Ebook: Transplantation of Composite Tissue Allografts
- Tags: Immunology, Surgery, Transplant Surgery, Biomedical Engineering
- Year: 2008
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
This book reviews, updates, and synthesizes the recent accomplishments and ongoing research in the field of composite tissue allotransplantation (CTA). The volume focuses on the immunology, biotechnology, and bioengineering of CTA, as these areas have demonstrated the most growth within the field in the last five years.
The text presents the entire scope of CTA in a comprehensive format. This effort details the state-of-the-art advances in CTA and includes the numerous accomplishments of premier scientists and physicians from around the world engaged in the field. Significant advancements in the evolution of CTA are detailed from the historic legend of "Cosmas and Damian" through the most recent controversial topics of hand and face transplantation.
Transplantation of Composite Tissue Allografts is an ideal and valuable resource for a diverse group of physicians, scientists, researchers, residents, and students. This book will both inform and excite all who are interested in helping patients benefit from transplantation of composite tissue allografts.
About the Editors:
Dr. Charles W. Hewitt is Professor of Surgery at Robert Wood Johnson Medical School and Director of the Division of Surgical Research, University of Medicine and Dentistry of New Jersey/Cooper Health System in Camden, New Jersey.
Dr. W.P. Andrew Lee is Professor of Surgery and Orthopedic Surgery and Chief of the Division of Plastic Surgery at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania.
Dr. Chad R. Gordon is currently serving as Chief Resident in the Department of Surgery at Robert Wood Johnson Medical School/Cooper University Hospital in Camden, New Jersey.
This book reviews, updates, and synthesizes the recent accomplishments and ongoing research in the field of composite tissue allotransplantation (CTA). The volume focuses on the immunology, biotechnology, and bioengineering of CTA, as these areas have demonstrated the most growth within the field in the last five years.
The text presents the entire scope of CTA in a comprehensive format. This effort details the state-of-the-art advances in CTA and includes the numerous accomplishments of premier scientists and physicians from around the world engaged in the field. Significant advancements in the evolution of CTA are detailed from the historic legend of "Cosmas and Damian" through the most recent controversial topics of hand and face transplantation.
Transplantation of Composite Tissue Allografts is an ideal and valuable resource for a diverse group of physicians, scientists, researchers, residents, and students. This book will both inform and excite all who are interested in helping patients benefit from transplantation of composite tissue allografts.
About the Editors:
Dr. Charles W. Hewitt is Professor of Surgery at Robert Wood Johnson Medical School and Director of the Division of Surgical Research, University of Medicine and Dentistry of New Jersey/Cooper Health System in Camden, New Jersey.
Dr. W.P. Andrew Lee is Professor of Surgery and Orthopedic Surgery and Chief of the Division of Plastic Surgery at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania.
Dr. Chad R. Gordon is currently serving as Chief Resident in the Department of Surgery at Robert Wood Johnson Medical School/Cooper University Hospital in Camden, New Jersey.
This book reviews, updates, and synthesizes the recent accomplishments and ongoing research in the field of composite tissue allotransplantation (CTA). The volume focuses on the immunology, biotechnology, and bioengineering of CTA, as these areas have demonstrated the most growth within the field in the last five years.
The text presents the entire scope of CTA in a comprehensive format. This effort details the state-of-the-art advances in CTA and includes the numerous accomplishments of premier scientists and physicians from around the world engaged in the field. Significant advancements in the evolution of CTA are detailed from the historic legend of "Cosmas and Damian" through the most recent controversial topics of hand and face transplantation.
Transplantation of Composite Tissue Allografts is an ideal and valuable resource for a diverse group of physicians, scientists, researchers, residents, and students. This book will both inform and excite all who are interested in helping patients benefit from transplantation of composite tissue allografts.
About the Editors:
Dr. Charles W. Hewitt is Professor of Surgery at Robert Wood Johnson Medical School and Director of the Division of Surgical Research, University of Medicine and Dentistry of New Jersey/Cooper Health System in Camden, New Jersey.
Dr. W.P. Andrew Lee is Professor of Surgery and Orthopedic Surgery and Chief of the Division of Plastic Surgery at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania.
Dr. Chad R. Gordon is currently serving as Chief Resident in the Department of Surgery at Robert Wood Johnson Medical School/Cooper University Hospital in Camden, New Jersey.
Content:
Front Matter....Pages i-xx
The Establishment of Composite Tissue Allotransplantion as a Clinical Reality....Pages 3-12
The Evolution of Composite Tissue Allotransplantation: the Twentieth Century Realization of “Cosmas and Damian”....Pages 13-25
The Impact of the Discovery of Cyclosporine on Transplantation of Composite Tissue Allografts....Pages 26-35
The First Limb Transplants with Cyclosporine....Pages 36-39
Translational Research in Composite Tissue Allotransplantation....Pages 43-54
Relative Antigenicity of Allograft Components and Differential Rejection....Pages 55-69
On the Road to Tolerance Induction in Composite Tissue Allotransplantation....Pages 70-87
Donor-Specific Tolerance....Pages 89-104
Immune Tolerance Induction: Basic Concepts for Composite Tissue Allotransplantation....Pages 105-117
Allograft Survival with Calcineurin Inhibitors....Pages 121-149
Long-Term Prevention of Rejection and Combination Drug Therapy....Pages 150-162
Locoregional Immunosuppression in Composite Tissue Allografting....Pages 164-171
New Approaches to Antibody Therapy....Pages 172-190
World Experience of Hand Transplantation-Independent Assessment....Pages 193-208
Hand Transplantation: Lyon Experience....Pages 209-214
Hand Transplantation: The Louisville Experience....Pages 215-233
Hand Transplantation: The Innsbruck Experience....Pages 234-250
Vascularized Bone Marrow Transplantation....Pages 253-271
Vascularized Bone Marrow Transplantation: Pathology of Composite Tissue Transplantation-Induced Graft-Versus-Host-Disease....Pages 272-277
Immune Cell Redistribution After Vascularized Bone Marrow Transplantation....Pages 278-289
Vascularized Knee Transplantation....Pages 293-306
Tracheal Transplantation....Pages 307-329
Laryngeal Transplantation....Pages 330-343
Face Transplantation....Pages 344-354
The Role of Allografts in Lower Extremity Reconstruction....Pages 355-366
Skin Allografts in Scalp Reconstruction....Pages 367-373
Abdominal Wall Transplantation....Pages 374-381
Peripheral Nerve Allotransplantation....Pages 382-406
Live-Donor Nerve Transplantation....Pages 407-426
Ethical and Policy Concerns of Hand/Face Transplantation....Pages 429-442
Ethical Debate on Human Face Transplantation....Pages 443-451
Psychosocial Issues in Composite Tissue Allotransplantation....Pages 452-459
Composite Tissue Transplantation in the Twenty-First Century....Pages 460-466
Back Matter....Pages 467-483
This book reviews, updates, and synthesizes the recent accomplishments and ongoing research in the field of composite tissue allotransplantation (CTA). The volume focuses on the immunology, biotechnology, and bioengineering of CTA, as these areas have demonstrated the most growth within the field in the last five years.
The text presents the entire scope of CTA in a comprehensive format. This effort details the state-of-the-art advances in CTA and includes the numerous accomplishments of premier scientists and physicians from around the world engaged in the field. Significant advancements in the evolution of CTA are detailed from the historic legend of "Cosmas and Damian" through the most recent controversial topics of hand and face transplantation.
Transplantation of Composite Tissue Allografts is an ideal and valuable resource for a diverse group of physicians, scientists, researchers, residents, and students. This book will both inform and excite all who are interested in helping patients benefit from transplantation of composite tissue allografts.
About the Editors:
Dr. Charles W. Hewitt is Professor of Surgery at Robert Wood Johnson Medical School and Director of the Division of Surgical Research, University of Medicine and Dentistry of New Jersey/Cooper Health System in Camden, New Jersey.
Dr. W.P. Andrew Lee is Professor of Surgery and Orthopedic Surgery and Chief of the Division of Plastic Surgery at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania.
Dr. Chad R. Gordon is currently serving as Chief Resident in the Department of Surgery at Robert Wood Johnson Medical School/Cooper University Hospital in Camden, New Jersey.
Content:
Front Matter....Pages i-xx
The Establishment of Composite Tissue Allotransplantion as a Clinical Reality....Pages 3-12
The Evolution of Composite Tissue Allotransplantation: the Twentieth Century Realization of “Cosmas and Damian”....Pages 13-25
The Impact of the Discovery of Cyclosporine on Transplantation of Composite Tissue Allografts....Pages 26-35
The First Limb Transplants with Cyclosporine....Pages 36-39
Translational Research in Composite Tissue Allotransplantation....Pages 43-54
Relative Antigenicity of Allograft Components and Differential Rejection....Pages 55-69
On the Road to Tolerance Induction in Composite Tissue Allotransplantation....Pages 70-87
Donor-Specific Tolerance....Pages 89-104
Immune Tolerance Induction: Basic Concepts for Composite Tissue Allotransplantation....Pages 105-117
Allograft Survival with Calcineurin Inhibitors....Pages 121-149
Long-Term Prevention of Rejection and Combination Drug Therapy....Pages 150-162
Locoregional Immunosuppression in Composite Tissue Allografting....Pages 164-171
New Approaches to Antibody Therapy....Pages 172-190
World Experience of Hand Transplantation-Independent Assessment....Pages 193-208
Hand Transplantation: Lyon Experience....Pages 209-214
Hand Transplantation: The Louisville Experience....Pages 215-233
Hand Transplantation: The Innsbruck Experience....Pages 234-250
Vascularized Bone Marrow Transplantation....Pages 253-271
Vascularized Bone Marrow Transplantation: Pathology of Composite Tissue Transplantation-Induced Graft-Versus-Host-Disease....Pages 272-277
Immune Cell Redistribution After Vascularized Bone Marrow Transplantation....Pages 278-289
Vascularized Knee Transplantation....Pages 293-306
Tracheal Transplantation....Pages 307-329
Laryngeal Transplantation....Pages 330-343
Face Transplantation....Pages 344-354
The Role of Allografts in Lower Extremity Reconstruction....Pages 355-366
Skin Allografts in Scalp Reconstruction....Pages 367-373
Abdominal Wall Transplantation....Pages 374-381
Peripheral Nerve Allotransplantation....Pages 382-406
Live-Donor Nerve Transplantation....Pages 407-426
Ethical and Policy Concerns of Hand/Face Transplantation....Pages 429-442
Ethical Debate on Human Face Transplantation....Pages 443-451
Psychosocial Issues in Composite Tissue Allotransplantation....Pages 452-459
Composite Tissue Transplantation in the Twenty-First Century....Pages 460-466
Back Matter....Pages 467-483
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