Ebook: Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials: Techniques and Applications
- Tags: Imaging / Radiology, Orthopedics, Biomedical Engineering, Physiotherapy, Endocrinology, Metabolic Diseases
- Year: 2007
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
This book provides a perspective on the current status of bioimaging technologies developed to assess the quality of musculoskeletal tissue with an emphasis on bone and cartilage. It offers evaluations of scaffold biomaterials developed for enhancing the repair of musculoskeletal tissues. These bioimaging techniques include micro-CT, nano-CT, pQCT/QCT, MRI, and ultrasound, which provide not only 2-D and 3-D images of the related organs or tissues, but also quantifications of the relevant parameters. The advance bioimaging technologies developed for the above applications are also extended by incorporating imaging contrast-enhancement materials. Thus, this book will provide a unique platform for multidisciplinary collaborations in education and joint R&D among various professions, including biomedical engineering, biomaterials, and basic and clinical medicine.
This book provides a perspective on the current status of bioimaging technologies developed to assess the quality of musculoskeletal tissue with an emphasis on bone and cartilage. It offers evaluations of scaffold biomaterials developed for enhancing the repair of musculoskeletal tissues. These bioimaging techniques include micro-CT, nano-CT, pQCT/QCT, MRI, and ultrasound, which provide not only 2-D and 3-D images of the related organs or tissues, but also quantifications of the relevant parameters. The advance bioimaging technologies developed for the above applications are also extended by incorporating imaging contrast-enhancement materials. Thus, this book will provide a unique platform for multidisciplinary collaborations in education and joint R&D among various professions, including biomedical engineering, biomaterials, and basic and clinical medicine.
This book provides a perspective on the current status of bioimaging technologies developed to assess the quality of musculoskeletal tissue with an emphasis on bone and cartilage. It offers evaluations of scaffold biomaterials developed for enhancing the repair of musculoskeletal tissues. These bioimaging techniques include micro-CT, nano-CT, pQCT/QCT, MRI, and ultrasound, which provide not only 2-D and 3-D images of the related organs or tissues, but also quantifications of the relevant parameters. The advance bioimaging technologies developed for the above applications are also extended by incorporating imaging contrast-enhancement materials. Thus, this book will provide a unique platform for multidisciplinary collaborations in education and joint R&D among various professions, including biomedical engineering, biomaterials, and basic and clinical medicine.
Content:
Front Matter....Pages I-XV
Front Matter....Pages 1-1
Perspectives on Advances in Bone Imaging for Osteoporosis....Pages 5-26
Bone Structure and Biomechanical Analyses Using Imaging and Simulation Technology....Pages 27-50
Imaging Technologies for Orthopaedic Visualization and Simulation....Pages 51-64
In-Vivo Bone Mineral Density and Structures in Humans: From Isotom Over Densiscan to Xtreme-CT....Pages 65-78
Calibration of Micro-CT Data for Quantifying Bone Mineral and Biomaterial Density and Microarchitecture....Pages 79-84
Repositioning of the Region of Interest in the Radius of the Growing Child in Follow-up Measurements by pQCT....Pages 85-102
Non-invasive Bone Quality Assessment Using Quantitative Ultrasound Imaging and Acoustic Parameters....Pages 103-131
Cortical Bone Mineral Status Evaluated by pQCT, Quantitative Backscattered Electron Imaging and Polarized Light Microscopy....Pages 135-161
High-Fidelity Histologic Three-Dimensional Analysis of Bone and Cartilage....Pages 163-171
Application of Laser Scanning Confocal Microscopy in Musculoskeletal Research....Pages 173-189
Fiber-optic Nano-biosensors and Near-Field Scanning Optical Microscopy for Biological Imaging....Pages 191-203
Changes of Biological Function of Bone Cells and Effect of Anti-osteoporosis Agents on Bone Cells....Pages 205-222
Bone Histomorphometry in Various Metabolic Bone Diseases Studied by Bone Biopsy in China....Pages 223-225
Cell Traction Force Microscopy....Pages 227-235
Contrast-Enhanced Micro-CT Imaging of Soft Tissues....Pages 239-256
Materials Selection and Scaffold Fabrication for Tissue Engineering in Orthopaedics....Pages 259-288
Quantification of Porosity, Connectivity and Material Density of Calcium Phosphate Ceramic Implants Using Micro-Computed Tomography....Pages 289-305
Bone Densitometries in Assessing Bone Mineral and Structural Profiles in Patients with Adolescent Idiopathic Scoliosis....Pages 307-322
Application of Nano-CT and High-Resolution Micro-CT to Study Bone Quality and Ultrastructure, Scaffold Biomaterials and Vascular Networks....Pages 323-331
Bio-imaging Technologies in Studying Bone-Biomaterial Interface: Applications in Experimental Spinal Fusion Model....Pages 333-351
Front Matter....Pages 1-1
Assessment of Bone, Cartilage, Tendon and Bone Cells by Confocal Laser Scanning Microscopy....Pages 353-367
Front Matter....Pages 369-369
TEM Study of Bone and Scaffold Materials....Pages 373-392
Material and Structural Basis of Bone Fragility: A Rational Approach to Therapy....Pages 393-398
Application of Micro-CT and MRI in Clinical and Preclinical Studies of Osteoporosis and Related Disorders....Pages 399-415
CT-Based Microstructure Analysis for Assessment of Bone Fragility....Pages 417-429
Discrimination of Contributing Factors to Bone Fragility Using vQCT In Vivo....Pages 431-449
Osteoporosis Research with the vivaCT40....Pages 451-462
Mechanical Properties of Vertebral Trabeculae with Ageing Evaluated with Micro-CT....Pages 463-473
MRI Evaluation of Osteoporosis....Pages 475-484
Multiple Bio-imaging Modalities in Evaluation of Epimedium-Derived Phytoestrogenic Fraction for Prevention of Postmenopausal Osteoporosis....Pages 485-504
Areal and Volumetric Bone Densitometry in Evaluation of Tai Chi Chuan Exercise for Prevention of Postmenopausal Osteoporosis....Pages 505-515
Enhancement of Osteoporotic Bone Using Injectable Hydroxyapatite in OVX Goats Evaluated by Multi-imaging Modalities....Pages 517-527
Quality of Healing Compared Between Osteoporotic Fracture and Normal Traumatic Fracture....Pages 531-541
Monitoring Fracture Healing Using Digital Radiographies....Pages 543-552
Fracture Callus Under Anti-resorptive Agent Treatment Evaluated by pQCT....Pages 553-566
Volumetric Measurement of Osteonecrotic Femoral Head Using Computerized MRI and Prediction For Its Mechanical Properties....Pages 569-577
Biomedical Engineering in Surgical Repair of Osteonecrosis: the Role of Imaging Technology....Pages 579-591
Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis....Pages 593-611
Nanomechanics of Bone and Bioactive Bone-Cement Interfaces....Pages 613-625
Subchondral Bone Microarchitecture Changes in Animal Models of Arthritis....Pages 629-640
Front Matter....Pages 369-369
Microarchitectural Adaptations of Primary Osteoarthrotic Subchondral Bone....Pages 641-655
Ultrasonic Characterization of Dynamic Depth-Dependent Biomechanical Properties of Articular Cartilage....Pages 657-671
Mechanical Property of Trabecular Bone of the Femoral Heads from Osteoarthritis and Osteoporosis Patients....Pages 673-690
Back Matter....Pages 691-700
This book provides a perspective on the current status of bioimaging technologies developed to assess the quality of musculoskeletal tissue with an emphasis on bone and cartilage. It offers evaluations of scaffold biomaterials developed for enhancing the repair of musculoskeletal tissues. These bioimaging techniques include micro-CT, nano-CT, pQCT/QCT, MRI, and ultrasound, which provide not only 2-D and 3-D images of the related organs or tissues, but also quantifications of the relevant parameters. The advance bioimaging technologies developed for the above applications are also extended by incorporating imaging contrast-enhancement materials. Thus, this book will provide a unique platform for multidisciplinary collaborations in education and joint R&D among various professions, including biomedical engineering, biomaterials, and basic and clinical medicine.
Content:
Front Matter....Pages I-XV
Front Matter....Pages 1-1
Perspectives on Advances in Bone Imaging for Osteoporosis....Pages 5-26
Bone Structure and Biomechanical Analyses Using Imaging and Simulation Technology....Pages 27-50
Imaging Technologies for Orthopaedic Visualization and Simulation....Pages 51-64
In-Vivo Bone Mineral Density and Structures in Humans: From Isotom Over Densiscan to Xtreme-CT....Pages 65-78
Calibration of Micro-CT Data for Quantifying Bone Mineral and Biomaterial Density and Microarchitecture....Pages 79-84
Repositioning of the Region of Interest in the Radius of the Growing Child in Follow-up Measurements by pQCT....Pages 85-102
Non-invasive Bone Quality Assessment Using Quantitative Ultrasound Imaging and Acoustic Parameters....Pages 103-131
Cortical Bone Mineral Status Evaluated by pQCT, Quantitative Backscattered Electron Imaging and Polarized Light Microscopy....Pages 135-161
High-Fidelity Histologic Three-Dimensional Analysis of Bone and Cartilage....Pages 163-171
Application of Laser Scanning Confocal Microscopy in Musculoskeletal Research....Pages 173-189
Fiber-optic Nano-biosensors and Near-Field Scanning Optical Microscopy for Biological Imaging....Pages 191-203
Changes of Biological Function of Bone Cells and Effect of Anti-osteoporosis Agents on Bone Cells....Pages 205-222
Bone Histomorphometry in Various Metabolic Bone Diseases Studied by Bone Biopsy in China....Pages 223-225
Cell Traction Force Microscopy....Pages 227-235
Contrast-Enhanced Micro-CT Imaging of Soft Tissues....Pages 239-256
Materials Selection and Scaffold Fabrication for Tissue Engineering in Orthopaedics....Pages 259-288
Quantification of Porosity, Connectivity and Material Density of Calcium Phosphate Ceramic Implants Using Micro-Computed Tomography....Pages 289-305
Bone Densitometries in Assessing Bone Mineral and Structural Profiles in Patients with Adolescent Idiopathic Scoliosis....Pages 307-322
Application of Nano-CT and High-Resolution Micro-CT to Study Bone Quality and Ultrastructure, Scaffold Biomaterials and Vascular Networks....Pages 323-331
Bio-imaging Technologies in Studying Bone-Biomaterial Interface: Applications in Experimental Spinal Fusion Model....Pages 333-351
Front Matter....Pages 1-1
Assessment of Bone, Cartilage, Tendon and Bone Cells by Confocal Laser Scanning Microscopy....Pages 353-367
Front Matter....Pages 369-369
TEM Study of Bone and Scaffold Materials....Pages 373-392
Material and Structural Basis of Bone Fragility: A Rational Approach to Therapy....Pages 393-398
Application of Micro-CT and MRI in Clinical and Preclinical Studies of Osteoporosis and Related Disorders....Pages 399-415
CT-Based Microstructure Analysis for Assessment of Bone Fragility....Pages 417-429
Discrimination of Contributing Factors to Bone Fragility Using vQCT In Vivo....Pages 431-449
Osteoporosis Research with the vivaCT40....Pages 451-462
Mechanical Properties of Vertebral Trabeculae with Ageing Evaluated with Micro-CT....Pages 463-473
MRI Evaluation of Osteoporosis....Pages 475-484
Multiple Bio-imaging Modalities in Evaluation of Epimedium-Derived Phytoestrogenic Fraction for Prevention of Postmenopausal Osteoporosis....Pages 485-504
Areal and Volumetric Bone Densitometry in Evaluation of Tai Chi Chuan Exercise for Prevention of Postmenopausal Osteoporosis....Pages 505-515
Enhancement of Osteoporotic Bone Using Injectable Hydroxyapatite in OVX Goats Evaluated by Multi-imaging Modalities....Pages 517-527
Quality of Healing Compared Between Osteoporotic Fracture and Normal Traumatic Fracture....Pages 531-541
Monitoring Fracture Healing Using Digital Radiographies....Pages 543-552
Fracture Callus Under Anti-resorptive Agent Treatment Evaluated by pQCT....Pages 553-566
Volumetric Measurement of Osteonecrotic Femoral Head Using Computerized MRI and Prediction For Its Mechanical Properties....Pages 569-577
Biomedical Engineering in Surgical Repair of Osteonecrosis: the Role of Imaging Technology....Pages 579-591
Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis....Pages 593-611
Nanomechanics of Bone and Bioactive Bone-Cement Interfaces....Pages 613-625
Subchondral Bone Microarchitecture Changes in Animal Models of Arthritis....Pages 629-640
Front Matter....Pages 369-369
Microarchitectural Adaptations of Primary Osteoarthrotic Subchondral Bone....Pages 641-655
Ultrasonic Characterization of Dynamic Depth-Dependent Biomechanical Properties of Articular Cartilage....Pages 657-671
Mechanical Property of Trabecular Bone of the Femoral Heads from Osteoarthritis and Osteoporosis Patients....Pages 673-690
Back Matter....Pages 691-700
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