Ebook: Male Germline Stem Cells: Developmental and Regenerative Potential

Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.

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Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.

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Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.
Content:
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Pathways to Pluripotency: How Germ Cells Make Stem Cells....Pages 3-24
Pluripotent Stem Cells from the Postnatal Testis: Unlocking the Potential of Spermatogonial Stem Cells....Pages 25-47
Making Germ Cells from Human Embryonic Stem Cells....Pages 49-86
Front Matter....Pages 87-87
Morphometric Description of Spermatogonial Stem Cells and Expansion of Their Clonal Derivatives....Pages 89-105
Spermatogonial Stem Cell Transplantation and Culture....Pages 107-123
The Cluster-Forming Activity Assay: A Short-Term In Vitro Method to Analyze the Activity of Mouse Spermatogonial Stem Cells....Pages 125-134
Molecular Mechanisms Regulating Spermatogonial Stem Cell Fate Decisions....Pages 135-157
Stem Cell Niche System in Mouse Spermatogenesis....Pages 159-175
Front Matter....Pages 177-177
Regenerative Potential of Spermatogenesis after Gonadotoxic Therapies....Pages 179-203
Testicular Xenografting....Pages 205-225
Translating Spermatogonial Stem Cell Transplantation to the Clinic....Pages 227-253
Back Matter....Pages 255-262

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Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.
Content:
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Pathways to Pluripotency: How Germ Cells Make Stem Cells....Pages 3-24
Pluripotent Stem Cells from the Postnatal Testis: Unlocking the Potential of Spermatogonial Stem Cells....Pages 25-47
Making Germ Cells from Human Embryonic Stem Cells....Pages 49-86
Front Matter....Pages 87-87
Morphometric Description of Spermatogonial Stem Cells and Expansion of Their Clonal Derivatives....Pages 89-105
Spermatogonial Stem Cell Transplantation and Culture....Pages 107-123
The Cluster-Forming Activity Assay: A Short-Term In Vitro Method to Analyze the Activity of Mouse Spermatogonial Stem Cells....Pages 125-134
Molecular Mechanisms Regulating Spermatogonial Stem Cell Fate Decisions....Pages 135-157
Stem Cell Niche System in Mouse Spermatogenesis....Pages 159-175
Front Matter....Pages 177-177
Regenerative Potential of Spermatogenesis after Gonadotoxic Therapies....Pages 179-203
Testicular Xenografting....Pages 205-225
Translating Spermatogonial Stem Cell Transplantation to the Clinic....Pages 227-253
Back Matter....Pages 255-262
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