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Artificial sight is a frontier area of modern ophthalmology combining the multidisciplinary skills of surgical ophthalmology, biomedical engineering, biological physics, and psychophysical testing. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The goal of Artificial Sight is to summarize the state-of-the-art research in this exciting area, and to describe some of the current approaches and initiatives that may help patients in a clinical setting.

The Editors are active researchers in the fields of artificial sight, biomedical engineering and biological physics. They have received numerous professional awards and recognition for their work. The artificial sight team at the Doheny Eye Institute, led by Dr. Mark Humayun, is a world leader in this area of biomedical engineering and clinical research.

Key Features

  • Introduces and assesses the state of the art for a broad audience of biomedical engineers, biophysicists, and clinical researchers
  • Describes advances in microelectronics, microfabrication, surgical implantation, and psychophysical testing of visual prostheses
  • Outlines the promise of artificial sight and the challenges that must be met




Artificial sight is a frontier area of modern ophthalmology combining the multidisciplinary skills of surgical ophthalmology, biomedical engineering, biological physics, and psychophysical testing. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The goal of Artificial Sight is to summarize the state-of-the-art research in this exciting area, and to describe some of the current approaches and initiatives that may help patients in a clinical setting.

The Editors are active researchers in the fields of artificial sight, biomedical engineering and biological physics. They have received numerous professional awards and recognition for their work. The artificial sight team at the Doheny Eye Institute, led by Dr. Mark Humayun, is a world leader in this area of biomedical engineering and clinical research.

Key Features

  • Introduces and assesses the state of the art for a broad audience of biomedical engineers, biophysicists, and clinical researchers
  • Describes advances in microelectronics, microfabrication, surgical implantation, and psychophysical testing of visual prostheses
  • Outlines the promise of artificial sight and the challenges that must be met



Artificial sight is a frontier area of modern ophthalmology combining the multidisciplinary skills of surgical ophthalmology, biomedical engineering, biological physics, and psychophysical testing. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The goal of Artificial Sight is to summarize the state-of-the-art research in this exciting area, and to describe some of the current approaches and initiatives that may help patients in a clinical setting.

The Editors are active researchers in the fields of artificial sight, biomedical engineering and biological physics. They have received numerous professional awards and recognition for their work. The artificial sight team at the Doheny Eye Institute, led by Dr. Mark Humayun, is a world leader in this area of biomedical engineering and clinical research.

Key Features

  • Introduces and assesses the state of the art for a broad audience of biomedical engineers, biophysicists, and clinical researchers
  • Describes advances in microelectronics, microfabrication, surgical implantation, and psychophysical testing of visual prostheses
  • Outlines the promise of artificial sight and the challenges that must be met

Content:
Front Matter....Pages I-XXIII
Biological Considerations for an Intraocular Retinal Prosthesis....Pages 1-29
Artificial Vision: Vision of a Newcomer....Pages 31-45
The Effects of Visual Deprivation: Implications for Sensory Prostheses....Pages 47-70
Prosthetic Vision Simulation in Fully and Partially Sighted Individuals....Pages 71-90
Testing Visual Functions in Patients with Visual Prostheses....Pages 91-110
The IMI Retinal Implant System....Pages 111-128
Challenges in Realizing a Chronic High-Resolution Retinal Prosthesis....Pages 129-149
Large-scale Integration–Based Stimulus Electrodes for Retinal Prosthesis....Pages 151-168
Development of a Wireless High-Frequency Microarray Implant for Retinal Stimulation....Pages 169-186
Visual Prosthesis Based on Optic Nerve Stimulation with Penetrating Electrode Array....Pages 187-207
Dynamic Interactions of Retinal Prosthesis Electrodes with Neural Tissue and Materials Science in Electrode Design....Pages 209-226
In Vitro Determination of Stimulus-Induced pH Changes in Visual Prostheses....Pages 227-241
Electrochemical Characterization of Implantable High Aspect Ratio Nanoparticle Platinum Electrodes for Neural Stimulations....Pages 243-254
High-Resolution Opto-Electronic Retinal Prosthesis: Physical Limitations and Design....Pages 255-277
Computational Modeling of Electromagnetic and Thermal Effects for a Dual-Unit Retinal Prosthesis: Inductive Telemetry, Temperature Increase, and Current Densities in the Retina....Pages 279-305
Microstimulation with Chronically Implanted Intracortical Electrodes....Pages 307-323
A Tissue Change After Suprachoroidal-Transretinal Stimulation with High Electrical Current in Rabbits....Pages 325-332
Electrical Stimulation of Mammalian Retinal Ganglion Cells Using Dense Arrays of Small-Diameter Electrodes....Pages 333-345
A Mechanism for Generating Precise Temporal Patterns of Activity Using Prosthetic Stimulation....Pages 347-354
Electrophysiology of Natural and Artificial Vision....Pages 355-380
Back Matter....Pages 381-394


Artificial sight is a frontier area of modern ophthalmology combining the multidisciplinary skills of surgical ophthalmology, biomedical engineering, biological physics, and psychophysical testing. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The goal of Artificial Sight is to summarize the state-of-the-art research in this exciting area, and to describe some of the current approaches and initiatives that may help patients in a clinical setting.

The Editors are active researchers in the fields of artificial sight, biomedical engineering and biological physics. They have received numerous professional awards and recognition for their work. The artificial sight team at the Doheny Eye Institute, led by Dr. Mark Humayun, is a world leader in this area of biomedical engineering and clinical research.

Key Features

  • Introduces and assesses the state of the art for a broad audience of biomedical engineers, biophysicists, and clinical researchers
  • Describes advances in microelectronics, microfabrication, surgical implantation, and psychophysical testing of visual prostheses
  • Outlines the promise of artificial sight and the challenges that must be met

Content:
Front Matter....Pages I-XXIII
Biological Considerations for an Intraocular Retinal Prosthesis....Pages 1-29
Artificial Vision: Vision of a Newcomer....Pages 31-45
The Effects of Visual Deprivation: Implications for Sensory Prostheses....Pages 47-70
Prosthetic Vision Simulation in Fully and Partially Sighted Individuals....Pages 71-90
Testing Visual Functions in Patients with Visual Prostheses....Pages 91-110
The IMI Retinal Implant System....Pages 111-128
Challenges in Realizing a Chronic High-Resolution Retinal Prosthesis....Pages 129-149
Large-scale Integration–Based Stimulus Electrodes for Retinal Prosthesis....Pages 151-168
Development of a Wireless High-Frequency Microarray Implant for Retinal Stimulation....Pages 169-186
Visual Prosthesis Based on Optic Nerve Stimulation with Penetrating Electrode Array....Pages 187-207
Dynamic Interactions of Retinal Prosthesis Electrodes with Neural Tissue and Materials Science in Electrode Design....Pages 209-226
In Vitro Determination of Stimulus-Induced pH Changes in Visual Prostheses....Pages 227-241
Electrochemical Characterization of Implantable High Aspect Ratio Nanoparticle Platinum Electrodes for Neural Stimulations....Pages 243-254
High-Resolution Opto-Electronic Retinal Prosthesis: Physical Limitations and Design....Pages 255-277
Computational Modeling of Electromagnetic and Thermal Effects for a Dual-Unit Retinal Prosthesis: Inductive Telemetry, Temperature Increase, and Current Densities in the Retina....Pages 279-305
Microstimulation with Chronically Implanted Intracortical Electrodes....Pages 307-323
A Tissue Change After Suprachoroidal-Transretinal Stimulation with High Electrical Current in Rabbits....Pages 325-332
Electrical Stimulation of Mammalian Retinal Ganglion Cells Using Dense Arrays of Small-Diameter Electrodes....Pages 333-345
A Mechanism for Generating Precise Temporal Patterns of Activity Using Prosthetic Stimulation....Pages 347-354
Electrophysiology of Natural and Artificial Vision....Pages 355-380
Back Matter....Pages 381-394
....
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