Ebook: Nanoparticles in Biomedical Imaging: Emerging Technologies and Applications

About the Series:

Fundamental Biomedical Technologies features titles in multidisciplinary, technology-driven areas, providing the foundations for breakthrough advances in medicine and biology. The term technology refers, in a vigorously unrestrictive sense, to a broad array of engineering disciplines, the sciences of computation and informatics, mathematical models exploiting and advancing methods of mathematical physics, and the development of novel, experimental discovery devices. Titles in this series are designed and selected to provide high-level visionary input for specialists, while presenting overviews of emerging fields for those in related areas. Volumes in this series aim to provide technologists with the material to gain competent entry into biomedical research and biomedical researchers to understand and embrace novel technological foundations and tools.

About the Series Editor:

Mauro Ferrari is a professor in the Brown Institute of Molecular Medicine, a professor of internal medicine in the division of cardiology, and the chairman of the department of biomedical engineering at the University of Texas Health Science Center in Houston, Texas. He holds concurrent professor appointments at the M.D. Anderson Cancer Center as professor of experimental therapeutics, and at Rice University in bioengineering. Dr. Ferrari is the current President of the Alliance for NanoHealth and he has spearheaded the development of the National Cancer Institute’s nanotechnology programs. Dr. Ferrari is also the founder and Editor-in-Chief of Springer’s archival journal Biomedical Microdevices.

Nanoparticles in Biomedical Imaging

Jeff W.M. Bulte and Michel M.J.J. Modo, Editors

Nanoparticles in Biomedical Imaging focuses on the use of nanoparticles as chemically engineered small entities that now have emerged as widely used diagnostic agents in biomedicine. The book is logically organized by the specific imaging modalities that are currently central in pre-clinical research and clinical routine, including magnetic resonance imaging, radionuclear imaging, ultrasound imaging, computed tomography, and optical imaging. This comprehensive title provides an expert opinion on the latest developments in biomedical imaging using nanoparticles.

Key topics:

Use of superparamagnetic iron oxide nanoparticles in magnetic resonance imaging

Radiolabeled liposomes and their applications in nuclear medicine

Ultrasound bubbles as acoustically reflective medium

Exploiting iodinated nanoparticles with computed tomography

Quantum dots: the bright future of semiconducting optical agents

Nanoparticles in Biomedical Imaging will serve as a useful and valuable resource on the fundamental science of diagnostic nanoparticles in their interactions with biological targets, providing a platform technology for clinical implementation and improved detection of disease.

About the Editors:

Jeff W.M. Bulte is currently a Professor of Radiology and a Professor of Chemical & Biomolecular Engineering at the Johns Hopkins University School of Medicine in Baltimore, USA. He serves as the Director of Cellular Imaging in the JHU Institute for Cell Engineering.

Michel M.J.J. Modo is the Wolfson Lecturer in Stem Cell Imaging at the Centre for the Cellular Basis of Behaviour and the MRC Centre for Neurodegeneration Research at the Institute of Psychiatry, King’s College London.

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About the Series:

Fundamental Biomedical Technologies features titles in multidisciplinary, technology-driven areas, providing the foundations for breakthrough advances in medicine and biology. The term technology refers, in a vigorously unrestrictive sense, to a broad array of engineering disciplines, the sciences of computation and informatics, mathematical models exploiting and advancing methods of mathematical physics, and the development of novel, experimental discovery devices. Titles in this series are designed and selected to provide high-level visionary input for specialists, while presenting overviews of emerging fields for those in related areas. Volumes in this series aim to provide technologists with the material to gain competent entry into biomedical research and biomedical researchers to understand and embrace novel technological foundations and tools.

About the Series Editor:

Mauro Ferrari is a professor in the Brown Institute of Molecular Medicine, a professor of internal medicine in the division of cardiology, and the chairman of the department of biomedical engineering at the University of Texas Health Science Center in Houston, Texas. He holds concurrent professor appointments at the M.D. Anderson Cancer Center as professor of experimental therapeutics, and at Rice University in bioengineering. Dr. Ferrari is the current President of the Alliance for NanoHealth and he has spearheaded the development of the National Cancer Institute’s nanotechnology programs. Dr. Ferrari is also the founder and Editor-in-Chief of Springer’s archival journal Biomedical Microdevices.

Nanoparticles in Biomedical Imaging

Jeff W.M. Bulte and Michel M.J.J. Modo, Editors

Nanoparticles in Biomedical Imaging focuses on the use of nanoparticles as chemically engineered small entities that now have emerged as widely used diagnostic agents in biomedicine. The book is logically organized by the specific imaging modalities that are currently central in pre-clinical research and clinical routine, including magnetic resonance imaging, radionuclear imaging, ultrasound imaging, computed tomography, and optical imaging. This comprehensive title provides an expert opinion on the latest developments in biomedical imaging using nanoparticles.

 

Key topics:

Use of superparamagnetic iron oxide nanoparticles in magnetic resonance imaging

Radiolabeled liposomes and their applications in nuclear medicine

Ultrasound bubbles as acoustically reflective medium

Exploiting iodinated nanoparticles with computed tomography

Quantum dots: the bright future of semiconducting optical agents

 

Nanoparticles in Biomedical Imaging will serve as a useful and valuable resource on the fundamental science of diagnostic nanoparticles in their interactions with biological targets, providing a platform technology for clinical implementation and improved detection of disease.

About the Editors:

Jeff W.M. Bulte is currently a Professor of Radiology and a Professor of Chemical & Biomolecular Engineering at the Johns Hopkins University School of Medicine in Baltimore, USA. He serves as the Director of Cellular Imaging in the JHU Institute for Cell Engineering.

Michel M.J.J. Modo is the Wolfson Lecturer in Stem Cell Imaging at the Centre for the Cellular Basis of Behaviour and the MRC Centre for Neurodegeneration Research at the Institute of Psychiatry, King’s College London.

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About the Series:

Fundamental Biomedical Technologies features titles in multidisciplinary, technology-driven areas, providing the foundations for breakthrough advances in medicine and biology. The term technology refers, in a vigorously unrestrictive sense, to a broad array of engineering disciplines, the sciences of computation and informatics, mathematical models exploiting and advancing methods of mathematical physics, and the development of novel, experimental discovery devices. Titles in this series are designed and selected to provide high-level visionary input for specialists, while presenting overviews of emerging fields for those in related areas. Volumes in this series aim to provide technologists with the material to gain competent entry into biomedical research and biomedical researchers to understand and embrace novel technological foundations and tools.

About the Series Editor:

Mauro Ferrari is a professor in the Brown Institute of Molecular Medicine, a professor of internal medicine in the division of cardiology, and the chairman of the department of biomedical engineering at the University of Texas Health Science Center in Houston, Texas. He holds concurrent professor appointments at the M.D. Anderson Cancer Center as professor of experimental therapeutics, and at Rice University in bioengineering. Dr. Ferrari is the current President of the Alliance for NanoHealth and he has spearheaded the development of the National Cancer Institute’s nanotechnology programs. Dr. Ferrari is also the founder and Editor-in-Chief of Springer’s archival journal Biomedical Microdevices.

Nanoparticles in Biomedical Imaging

Jeff W.M. Bulte and Michel M.J.J. Modo, Editors

Nanoparticles in Biomedical Imaging focuses on the use of nanoparticles as chemically engineered small entities that now have emerged as widely used diagnostic agents in biomedicine. The book is logically organized by the specific imaging modalities that are currently central in pre-clinical research and clinical routine, including magnetic resonance imaging, radionuclear imaging, ultrasound imaging, computed tomography, and optical imaging. This comprehensive title provides an expert opinion on the latest developments in biomedical imaging using nanoparticles.

 

Key topics:

Use of superparamagnetic iron oxide nanoparticles in magnetic resonance imaging

Radiolabeled liposomes and their applications in nuclear medicine

Ultrasound bubbles as acoustically reflective medium

Exploiting iodinated nanoparticles with computed tomography

Quantum dots: the bright future of semiconducting optical agents

 

Nanoparticles in Biomedical Imaging will serve as a useful and valuable resource on the fundamental science of diagnostic nanoparticles in their interactions with biological targets, providing a platform technology for clinical implementation and improved detection of disease.

About the Editors:

Jeff W.M. Bulte is currently a Professor of Radiology and a Professor of Chemical & Biomolecular Engineering at the Johns Hopkins University School of Medicine in Baltimore, USA. He serves as the Director of Cellular Imaging in the JHU Institute for Cell Engineering.

Michel M.J.J. Modo is the Wolfson Lecturer in Stem Cell Imaging at the Centre for the Cellular Basis of Behaviour and the MRC Centre for Neurodegeneration Research at the Institute of Psychiatry, King’s College London.

Content:
Front Matter....Pages I-XVII
Front Matter....Pages 1-1
Introduction: The Emergence of Nanoparticles as Imaging Platform in Biomedicine....Pages 1-5
Front Matter....Pages 7-7
MR Lymphangiography Using Nano-Sized Paramagnetic Contrast Agents with Dendrimer Cores....Pages 9-23
Use of USPIOs for Clinical Lymph Node Imaging....Pages 25-40
Use of SPIOs for Clinical Liver Imaging....Pages 41-61
The Emerging Role of USPIOs for MR Imaging of Atherosclerosis....Pages 63-90
(Super)paramagnetic Nanoparticles: Applications in Noninvasive MR Imaging of Stem Cell Transfer....Pages 91-140
Micron-Sized Iron Oxide Particles (MPIOs) for Cellular Imaging: More Bang for the Buck....Pages 141-161
Molecular MR Imaging with Paramagnetic Perfluorocarbon Nanoparticles....Pages 163-182
Magnetic Nanosensors for Probing Molecular Interactions....Pages 183-197
Magnetoptical Probes....Pages 199-207
Front Matter....Pages 209-209
Use of Radiolabeled Liposomes for Tumor Imaging....Pages 211-236
Use of Radiolabeled Liposomes for Imaging of Infection and Inflammation....Pages 237-251
Sulphur Colloid for Imaging Lymph Nodes and Bone Marrow....Pages 253-285
Front Matter....Pages 287-287
Use of Ultrasound Bubbles in Lymph Node Imaging....Pages 289-310
Use of Ultrasound Microbubbles for Vascular Imaging....Pages 311-325
Targeted Microbubbles: Ultrasound Contrast Agents for Molecular Imaging....Pages 327-341
Use of Acoustically Active Contrast Agents in Imaging of Inflammation and Atherosclerosis....Pages 343-368
Front Matter....Pages 369-369
Iodinated Liposomes as Contrast Agents....Pages 371-410
Front Matter....Pages 411-411
Quantum Dots and Targeted Nanoparticle Probes for In Vivo Tumor Imaging....Pages 413-425
Investigating the Dynamics of Cellular Processes at the Single Molecule Level with Semiconductor Quantum Dots....Pages 427-441
Front Matter....Pages 411-411
Targeting Vascular Epitopes Using Quantum Dots....Pages 443-461
Quantum Dots for Cancer Imaging....Pages 463-485
Bimodal Liposomes and Paramagnetic QD-Micelles for Multimodality Molecular Imaging of Tumor Angiogenesis....Pages 487-512
Back Matter....Pages 513-524

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About the Series:

Fundamental Biomedical Technologies features titles in multidisciplinary, technology-driven areas, providing the foundations for breakthrough advances in medicine and biology. The term technology refers, in a vigorously unrestrictive sense, to a broad array of engineering disciplines, the sciences of computation and informatics, mathematical models exploiting and advancing methods of mathematical physics, and the development of novel, experimental discovery devices. Titles in this series are designed and selected to provide high-level visionary input for specialists, while presenting overviews of emerging fields for those in related areas. Volumes in this series aim to provide technologists with the material to gain competent entry into biomedical research and biomedical researchers to understand and embrace novel technological foundations and tools.

About the Series Editor:

Mauro Ferrari is a professor in the Brown Institute of Molecular Medicine, a professor of internal medicine in the division of cardiology, and the chairman of the department of biomedical engineering at the University of Texas Health Science Center in Houston, Texas. He holds concurrent professor appointments at the M.D. Anderson Cancer Center as professor of experimental therapeutics, and at Rice University in bioengineering. Dr. Ferrari is the current President of the Alliance for NanoHealth and he has spearheaded the development of the National Cancer Institute’s nanotechnology programs. Dr. Ferrari is also the founder and Editor-in-Chief of Springer’s archival journal Biomedical Microdevices.

Nanoparticles in Biomedical Imaging

Jeff W.M. Bulte and Michel M.J.J. Modo, Editors

Nanoparticles in Biomedical Imaging focuses on the use of nanoparticles as chemically engineered small entities that now have emerged as widely used diagnostic agents in biomedicine. The book is logically organized by the specific imaging modalities that are currently central in pre-clinical research and clinical routine, including magnetic resonance imaging, radionuclear imaging, ultrasound imaging, computed tomography, and optical imaging. This comprehensive title provides an expert opinion on the latest developments in biomedical imaging using nanoparticles.

 

Key topics:

Use of superparamagnetic iron oxide nanoparticles in magnetic resonance imaging

Radiolabeled liposomes and their applications in nuclear medicine

Ultrasound bubbles as acoustically reflective medium

Exploiting iodinated nanoparticles with computed tomography

Quantum dots: the bright future of semiconducting optical agents

 

Nanoparticles in Biomedical Imaging will serve as a useful and valuable resource on the fundamental science of diagnostic nanoparticles in their interactions with biological targets, providing a platform technology for clinical implementation and improved detection of disease.

About the Editors:

Jeff W.M. Bulte is currently a Professor of Radiology and a Professor of Chemical & Biomolecular Engineering at the Johns Hopkins University School of Medicine in Baltimore, USA. He serves as the Director of Cellular Imaging in the JHU Institute for Cell Engineering.

Michel M.J.J. Modo is the Wolfson Lecturer in Stem Cell Imaging at the Centre for the Cellular Basis of Behaviour and the MRC Centre for Neurodegeneration Research at the Institute of Psychiatry, King’s College London.

Content:
Front Matter....Pages I-XVII
Front Matter....Pages 1-1
Introduction: The Emergence of Nanoparticles as Imaging Platform in Biomedicine....Pages 1-5
Front Matter....Pages 7-7
MR Lymphangiography Using Nano-Sized Paramagnetic Contrast Agents with Dendrimer Cores....Pages 9-23
Use of USPIOs for Clinical Lymph Node Imaging....Pages 25-40
Use of SPIOs for Clinical Liver Imaging....Pages 41-61
The Emerging Role of USPIOs for MR Imaging of Atherosclerosis....Pages 63-90
(Super)paramagnetic Nanoparticles: Applications in Noninvasive MR Imaging of Stem Cell Transfer....Pages 91-140
Micron-Sized Iron Oxide Particles (MPIOs) for Cellular Imaging: More Bang for the Buck....Pages 141-161
Molecular MR Imaging with Paramagnetic Perfluorocarbon Nanoparticles....Pages 163-182
Magnetic Nanosensors for Probing Molecular Interactions....Pages 183-197
Magnetoptical Probes....Pages 199-207
Front Matter....Pages 209-209
Use of Radiolabeled Liposomes for Tumor Imaging....Pages 211-236
Use of Radiolabeled Liposomes for Imaging of Infection and Inflammation....Pages 237-251
Sulphur Colloid for Imaging Lymph Nodes and Bone Marrow....Pages 253-285
Front Matter....Pages 287-287
Use of Ultrasound Bubbles in Lymph Node Imaging....Pages 289-310
Use of Ultrasound Microbubbles for Vascular Imaging....Pages 311-325
Targeted Microbubbles: Ultrasound Contrast Agents for Molecular Imaging....Pages 327-341
Use of Acoustically Active Contrast Agents in Imaging of Inflammation and Atherosclerosis....Pages 343-368
Front Matter....Pages 369-369
Iodinated Liposomes as Contrast Agents....Pages 371-410
Front Matter....Pages 411-411
Quantum Dots and Targeted Nanoparticle Probes for In Vivo Tumor Imaging....Pages 413-425
Investigating the Dynamics of Cellular Processes at the Single Molecule Level with Semiconductor Quantum Dots....Pages 427-441
Front Matter....Pages 411-411
Targeting Vascular Epitopes Using Quantum Dots....Pages 443-461
Quantum Dots for Cancer Imaging....Pages 463-485
Bimodal Liposomes and Paramagnetic QD-Micelles for Multimodality Molecular Imaging of Tumor Angiogenesis....Pages 487-512
Back Matter....Pages 513-524
....