Ebook: Digital Mammography: Nijmegen, 1998

In June 1998 the Fourth International Workshop on Digital Mammography was held in Nijmegen, The Netherlands, where it was hosted by the department of Radiology of the University Hospital Nijmegen. This series of meetings was initiated at the 1993 SPIE Biomedical Image Processing Conference in San Jose, USA, where a number of sessions were entirely devoted to mammographic image analysis. At very successful subsequent workshops held in York, UK (1994) and Chicago, USA (1996), the scope of the conference was broadened, establishing a platform for presentation and discussion of new developments in digital mammog­ raphy. Topics that are addressed at these meetings are computer-aided diagnosis, image processing, detector development, system design, observer performance and clinical evaluation. The goal is to bring researchers from universities, breast cancer experts, and engineers together, to exchange information and present new scientific developments in this rapidly evolving field. This book contains all the scientific papers and posters presented at the work­ shop in Nijmegen. Contributions came from as many as 20 different countries and 190 participants attended the meeting. At a technical exhibit companies demon­ strated new products and work in progress. Abstracts of all papers were reviewed by members of the scientific committee. Many of the accepted papers had excellent quality, but due to limited space not all of them could be included as full papers in these proceedings. Papers that were rated high by the reviewers are included as long or short papers, others appear as extended abstracts in the last chapter.

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Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Development of Full Field Digital Mammography....Pages 3-10
Initial Operating and Clinical Results of a Full Field Mammography System....Pages 11-18
Design Considerations for a CDZNTE Digital Mammography System....Pages 19-26
High Resolution Mammography Using a Scanned Slit Silicon Strip Detector....Pages 27-30
A CCD Based Digital Detector for Whole-Breast Digital Mammography....Pages 31-34
Evaluation of a Digital Mosaic Mammography Imager....Pages 35-38
Effects of Varying Exit Exposure and Energy Spectrum on the Conspicuity of Calcifications and Masses in Digitally Acquired Mammograms of Cadaveric Breasts....Pages 39-42
Ultra-Small Focal Spot X-Ray Sources for High Resolution Digital Mammography....Pages 43-46
Evaluation of a Digital Spot Mammographic Unit Using a Contrast Detail Phantom....Pages 47-50
Digital Breast Tomosynthesis: Potentially a New Method for Breast Cancer Screening....Pages 51-56
Three-Dimensional Visualization of Breast Cancer....Pages 57-60
Front Matter....Pages 61-61
Detecting the Central Mass of a Spiculated Lesion Using Scale-Orientation Signatures....Pages 63-70
Comparison of Methods for Combining Evidence for Spiculated Lesions....Pages 71-78
A Computer Assisted Diagnostic System for Mass Detection....Pages 79-86
Tumor Detection System for Full-Digital Mammography....Pages 87-94
Combining Single View Features and Asymmetry for Detection of Mass Lesions....Pages 95-102
Comparing Mammogram Pairs for the Detection of Lesions....Pages 103-110
Determining Correspondence Between Views....Pages 111-118
Comparison of Three Mass Detection Methods....Pages 119-126
Classifying Image Features in the Last Screening Mammograms Prior to Detection of a Malignant Mass....Pages 127-134
Front Matter....Pages 61-61
Detection of Spicules on Mammograms Based on a Multistage Pendulum Filter....Pages 135-138
Development of a New Algorithm for Detection of Mammographic Masses....Pages 139-142
Computer-Aided Diagnosis of Digital Mammography and Ultrasound Images of Breast Mass Lesions....Pages 143-147
Front Matter....Pages 149-149
Evaluation of a Neural Network Classifier for Detection of Microcalcifications and Opacities in Digital Mammograms....Pages 151-156
Microcalcifications Detection Using Adaptive Filtering and Gaussianity Tests....Pages 157-164
Detection of Microcalcification Clusters in Digital Mammography Via the Spatial Scan Statistic with Stochastic Scan Partitions....Pages 165-168
Improved Correction for Signal Dependent Noise Applied to Automatic Detection of Microcalcifications....Pages 169-176
Modeling of Digital Mammograms Using Bicubic Spline Functions and Additive Noise....Pages 177-184
Integration of Low-Level Processing to Facilitate Microcalcification Detection....Pages 185-188
Development of a Multi-Feature Cad System for Mammography....Pages 189-196
Automated Detection of Clustered Microcalcifications on Digitized Mammograms....Pages 197-200
Microcalcification Detection System for Full-Digital Mammography....Pages 201-204
Detection of Mammographic Microcalcifications Using a Statistical Model....Pages 205-208
Detection of Subtle Microcalcifications in Digital Mammograms....Pages 209-212
Front Matter....Pages 213-213
Benefits of Computer-Aided Diagnosis (CAD) in Mammographic Diagnosis of Malignant and Benign Clustered Microcalcifications....Pages 215-220
Interactive Quantitative Characterization of Micro-Calcifications on Digitized Film-Screen Mammograms....Pages 221-224
Automated Detection and Classification of Micro-Calcifications in Mammograms Using Artifical Neural Nets....Pages 225-232
Classification of Microcalcifications Using Texture-Based Features....Pages 233-236
Evaluation of a Decision Aid for the Classification of Microcalcifictions....Pages 237-244
Evidential Approach to Improved Microcalcification Characterization....Pages 245-248
Front Matter....Pages 213-213
Comparative Evaluation of Statistical Pattern Recognition Techniques for the Classification of Breast Lesions....Pages 249-252
Detection of Breast Tumor Boundaries Using ISO-Intensity Contours and Dynamic Thresholding....Pages 253-260
Mammographic Region of Interest Database Retrieval and Indexing Engine....Pages 261-264
Front Matter....Pages 265-265
Quantitative Interpretation of Mammograms Based on a Physical Model of the Image Formation Process....Pages 267-274
Estimating Compressed Breast Thickness....Pages 275-278
Sites of Occurrence of Malignancies in Mammograms....Pages 279-282
Simulated Mammography Using Synthetic 3D Breasts....Pages 283-290
Anatomic Segmentation of Mammograms Via Breast Model....Pages 291-294
Multiresolution Wavelet Approach for Separating the Breast Region from the Background in High Resolution Digital Mammography....Pages 295-298
The Fusion of Supervised and Unsupervised Techniques for Segmentation of Abnormal Regions....Pages 299-302
Front Matter....Pages 303-303
Mixture Modeling for Digital Mammogram Display and Analysis....Pages 305-312
Display of High-Resolution Digital Mammograms on CRT Monitors....Pages 313-320
Volume Reconstruction of Clustered Micro-Calcifications in Mammograms....Pages 321-328
Maximum Entropy Improvement of X-Ray Digital Mammograms....Pages 329-336
Differences in Viewing Time for Mammograms Displayed on Film Versus a CRT Monitor....Pages 337-343
Front Matter....Pages 345-345
Prompting in Mammography: How Good Must Prompt Generators Be?....Pages 347-354
Evaluation of a Prompting System Using Interval Cancers....Pages 355-358
Computer-Aided Cancer Detection in the UK Breast Screening Programme....Pages 359-362
Prompting in Practice: How Can We Ensure Radiologists Make Best Use of Computer-Aided Detection Systems in Screening Mammography?....Pages 363-370
Non-Radiologists and CAD Systems in Breast Cancer Screening....Pages 371-374
Front Matter....Pages 345-345
CAD Implementation: Implications from Real Life Visual Search of Screening Cases....Pages 375-382
Mammographic Screening: Sensitivity of General Radiologists....Pages 383-388
Front Matter....Pages 389-389
Initial Clinical Experience with Full Field Digital Mammography....Pages 391-394
Clinical Results with R2 Imagechecker System....Pages 395-400
Prospective Testing of a Clinical Mammography Workstation for CAD: Analysis of the First 10,000 Cases....Pages 401-406
Performance Studies of a Computer-Aided Diagnostic System on Mammograms....Pages 407-410
Direct Magnification Radiography of the Breast in Combination with Computed Radiography: First Clinical Results....Pages 411-414
A Framework for Computer Aided Mammographic Screening for Breast Cancer....Pages 415-418
Computerized Analysis of Digitized Mammograms of Women with Low Breast Cancer Risk and of BRCA1/BRCA2 Gene-Mutation Carriers....Pages 419-422
Comparison of Analog and Digital Spot Magnified Mammography....Pages 423-426
Breast Cancer Screening Results....Pages 427-433
Front Matter....Pages 435-435
Acceptance Testing and Quality Control of Digital Mammography Equipment....Pages 437-444
An Automated Quality Control Program for Whole Breast Digital Image Receptors....Pages 445-448
Management and Lesion Detection Effects of Lossy Image Compression on Digitized Mammograms....Pages 449-456
Current Status of the Digital Database for Screening Mammography....Pages 457-460
Image Standardization for Digital Mammography....Pages 461-464
Automated Detection of Microcalcifications after Lossy Compression of Digital Mammograms....Pages 465-472
Front Matter....Pages 473-473
Automatic Detection of Clustered Microcalcifications Using Morphological Reconstruction....Pages 475-476
Microcalcification Evaluation Based on Shape Parameters....Pages 477-478
An Automatic Non-Deforming Technique for Selective Microcalcifications Enhancement....Pages 479-480
Front Matter....Pages 473-473
The Auto Detection of Cluster Micro-Calcifications in Digital Mammograms Using Texture Energy....Pages 481-482
Precise Segmentation of Calcifications for Reliable Computerized Diagnosis....Pages 483-484
Performance-Evaluation for Automated Detection of Microcalcifications in Mammograms Using Three Different Film-Digitizers....Pages 485-486
A Neural Network Based Method Selecting Gabor Wavelet Filters for the Detection of Microcalcifications....Pages 487-488
Detection and Characterization of Mammographic Masses by Artificial Neural Network....Pages 489-490
Clinical Comparison of Full Breast Storage Phosphor Digital Mammography and Film-Screen Mammography — A Receiver Operating Characteristic Study....Pages 491-492
Computer-Aided Detection (CAD) of Breast-Cancer — Diagnostic Performance of a Further Improved System....Pages 493-494
Comparison of Conventional and Secondarily Digitized Mammograms by ROC — Analysis to Evaluate a Computer System for Digital Routine Mammography....Pages 495-496
3D Reconstruction of Clusters of Mammary Microcalcifications....Pages 497-498
The Calma Project....Pages 499-500
Are There Quantifiable Reasons for a Radiologist’s Preference for an Intensity Inverted Mammogram?....Pages 501-502
The Need to Standardize and Calibrate Databases of Digitized Mammograms....Pages 503-504
Diagnostic Accuracy of Digitized Mammograms Versus Film-Screen Mammograms....Pages 505-506
A Low Cost Computer Assisted Mammography Workstation....Pages 507-508
X-Ray Imaging with a Silicon Microstrip Detector....Pages 509-510
System Considerations for Satellite Transmission of Digitized Mammograms....Pages 511-512
Mobile Breast Care Using DICOM Satellite Telemammography Prompt-Interpretation System....Pages 513-514
Back Matter....Pages 515-519

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Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Development of Full Field Digital Mammography....Pages 3-10
Initial Operating and Clinical Results of a Full Field Mammography System....Pages 11-18
Design Considerations for a CDZNTE Digital Mammography System....Pages 19-26
High Resolution Mammography Using a Scanned Slit Silicon Strip Detector....Pages 27-30
A CCD Based Digital Detector for Whole-Breast Digital Mammography....Pages 31-34
Evaluation of a Digital Mosaic Mammography Imager....Pages 35-38
Effects of Varying Exit Exposure and Energy Spectrum on the Conspicuity of Calcifications and Masses in Digitally Acquired Mammograms of Cadaveric Breasts....Pages 39-42
Ultra-Small Focal Spot X-Ray Sources for High Resolution Digital Mammography....Pages 43-46
Evaluation of a Digital Spot Mammographic Unit Using a Contrast Detail Phantom....Pages 47-50
Digital Breast Tomosynthesis: Potentially a New Method for Breast Cancer Screening....Pages 51-56
Three-Dimensional Visualization of Breast Cancer....Pages 57-60
Front Matter....Pages 61-61
Detecting the Central Mass of a Spiculated Lesion Using Scale-Orientation Signatures....Pages 63-70
Comparison of Methods for Combining Evidence for Spiculated Lesions....Pages 71-78
A Computer Assisted Diagnostic System for Mass Detection....Pages 79-86
Tumor Detection System for Full-Digital Mammography....Pages 87-94
Combining Single View Features and Asymmetry for Detection of Mass Lesions....Pages 95-102
Comparing Mammogram Pairs for the Detection of Lesions....Pages 103-110
Determining Correspondence Between Views....Pages 111-118
Comparison of Three Mass Detection Methods....Pages 119-126
Classifying Image Features in the Last Screening Mammograms Prior to Detection of a Malignant Mass....Pages 127-134
Front Matter....Pages 61-61
Detection of Spicules on Mammograms Based on a Multistage Pendulum Filter....Pages 135-138
Development of a New Algorithm for Detection of Mammographic Masses....Pages 139-142
Computer-Aided Diagnosis of Digital Mammography and Ultrasound Images of Breast Mass Lesions....Pages 143-147
Front Matter....Pages 149-149
Evaluation of a Neural Network Classifier for Detection of Microcalcifications and Opacities in Digital Mammograms....Pages 151-156
Microcalcifications Detection Using Adaptive Filtering and Gaussianity Tests....Pages 157-164
Detection of Microcalcification Clusters in Digital Mammography Via the Spatial Scan Statistic with Stochastic Scan Partitions....Pages 165-168
Improved Correction for Signal Dependent Noise Applied to Automatic Detection of Microcalcifications....Pages 169-176
Modeling of Digital Mammograms Using Bicubic Spline Functions and Additive Noise....Pages 177-184
Integration of Low-Level Processing to Facilitate Microcalcification Detection....Pages 185-188
Development of a Multi-Feature Cad System for Mammography....Pages 189-196
Automated Detection of Clustered Microcalcifications on Digitized Mammograms....Pages 197-200
Microcalcification Detection System for Full-Digital Mammography....Pages 201-204
Detection of Mammographic Microcalcifications Using a Statistical Model....Pages 205-208
Detection of Subtle Microcalcifications in Digital Mammograms....Pages 209-212
Front Matter....Pages 213-213
Benefits of Computer-Aided Diagnosis (CAD) in Mammographic Diagnosis of Malignant and Benign Clustered Microcalcifications....Pages 215-220
Interactive Quantitative Characterization of Micro-Calcifications on Digitized Film-Screen Mammograms....Pages 221-224
Automated Detection and Classification of Micro-Calcifications in Mammograms Using Artifical Neural Nets....Pages 225-232
Classification of Microcalcifications Using Texture-Based Features....Pages 233-236
Evaluation of a Decision Aid for the Classification of Microcalcifictions....Pages 237-244
Evidential Approach to Improved Microcalcification Characterization....Pages 245-248
Front Matter....Pages 213-213
Comparative Evaluation of Statistical Pattern Recognition Techniques for the Classification of Breast Lesions....Pages 249-252
Detection of Breast Tumor Boundaries Using ISO-Intensity Contours and Dynamic Thresholding....Pages 253-260
Mammographic Region of Interest Database Retrieval and Indexing Engine....Pages 261-264
Front Matter....Pages 265-265
Quantitative Interpretation of Mammograms Based on a Physical Model of the Image Formation Process....Pages 267-274
Estimating Compressed Breast Thickness....Pages 275-278
Sites of Occurrence of Malignancies in Mammograms....Pages 279-282
Simulated Mammography Using Synthetic 3D Breasts....Pages 283-290
Anatomic Segmentation of Mammograms Via Breast Model....Pages 291-294
Multiresolution Wavelet Approach for Separating the Breast Region from the Background in High Resolution Digital Mammography....Pages 295-298
The Fusion of Supervised and Unsupervised Techniques for Segmentation of Abnormal Regions....Pages 299-302
Front Matter....Pages 303-303
Mixture Modeling for Digital Mammogram Display and Analysis....Pages 305-312
Display of High-Resolution Digital Mammograms on CRT Monitors....Pages 313-320
Volume Reconstruction of Clustered Micro-Calcifications in Mammograms....Pages 321-328
Maximum Entropy Improvement of X-Ray Digital Mammograms....Pages 329-336
Differences in Viewing Time for Mammograms Displayed on Film Versus a CRT Monitor....Pages 337-343
Front Matter....Pages 345-345
Prompting in Mammography: How Good Must Prompt Generators Be?....Pages 347-354
Evaluation of a Prompting System Using Interval Cancers....Pages 355-358
Computer-Aided Cancer Detection in the UK Breast Screening Programme....Pages 359-362
Prompting in Practice: How Can We Ensure Radiologists Make Best Use of Computer-Aided Detection Systems in Screening Mammography?....Pages 363-370
Non-Radiologists and CAD Systems in Breast Cancer Screening....Pages 371-374
Front Matter....Pages 345-345
CAD Implementation: Implications from Real Life Visual Search of Screening Cases....Pages 375-382
Mammographic Screening: Sensitivity of General Radiologists....Pages 383-388
Front Matter....Pages 389-389
Initial Clinical Experience with Full Field Digital Mammography....Pages 391-394
Clinical Results with R2 Imagechecker System....Pages 395-400
Prospective Testing of a Clinical Mammography Workstation for CAD: Analysis of the First 10,000 Cases....Pages 401-406
Performance Studies of a Computer-Aided Diagnostic System on Mammograms....Pages 407-410
Direct Magnification Radiography of the Breast in Combination with Computed Radiography: First Clinical Results....Pages 411-414
A Framework for Computer Aided Mammographic Screening for Breast Cancer....Pages 415-418
Computerized Analysis of Digitized Mammograms of Women with Low Breast Cancer Risk and of BRCA1/BRCA2 Gene-Mutation Carriers....Pages 419-422
Comparison of Analog and Digital Spot Magnified Mammography....Pages 423-426
Breast Cancer Screening Results....Pages 427-433
Front Matter....Pages 435-435
Acceptance Testing and Quality Control of Digital Mammography Equipment....Pages 437-444
An Automated Quality Control Program for Whole Breast Digital Image Receptors....Pages 445-448
Management and Lesion Detection Effects of Lossy Image Compression on Digitized Mammograms....Pages 449-456
Current Status of the Digital Database for Screening Mammography....Pages 457-460
Image Standardization for Digital Mammography....Pages 461-464
Automated Detection of Microcalcifications after Lossy Compression of Digital Mammograms....Pages 465-472
Front Matter....Pages 473-473
Automatic Detection of Clustered Microcalcifications Using Morphological Reconstruction....Pages 475-476
Microcalcification Evaluation Based on Shape Parameters....Pages 477-478
An Automatic Non-Deforming Technique for Selective Microcalcifications Enhancement....Pages 479-480
Front Matter....Pages 473-473
The Auto Detection of Cluster Micro-Calcifications in Digital Mammograms Using Texture Energy....Pages 481-482
Precise Segmentation of Calcifications for Reliable Computerized Diagnosis....Pages 483-484
Performance-Evaluation for Automated Detection of Microcalcifications in Mammograms Using Three Different Film-Digitizers....Pages 485-486
A Neural Network Based Method Selecting Gabor Wavelet Filters for the Detection of Microcalcifications....Pages 487-488
Detection and Characterization of Mammographic Masses by Artificial Neural Network....Pages 489-490
Clinical Comparison of Full Breast Storage Phosphor Digital Mammography and Film-Screen Mammography — A Receiver Operating Characteristic Study....Pages 491-492
Computer-Aided Detection (CAD) of Breast-Cancer — Diagnostic Performance of a Further Improved System....Pages 493-494
Comparison of Conventional and Secondarily Digitized Mammograms by ROC — Analysis to Evaluate a Computer System for Digital Routine Mammography....Pages 495-496
3D Reconstruction of Clusters of Mammary Microcalcifications....Pages 497-498
The Calma Project....Pages 499-500
Are There Quantifiable Reasons for a Radiologist’s Preference for an Intensity Inverted Mammogram?....Pages 501-502
The Need to Standardize and Calibrate Databases of Digitized Mammograms....Pages 503-504
Diagnostic Accuracy of Digitized Mammograms Versus Film-Screen Mammograms....Pages 505-506
A Low Cost Computer Assisted Mammography Workstation....Pages 507-508
X-Ray Imaging with a Silicon Microstrip Detector....Pages 509-510
System Considerations for Satellite Transmission of Digitized Mammograms....Pages 511-512
Mobile Breast Care Using DICOM Satellite Telemammography Prompt-Interpretation System....Pages 513-514
Back Matter....Pages 515-519
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