Ebook: Mechanics of Elastic Biomolecules

A representative cross-section of elastic biomolecules is covered in this volume, which combines seventeen contributions from leading research groups. State-of-the-art molecular mechanics experiments are described dealing with the elasticity of DNA and nucleoprotein complexes, titin and titin-like proteins in muscle, as well as proteins of the cytoskeleton and the extracellular matrix.
The book speaks particularly to cell biologists, biophysicists, or bioengineers, and to senior researchers and graduate students alike, who are interested in recent advances in single-molecule technology (optical tweezers technique, atomic force microscopy), EM imaging, and computer simulation approaches to study nanobiomechanics. The findings discussed here have redefined our view of the role mechanical signals play in cellular functions and have greatly helped improve our understanding of biological elasticity in general.

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A representative cross-section of elastic biomolecules is covered in this volume, which combines seventeen contributions from leading research groups. State-of-the-art molecular mechanics experiments are described dealing with the elasticity of DNA and nucleoprotein complexes, titin and titin-like proteins in muscle, as well as proteins of the cytoskeleton and the extracellular matrix.
The book speaks particularly to cell biologists, biophysicists, or bioengineers, and to senior researchers and graduate students alike, who are interested in recent advances in single-molecule technology (optical tweezers technique, atomic force microscopy), EM imaging, and computer simulation approaches to study nanobiomechanics. The findings discussed here have redefined our view of the role mechanical signals play in cellular functions and have greatly helped improve our understanding of biological elasticity in general.

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A representative cross-section of elastic biomolecules is covered in this volume, which combines seventeen contributions from leading research groups. State-of-the-art molecular mechanics experiments are described dealing with the elasticity of DNA and nucleoprotein complexes, titin and titin-like proteins in muscle, as well as proteins of the cytoskeleton and the extracellular matrix.
The book speaks particularly to cell biologists, biophysicists, or bioengineers, and to senior researchers and graduate students alike, who are interested in recent advances in single-molecule technology (optical tweezers technique, atomic force microscopy), EM imaging, and computer simulation approaches to study nanobiomechanics. The findings discussed here have redefined our view of the role mechanical signals play in cellular functions and have greatly helped improve our understanding of biological elasticity in general.
Content:
Front Matter....Pages i-vii
Front Matter....Pages 365-365
Mechanics and imaging of single DNA molecules....Pages 367-375
Stretching and imaging single DNA molecules and chromatin....Pages 377-395
Optical tweezers stretching of chromatin....Pages 397-407
Micromechanical studies of mitotic chromosomes....Pages 409-431
Front Matter....Pages 433-433
Varieties of elastic protein in invertebrate muscles....Pages 435-447
Single-molecule measurement of elasticity of Serine-, Glutamate- and Lysine-Rich repeats of invertebrate connectin reveals that its elasticity is caused entropically by random coil structure....Pages 449-453
Front Matter....Pages 455-455
Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology....Pages 457-471
Species variations in cDNA sequence and exon splicing patterns in the extensible I-band region of cardiac titin: relation to passive tension....Pages 473-482
Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium....Pages 483-497
Stretching and visualizing titin molecules: combining structure, dynamics and mechanics....Pages 499-511
Unfolding of titin domains studied by molecular dynamics simulations....Pages 513-521
Front Matter....Pages 523-523
Mechanical response of single filamin A (ABP-280) molecules and its role in the actin cytoskeleton....Pages 525-534
Mechanics of vimentin intermediate filaments....Pages 535-540
Front Matter....Pages 541-541
Mechanics of elastin: molecular mechanism of biological elasticity and its relationship to contraction....Pages 543-559
Molecular basis for the extensibility of elastin....Pages 561-573
Stretching fibronectin....Pages 575-580
Fibrillin-rich microfibrils: elastic biopolymers of the extracellular matrix....Pages 581-596

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A representative cross-section of elastic biomolecules is covered in this volume, which combines seventeen contributions from leading research groups. State-of-the-art molecular mechanics experiments are described dealing with the elasticity of DNA and nucleoprotein complexes, titin and titin-like proteins in muscle, as well as proteins of the cytoskeleton and the extracellular matrix.
The book speaks particularly to cell biologists, biophysicists, or bioengineers, and to senior researchers and graduate students alike, who are interested in recent advances in single-molecule technology (optical tweezers technique, atomic force microscopy), EM imaging, and computer simulation approaches to study nanobiomechanics. The findings discussed here have redefined our view of the role mechanical signals play in cellular functions and have greatly helped improve our understanding of biological elasticity in general.
Content:
Front Matter....Pages i-vii
Front Matter....Pages 365-365
Mechanics and imaging of single DNA molecules....Pages 367-375
Stretching and imaging single DNA molecules and chromatin....Pages 377-395
Optical tweezers stretching of chromatin....Pages 397-407
Micromechanical studies of mitotic chromosomes....Pages 409-431
Front Matter....Pages 433-433
Varieties of elastic protein in invertebrate muscles....Pages 435-447
Single-molecule measurement of elasticity of Serine-, Glutamate- and Lysine-Rich repeats of invertebrate connectin reveals that its elasticity is caused entropically by random coil structure....Pages 449-453
Front Matter....Pages 455-455
Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology....Pages 457-471
Species variations in cDNA sequence and exon splicing patterns in the extensible I-band region of cardiac titin: relation to passive tension....Pages 473-482
Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium....Pages 483-497
Stretching and visualizing titin molecules: combining structure, dynamics and mechanics....Pages 499-511
Unfolding of titin domains studied by molecular dynamics simulations....Pages 513-521
Front Matter....Pages 523-523
Mechanical response of single filamin A (ABP-280) molecules and its role in the actin cytoskeleton....Pages 525-534
Mechanics of vimentin intermediate filaments....Pages 535-540
Front Matter....Pages 541-541
Mechanics of elastin: molecular mechanism of biological elasticity and its relationship to contraction....Pages 543-559
Molecular basis for the extensibility of elastin....Pages 561-573
Stretching fibronectin....Pages 575-580
Fibrillin-rich microfibrils: elastic biopolymers of the extracellular matrix....Pages 581-596
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