Ebook: Hypoxia: From Genes to the Bedside
- Tags: Anatomy, Cardiology, Biochemistry general, Biomedical Engineering
- Series: Advances in Experimental Medicine and Biology 502
- Year: 2001
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia.
Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.
Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia.
Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.
Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia.
Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.
Content:
Front Matter....Pages i-xv
John T. Reeves, MD....Pages 1-5
Genetic lessons from high altitude....Pages 7-11
Genes, environment, and exercise....Pages 13-20
Skeletal muscle angiogenesis....Pages 21-38
Leukocyte-endothelial interactions in environmental hypoxia....Pages 39-60
Hypoxia training for sea-level performance....Pages 61-73
The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise....Pages 75-88
Update: High altitude pulmonary edema....Pages 89-106
Phylogenetic comparison and artificial selection....Pages 107-132
Genetic and environmental adaptation in high altitude natives....Pages 133-151
Common themes of adaptation to hypoxia....Pages 153-167
Biology of erythropoietin....Pages 169-187
Lessons to better understanding of hypoxia sensing....Pages 189-205
Erythropoietin use and abuse....Pages 207-224
Mountaineering in thin air....Pages 225-236
Weight loss at high altitude....Pages 237-247
The heme oxygenase system and cellular defense mechanisms....Pages 249-272
Hypoxia-inducible factor in brain....Pages 273-291
Proton-gated cation channels — neuronal acid sensors in the central and peripheral nervous system....Pages 293-304
Structure function relationships of ENaC and its role in sodium handling....Pages 305-314
Transepithelial sodium and water transport in the lung....Pages 315-338
Is ventilatory acclimatization to hypoxia a phenomenon that arises through mechanisms that have an intrinsic role in the regulation of ventilation at sea level?....Pages 339-348
Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia....Pages 349-363
The pVHL-HIF-1 system....Pages 365-376
Interval hypoxic training....Pages 377-399
Gene transfer and metabolic modulators as new therapies for pulmonary hypertension....Pages 401-418
Chronic mountain sickness....Pages 419-437
International Working Group For Chronic Mountain Sickness....Pages 439-440
Late and Amended Abstracts....Pages 441-442
Back Matter....Pages 443-445
Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia.
Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.
Content:
Front Matter....Pages i-xv
John T. Reeves, MD....Pages 1-5
Genetic lessons from high altitude....Pages 7-11
Genes, environment, and exercise....Pages 13-20
Skeletal muscle angiogenesis....Pages 21-38
Leukocyte-endothelial interactions in environmental hypoxia....Pages 39-60
Hypoxia training for sea-level performance....Pages 61-73
The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise....Pages 75-88
Update: High altitude pulmonary edema....Pages 89-106
Phylogenetic comparison and artificial selection....Pages 107-132
Genetic and environmental adaptation in high altitude natives....Pages 133-151
Common themes of adaptation to hypoxia....Pages 153-167
Biology of erythropoietin....Pages 169-187
Lessons to better understanding of hypoxia sensing....Pages 189-205
Erythropoietin use and abuse....Pages 207-224
Mountaineering in thin air....Pages 225-236
Weight loss at high altitude....Pages 237-247
The heme oxygenase system and cellular defense mechanisms....Pages 249-272
Hypoxia-inducible factor in brain....Pages 273-291
Proton-gated cation channels — neuronal acid sensors in the central and peripheral nervous system....Pages 293-304
Structure function relationships of ENaC and its role in sodium handling....Pages 305-314
Transepithelial sodium and water transport in the lung....Pages 315-338
Is ventilatory acclimatization to hypoxia a phenomenon that arises through mechanisms that have an intrinsic role in the regulation of ventilation at sea level?....Pages 339-348
Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia....Pages 349-363
The pVHL-HIF-1 system....Pages 365-376
Interval hypoxic training....Pages 377-399
Gene transfer and metabolic modulators as new therapies for pulmonary hypertension....Pages 401-418
Chronic mountain sickness....Pages 419-437
International Working Group For Chronic Mountain Sickness....Pages 439-440
Late and Amended Abstracts....Pages 441-442
Back Matter....Pages 443-445
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