Ebook: Mechanics of Biological Tissue

The mechanics of biological tissues is a multidisciplinary and rapidly expanding area of research. This book highlights some important research directions that combine mechanical sciences with exciting new developments in biology.

It includes state-of-the-art articles on:

• Tissue growth and remodelling – general continuum theories of growth, remodelling and adaptation, with specific applications to arterial, tendon and cartilage growth and to bone healing.
• Micromechanics, cells and matrix – measurements of the mechanical properties of cells, engineering of cell systems, constitutive and computational modelling of cells and cell-substrate interactions, and the transition from microscopic modelling to its macroscopic consequences.
• Arteries in health and disease – analysis of residual stress and its development, modelling the constitutive properties of arterial walls, computational analysis of the effect of stenting on the arterial wall, studies of collagen fibre distributions in saccular aneurysms and the interaction between blood flow and aneurysm development.
• Biological tissues – the musculo-skeletal system, heart valves, ligaments, intervertebral discs, the uterus and vocal fold tissues, with experimental, modelling and computational perspectives.
• Image-based analysis – illustration of imaging techniques that have great potential for the analysis of tissue properties and pathologies and for guiding the design of engineered tissue constructs.

This collection of papers should be of interest to theoretical, computational and experimental researchers and doctoral students in the area of biomechanics and in related areas of engineering, biology and medicine.

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The mechanics of biological tissues is a multidisciplinary and rapidly expanding area of research. This book highlights some important research directions that combine mechanical sciences with exciting new developments in biology.

 

It includes state-of-the-art articles on:

• Tissue growth and remodelling – general continuum theories of growth, remodelling and adaptation, with specific applications to arterial, tendon and cartilage growth and to bone healing.
• Micromechanics, cells and matrix – measurements of the mechanical properties of cells, engineering of cell systems, constitutive and computational modelling of cells and cell-substrate interactions, and the transition from microscopic modelling to its macroscopic consequences.
• Arteries in health and disease – analysis of residual stress and its development, modelling the constitutive properties of arterial walls, computational analysis of the effect of stenting on the arterial wall, studies of collagen fibre distributions in saccular aneurysms and the interaction between blood flow and aneurysm development.
• Biological tissues – the musculo-skeletal system, heart valves, ligaments, intervertebral discs, the uterus and vocal fold tissues, with experimental, modelling and computational perspectives.
• Image-based analysis – illustration of imaging techniques that have great potential for the analysis of tissue properties and pathologies and for guiding the design of engineered tissue constructs.

 

This collection of papers should be of interest to theoretical, computational and experimental researchers and doctoral students in the area of biomechanics and in related areas of engineering, biology and medicine.

---

The mechanics of biological tissues is a multidisciplinary and rapidly expanding area of research. This book highlights some important research directions that combine mechanical sciences with exciting new developments in biology.

 

It includes state-of-the-art articles on:

• Tissue growth and remodelling – general continuum theories of growth, remodelling and adaptation, with specific applications to arterial, tendon and cartilage growth and to bone healing.
• Micromechanics, cells and matrix – measurements of the mechanical properties of cells, engineering of cell systems, constitutive and computational modelling of cells and cell-substrate interactions, and the transition from microscopic modelling to its macroscopic consequences.
• Arteries in health and disease – analysis of residual stress and its development, modelling the constitutive properties of arterial walls, computational analysis of the effect of stenting on the arterial wall, studies of collagen fibre distributions in saccular aneurysms and the interaction between blood flow and aneurysm development.
• Biological tissues – the musculo-skeletal system, heart valves, ligaments, intervertebral discs, the uterus and vocal fold tissues, with experimental, modelling and computational perspectives.
• Image-based analysis – illustration of imaging techniques that have great potential for the analysis of tissue properties and pathologies and for guiding the design of engineered tissue constructs.

 

This collection of papers should be of interest to theoretical, computational and experimental researchers and doctoral students in the area of biomechanics and in related areas of engineering, biology and medicine.

Content:
Front Matter....Pages I-XII
Front Matter....Pages 1-1
Towards a Theory of Vascular Growth and Remodeling....Pages 3-15
Complementary Roles of Theoretical Modeling and Computer-controlled Experimentation in Vascular Growth and Remodeling....Pages 17-28
On the Modeling of Growth and Adaptation....Pages 29-46
Growth in Soft Biological Tissue and Residual Stress Development....Pages 47-62
Characterization and Modeling of Growth and Remodeling in Tendon and Soft Tissue Constructs....Pages 63-75
Modeling and Simulation of Remodeling in Soft Biological Tissues....Pages 77-89
Anisotropic Remodelling of Biological Tissues....Pages 91-104
A Mechanobiological Formulation of Bone Healing....Pages 105-118
Continuum Models of Growth with Emphasis on Articular Cartilage....Pages 119-133
Front Matter....Pages 135-135
Tensile Properties and Local Stiffness of Cells....Pages 137-152
Microfluid-dynamics in Three-dimensional Engineered Cell Systems....Pages 153-164
Nonlinear Constitutive Models for Cochlear Outer Hair Cells....Pages 165-176
Prediction of Changes in Cell-substrate Contact under Cyclic Substrate Deformation Using Cohesive Zone Modelling....Pages 177-187
Micromechanics and Macromechanics of the Tensile Deformation of Nacre....Pages 189-203
Front Matter....Pages 205-205
Mechanical Properties of Atherosclerotic Tissues....Pages 207-223
Towards a Computational Methodology for Optimizing Angioplasty Treatments with Stenting....Pages 225-240
Computational Modeling of Stented Arteries: Considerations for Evolving Stent Designs....Pages 241-253
Simulation of In-stent Restenosis for the Design of Cardiovascular Stents....Pages 255-267
Material Property Alterations with Early Atheroma in an Animal Model....Pages 269-282
Microscopic Analysis of Residual Stress and Strain in the Aortic Media Considering Anisotropy of Smooth Muscle Layer....Pages 283-294
Front Matter....Pages 205-205
Parameter Identification in Arteries Using Constraints....Pages 295-305
Collagen Organization and Biomechanics of the Arteries and Aneurysms of the Human Brain....Pages 307-322
Image-based Simulation of Blood Flow and Arterial Wall Interaction for Cerebral Aneurysms....Pages 323-335
Front Matter....Pages 337-337
A Framework for Soft Tissue and Musculo-skeletal Modelling: Clinical Uses and Future Challenges....Pages 339-354
Invariant Formulation for Dispersed Transverse Isotropy in Tissues of the Aortic Outflow Tract....Pages 355-368
Mathematical Modelling of Cardiac Mechanoenergetics....Pages 369-378
Creep and Relaxation in Ligament: Theory, Methods and Experiment....Pages 379-397
Viscoelastic Constitutive Law Based on the Time Scale of the Mechanical Phenomena....Pages 399-404
A Coupled FE Analysis of the Intervertebral Disc Based on a Multiphasic TPM Formulation....Pages 405-419
Is the Free Energy of Hydrogel the Sum of Elastic Energy and Ionic Energy?....Pages 421-430
In Vivo Experiments to Characterize the Mechanical Behavior of the Human Uterine Cervix....Pages 431-443
Viscoelastic Response of Vocal Fold Tissues and Scaffolds at High Frequencies....Pages 445-455
An Alternative Fabric-based Yield and Failure Criterion for Trabecular Bone....Pages 457-470
Front Matter....Pages 471-471
Functional Micro-imaging at the Interface of Bone Mechanics and Biology....Pages 473-487
Strain Measurement Using Deformable Image Registration....Pages 489-501
Image-based Hierarchical Analysis and Design of Tissue Engineering Scaffolds....Pages 503-515
Back Matter....Pages 517-522

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The mechanics of biological tissues is a multidisciplinary and rapidly expanding area of research. This book highlights some important research directions that combine mechanical sciences with exciting new developments in biology.

 

It includes state-of-the-art articles on:

• Tissue growth and remodelling – general continuum theories of growth, remodelling and adaptation, with specific applications to arterial, tendon and cartilage growth and to bone healing.
• Micromechanics, cells and matrix – measurements of the mechanical properties of cells, engineering of cell systems, constitutive and computational modelling of cells and cell-substrate interactions, and the transition from microscopic modelling to its macroscopic consequences.
• Arteries in health and disease – analysis of residual stress and its development, modelling the constitutive properties of arterial walls, computational analysis of the effect of stenting on the arterial wall, studies of collagen fibre distributions in saccular aneurysms and the interaction between blood flow and aneurysm development.
• Biological tissues – the musculo-skeletal system, heart valves, ligaments, intervertebral discs, the uterus and vocal fold tissues, with experimental, modelling and computational perspectives.
• Image-based analysis – illustration of imaging techniques that have great potential for the analysis of tissue properties and pathologies and for guiding the design of engineered tissue constructs.

 

This collection of papers should be of interest to theoretical, computational and experimental researchers and doctoral students in the area of biomechanics and in related areas of engineering, biology and medicine.

Content:
Front Matter....Pages I-XII
Front Matter....Pages 1-1
Towards a Theory of Vascular Growth and Remodeling....Pages 3-15
Complementary Roles of Theoretical Modeling and Computer-controlled Experimentation in Vascular Growth and Remodeling....Pages 17-28
On the Modeling of Growth and Adaptation....Pages 29-46
Growth in Soft Biological Tissue and Residual Stress Development....Pages 47-62
Characterization and Modeling of Growth and Remodeling in Tendon and Soft Tissue Constructs....Pages 63-75
Modeling and Simulation of Remodeling in Soft Biological Tissues....Pages 77-89
Anisotropic Remodelling of Biological Tissues....Pages 91-104
A Mechanobiological Formulation of Bone Healing....Pages 105-118
Continuum Models of Growth with Emphasis on Articular Cartilage....Pages 119-133
Front Matter....Pages 135-135
Tensile Properties and Local Stiffness of Cells....Pages 137-152
Microfluid-dynamics in Three-dimensional Engineered Cell Systems....Pages 153-164
Nonlinear Constitutive Models for Cochlear Outer Hair Cells....Pages 165-176
Prediction of Changes in Cell-substrate Contact under Cyclic Substrate Deformation Using Cohesive Zone Modelling....Pages 177-187
Micromechanics and Macromechanics of the Tensile Deformation of Nacre....Pages 189-203
Front Matter....Pages 205-205
Mechanical Properties of Atherosclerotic Tissues....Pages 207-223
Towards a Computational Methodology for Optimizing Angioplasty Treatments with Stenting....Pages 225-240
Computational Modeling of Stented Arteries: Considerations for Evolving Stent Designs....Pages 241-253
Simulation of In-stent Restenosis for the Design of Cardiovascular Stents....Pages 255-267
Material Property Alterations with Early Atheroma in an Animal Model....Pages 269-282
Microscopic Analysis of Residual Stress and Strain in the Aortic Media Considering Anisotropy of Smooth Muscle Layer....Pages 283-294
Front Matter....Pages 205-205
Parameter Identification in Arteries Using Constraints....Pages 295-305
Collagen Organization and Biomechanics of the Arteries and Aneurysms of the Human Brain....Pages 307-322
Image-based Simulation of Blood Flow and Arterial Wall Interaction for Cerebral Aneurysms....Pages 323-335
Front Matter....Pages 337-337
A Framework for Soft Tissue and Musculo-skeletal Modelling: Clinical Uses and Future Challenges....Pages 339-354
Invariant Formulation for Dispersed Transverse Isotropy in Tissues of the Aortic Outflow Tract....Pages 355-368
Mathematical Modelling of Cardiac Mechanoenergetics....Pages 369-378
Creep and Relaxation in Ligament: Theory, Methods and Experiment....Pages 379-397
Viscoelastic Constitutive Law Based on the Time Scale of the Mechanical Phenomena....Pages 399-404
A Coupled FE Analysis of the Intervertebral Disc Based on a Multiphasic TPM Formulation....Pages 405-419
Is the Free Energy of Hydrogel the Sum of Elastic Energy and Ionic Energy?....Pages 421-430
In Vivo Experiments to Characterize the Mechanical Behavior of the Human Uterine Cervix....Pages 431-443
Viscoelastic Response of Vocal Fold Tissues and Scaffolds at High Frequencies....Pages 445-455
An Alternative Fabric-based Yield and Failure Criterion for Trabecular Bone....Pages 457-470
Front Matter....Pages 471-471
Functional Micro-imaging at the Interface of Bone Mechanics and Biology....Pages 473-487
Strain Measurement Using Deformable Image Registration....Pages 489-501
Image-based Hierarchical Analysis and Design of Tissue Engineering Scaffolds....Pages 503-515
Back Matter....Pages 517-522
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