Ebook: Frontiers in Biochip Technology
Author: Haiching Ma Yuan Wang Amy S. Pomaybo Connie Tsai (auth.) Wan-Li Xing PhD Jing Cheng PhD (eds.)
- Tags: Biomedical Engineering, Biotechnology, Human Genetics, Pharmacology/Toxicology
- Year: 2006
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
Frontiers in Biochip Technology
Dr. Wan-Li Xing and Dr. Jing Cheng
Frontiers in Biochip Technology serves as an essential collection of new research in the field of biochip technology. This comprehensive collection covers emerging technologies and cutting –edge research in the field of biochip technology, with all chapters written by the international stars of this evolving field.
Key topics and current trends in biochip technology covered include:
-microarray technology and its applications
- microfluidics
- drug discovery
- detection technology
- lab-on-chip technology and bioinformatics.
Frontiers in Biochip Technology is an important volume for all biotechnologists, bioengineers, genetic engineers, pharmacological researchers, and general bench researchers who want to be up-to-date on the latest advances in the rapidly growing field of biochip technology.
The Editors:
Dr. Wan-Li Xing, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China
Dr. Xing is a Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, and also serves as the Executive Deputy Director at NERCBBT, CapitalBio Corporation, a world-leader in biochip research. Dr. Xing has published widely and obtained many patents and applications.
Dr. Jing Cheng, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China
Dr. Jing Cheng is the Cheung Kong Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, the Director of NERCBBT and CEO & CTO of CapitalBio. Dr. Cheng developed the world’s first system of laboratory-on-a-chip in 1998; this work was featured in the front-cover story of the June 1998 issue of Nature Biotechnology and cited as the breakthrough of the year by Science in the same year. He has been awarded Nanogen’s most prestigious award Nano Grant, Distinguished Achievement Award for Overseas Chinese Scholars Returned, China’s Science & Technology Award for Outstanding Youth, and Qiushi Technology Transfer Award for Outstanding Youth. Dr. Cheng has published over 90 peer-reviewed papers. In addition, he has obtained over 60 European and U.S. patents and applications.
Frontiers in Biochip Technology
Dr. Wan-Li Xing and Dr. Jing Cheng
Frontiers in Biochip Technology serves as an essential collection of new research in the field of biochip technology. This comprehensive collection covers emerging technologies and cutting –edge research in the field of biochip technology, with all chapters written by the international stars of this evolving field.
Key topics and current trends in biochip technology covered include:
-microarray technology and its applications
- microfluidics
- drug discovery
- detection technology
- lab-on-chip technology and bioinformatics.
Frontiers in Biochip Technology is an important volume for all biotechnologists, bioengineers, genetic engineers, pharmacological researchers, and general bench researchers who want to be up-to-date on the latest advances in the rapidly growing field of biochip technology.
The Editors:
Dr. Wan-Li Xing, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China
Dr. Xing is a Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, and also serves as the Executive Deputy Director at NERCBBT, CapitalBio Corporation, a world-leader in biochip research. Dr. Xing has published widely and obtained many patents and applications.
Dr. Jing Cheng, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China
Dr. Jing Cheng is the Cheung Kong Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, the Director of NERCBBT and CEO & CTO of CapitalBio. Dr. Cheng developed the world’s first system of laboratory-on-a-chip in 1998; this work was featured in the front-cover story of the June 1998 issue of Nature Biotechnology and cited as the breakthrough of the year by Science in the same year. He has been awarded Nanogen’s most prestigious award Nano Grant, Distinguished Achievement Award for Overseas Chinese Scholars Returned, China’s Science & Technology Award for Outstanding Youth, and Qiushi Technology Transfer Award for Outstanding Youth. Dr. Cheng has published over 90 peer-reviewed papers. In addition, he has obtained over 60 European and U.S. patents and applications.
Frontiers in Biochip Technology
Dr. Wan-Li Xing and Dr. Jing Cheng
Frontiers in Biochip Technology serves as an essential collection of new research in the field of biochip technology. This comprehensive collection covers emerging technologies and cutting –edge research in the field of biochip technology, with all chapters written by the international stars of this evolving field.
Key topics and current trends in biochip technology covered include:
-microarray technology and its applications
- microfluidics
- drug discovery
- detection technology
- lab-on-chip technology and bioinformatics.
Frontiers in Biochip Technology is an important volume for all biotechnologists, bioengineers, genetic engineers, pharmacological researchers, and general bench researchers who want to be up-to-date on the latest advances in the rapidly growing field of biochip technology.
The Editors:
Dr. Wan-Li Xing, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China
Dr. Xing is a Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, and also serves as the Executive Deputy Director at NERCBBT, CapitalBio Corporation, a world-leader in biochip research. Dr. Xing has published widely and obtained many patents and applications.
Dr. Jing Cheng, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China
Dr. Jing Cheng is the Cheung Kong Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, the Director of NERCBBT and CEO & CTO of CapitalBio. Dr. Cheng developed the world’s first system of laboratory-on-a-chip in 1998; this work was featured in the front-cover story of the June 1998 issue of Nature Biotechnology and cited as the breakthrough of the year by Science in the same year. He has been awarded Nanogen’s most prestigious award Nano Grant, Distinguished Achievement Award for Overseas Chinese Scholars Returned, China’s Science & Technology Award for Outstanding Youth, and Qiushi Technology Transfer Award for Outstanding Youth. Dr. Cheng has published over 90 peer-reviewed papers. In addition, he has obtained over 60 European and U.S. patents and applications.
Content:
Front Matter....Pages i-ix
Front Matter....Pages 1-1
A Homogenous Microarray for Enzymatic Functional Assays....Pages 3-18
Improvement of Microarray Technologies for Detecting Single Nucleotide Mismatch....Pages 19-60
Miniaturized Multiplexed Protein Binding Assays....Pages 61-87
MEA-Based Spike Recording in Cultured Neuronal Networks....Pages 88-98
Cell-Transistor Hybrid Systems....Pages 99-113
Front Matter....Pages 115-115
Microfabricated Chip Electrophoresis Technology for DNA Analysis....Pages 117-131
Microfabrication and Application of Recessed Gold Electrodes in Microchip Electrophoresis System....Pages 132-137
Fast Screening of Single-Nucleotide Polymorphisms Using Chip-Based Temperature Gradient Capillary Electrophoresis....Pages 138-143
Electro-Osmotic Flow Micro Pumps for Cell Positioning in Biochips....Pages 144-153
Front Matter....Pages 155-155
The Application of Novel Multi-Functional Microarray Slides for Immobilization Biomolecules....Pages 157-166
Novel Surface Technologies for Genomics, Proteomics, and Drug Discovery....Pages 167-175
Photoactivatable Silanes: Synthesis and Uses in Biopolymer Array Fabrication on Glass Substrates....Pages 176-188
Front Matter....Pages 189-189
An Integrated Biochemoinformatics System for Drug Discovery....Pages 191-206
Front Matter....Pages 207-207
Development of the MGX 4D Array System Utilizing Flow-Thru Chip Technology....Pages 209-230
Sequencing by Aligning Mutated DNA Fragments (SAM)....Pages 231-245
Fabrication of Double-Stranded DNA Microarray on Solid Surface for Studying DNA-Protein Interactions....Pages 246-273
Electronic Biosensors Based on DNA Self-Assembled Monolayer on Gold Electrodes....Pages 274-291
Front Matter....Pages 293-293
Multi-Parameter Read-Out in Miniaturized Format....Pages 295-310
Evaluation of the Reliability of cDNA Microarray Technique....Pages 311-323
High-Throughput Tissue Microarray Technology for the Rapid Clinical Translation of Genomic Discoveries....Pages 324-343
Back Matter....Pages 345-357
Frontiers in Biochip Technology
Dr. Wan-Li Xing and Dr. Jing Cheng
Frontiers in Biochip Technology serves as an essential collection of new research in the field of biochip technology. This comprehensive collection covers emerging technologies and cutting –edge research in the field of biochip technology, with all chapters written by the international stars of this evolving field.
Key topics and current trends in biochip technology covered include:
-microarray technology and its applications
- microfluidics
- drug discovery
- detection technology
- lab-on-chip technology and bioinformatics.
Frontiers in Biochip Technology is an important volume for all biotechnologists, bioengineers, genetic engineers, pharmacological researchers, and general bench researchers who want to be up-to-date on the latest advances in the rapidly growing field of biochip technology.
The Editors:
Dr. Wan-Li Xing, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China
Dr. Xing is a Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, and also serves as the Executive Deputy Director at NERCBBT, CapitalBio Corporation, a world-leader in biochip research. Dr. Xing has published widely and obtained many patents and applications.
Dr. Jing Cheng, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China
Dr. Jing Cheng is the Cheung Kong Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, the Director of NERCBBT and CEO & CTO of CapitalBio. Dr. Cheng developed the world’s first system of laboratory-on-a-chip in 1998; this work was featured in the front-cover story of the June 1998 issue of Nature Biotechnology and cited as the breakthrough of the year by Science in the same year. He has been awarded Nanogen’s most prestigious award Nano Grant, Distinguished Achievement Award for Overseas Chinese Scholars Returned, China’s Science & Technology Award for Outstanding Youth, and Qiushi Technology Transfer Award for Outstanding Youth. Dr. Cheng has published over 90 peer-reviewed papers. In addition, he has obtained over 60 European and U.S. patents and applications.
Content:
Front Matter....Pages i-ix
Front Matter....Pages 1-1
A Homogenous Microarray for Enzymatic Functional Assays....Pages 3-18
Improvement of Microarray Technologies for Detecting Single Nucleotide Mismatch....Pages 19-60
Miniaturized Multiplexed Protein Binding Assays....Pages 61-87
MEA-Based Spike Recording in Cultured Neuronal Networks....Pages 88-98
Cell-Transistor Hybrid Systems....Pages 99-113
Front Matter....Pages 115-115
Microfabricated Chip Electrophoresis Technology for DNA Analysis....Pages 117-131
Microfabrication and Application of Recessed Gold Electrodes in Microchip Electrophoresis System....Pages 132-137
Fast Screening of Single-Nucleotide Polymorphisms Using Chip-Based Temperature Gradient Capillary Electrophoresis....Pages 138-143
Electro-Osmotic Flow Micro Pumps for Cell Positioning in Biochips....Pages 144-153
Front Matter....Pages 155-155
The Application of Novel Multi-Functional Microarray Slides for Immobilization Biomolecules....Pages 157-166
Novel Surface Technologies for Genomics, Proteomics, and Drug Discovery....Pages 167-175
Photoactivatable Silanes: Synthesis and Uses in Biopolymer Array Fabrication on Glass Substrates....Pages 176-188
Front Matter....Pages 189-189
An Integrated Biochemoinformatics System for Drug Discovery....Pages 191-206
Front Matter....Pages 207-207
Development of the MGX 4D Array System Utilizing Flow-Thru Chip Technology....Pages 209-230
Sequencing by Aligning Mutated DNA Fragments (SAM)....Pages 231-245
Fabrication of Double-Stranded DNA Microarray on Solid Surface for Studying DNA-Protein Interactions....Pages 246-273
Electronic Biosensors Based on DNA Self-Assembled Monolayer on Gold Electrodes....Pages 274-291
Front Matter....Pages 293-293
Multi-Parameter Read-Out in Miniaturized Format....Pages 295-310
Evaluation of the Reliability of cDNA Microarray Technique....Pages 311-323
High-Throughput Tissue Microarray Technology for the Rapid Clinical Translation of Genomic Discoveries....Pages 324-343
Back Matter....Pages 345-357
....