
Revisiting the Training of Logic Models of Protein Signaling Networks with ASP....Pages 322-341
JAK-STAT Signalling as Example for a Database-Supported Modular Modelling Concept....Pages 342-361
ManyCell: A Multiscale Simulator for Cellular Systems....Pages 362-365
Inferring Reaction Models from ODEs....Pages 366-369
Modelling Trafficking of Proteins within the Mammalian Cell Using Bio-PEPA....Pages 370-373
Models of Tet-On System with Epigenetic Effects....Pages 374-377
GeneFuncster: A Web Tool for Gene Functional Enrichment Analysis and Visualisation....Pages 378-381
Effects of Molecular Noise on the Multistability in a Synthetic Genetic Oscillator....Pages 382-385
Towards an Ontology of Biomodelling....Pages 386-389
Back Matter....Pages 390-393
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