Ebook: Microreaction Technology: Proceedings of the First International Conference on Microreaction Technology

Microreaction technology is the logically consistent application of microsystem techniques in chemical reaction and process engineering. Miniaturization in this field is the strategy of success and requires the development of small, inexpensive, independent and versatile chemical reaction units. Microreaction technology is at present regarded as one of the fastest evolving and most promising disciplines in chemical engineering, combinatorial synthesis and analysis, pharmaceutical drug development and molecular biotechnology. A broad range of microstructurable materials is a prerequisite for microreaction technology and the development of microreactors goes hand in hand with the availability of a number of modem, versatile microfabrication technologies. Today, it is possible to manufacture tbree­ dimensional microstructures, almost without any restrictions with regard to design and choice of suitable materials, for various chemical applications -just in time to support the development of functional units for microreactors, e. g. micromixers, micro heat exchangers, micro extractors, units for phase transfer, reaction cham­ bers, intelligent fluidic control elements and microanalysis systems. The advantages of microreactors, e. g. the use of novel process routes, the re­ duction of reaction byproducts, the improvement of 'time to market', the high flexibility for all applications requiring modular solutions, have had a strong im­ pact on concepts of sustainable development. Many of the leading companies and research institutes in the world have recognized the tremendous possibilities of microreactor concepts and of their economic potential, and have thus initiated worldwide research and development activities.

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The First International Conference on Microreaction Technology will be a platform to exchange experience on the development, fabrication and performance of microreactors as well as on reactions in microchemical systems and their impact on industrial and laboratory applications.

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The First International Conference on Microreaction Technology will be a platform to exchange experience on the development, fabrication and performance of microreactors as well as on reactions in microchemical systems and their impact on industrial and laboratory applications.
Content:
Front Matter....Pages I-XIV
Front Matter....Pages 1-1
Reaction Engineering for Microreactor Systems....Pages 2-9
Observations on Hypothetical Miniaturised, Disposable Chemical Plant....Pages 10-19
Monolithic Microreactors Possessing Regular Mesopore Systems for the Succesful Performance of Heterogeneously Catalysed Reactions....Pages 20-26
Scouting Study About the Use of Microreactors for Gas Supply in a PEM Fuel Cell System for Traction....Pages 27-34
Solute Transfer by Liquid / Liquid Exchange Without Mixing in Micro-Contactor Devices....Pages 35-46
Reactions in Microreactors in Electric Fields....Pages 47-54
High-Temperature Micro Catalysis: a New Design for Comparative Reaction Studies in Technical and Model Systems....Pages 55-61
Micro-Structure Electrodes as Electronic Interface Between Solid and Gas Phase: Electrically Steerable Catalysts for Chemical Reactions in the Gas Phase....Pages 62-69
Front Matter....Pages 71-71
Fabrication of Components and Systems for Chemical and Biological Microreactors....Pages 72-90
Technologies and Microstructures for (Bio)chemical Microsystems....Pages 91-103
Functionalized Biomolecular Membranes for Microreactors....Pages 104-111
Nano Titer Plates: Micro Compartment Arrays for Biotechnological Applications....Pages 112-119
An Automated Method to Create a One Dimensional Array of Chemically Synthesized Oligonucleotides....Pages 120-126
Development of a Microreactor for Chemical Production....Pages 127-133
Laser Processes for Flexible Manufacturing of Fluidic Micro Reactors....Pages 134-137
The Use of Microcapillaries and Catalytic Contact Printing for the Preparation of Microstructured Magnetic Surfaces and for the Ordered Deposition of Proteins on Surfaces....Pages 138-145
Fabrication and Interconnection of Ceramic Microreaction Systems for High Temperature Applications....Pages 146-157
Fabrication of Microreactor Components by Electro Discharge Machining....Pages 158-168
Silicon Microreactors made by Reactive Ion Etching....Pages 169-174
Porous Silicon as the Carrier Martix in a Micro Enzyme Reactor to Achieve a Highly Efficient and Long-Term Stable Glucose Sensor....Pages 175-182
Front Matter....Pages 183-183
MCR X. Important Aspects for Automating Preparative Chemistry....Pages 184-189
MCR XII. Efficient Development of New Drugs by Online-Optimization of Molecular Libraries....Pages 190-194
MCR XI. Microreactors as Processors for Chemical Computers....Pages 195-202
Front Matter....Pages 203-203
Microfabricated Devices for Performing Chemical and Biochemical Analysis....Pages 204-218
A New Design of a Wafer Based Micro Reaction System....Pages 219-224
A Silicon Microreactor for Ulmmunological Applications....Pages 225-232
A Microfow Reactor for Two Dimensional Investigations of In Vitro Amplification Systems....Pages 233-244
Flourescence Correlation Spectroscopy (FCS), the Detection Method for Sub-Microliter Miniaturized Biological Assays....Pages 245-250
The Physiocontrol-Microsystem (PCM): Analysis of Cellular Behaviour for Biomedical Research....Pages 251-258
Development of a Pharmacological Test System in a Miniaturized Hollow Fiber Bioreactor....Pages 259-266
A Microreactor with On-line Mass Spectrometry for the Investigation of Biological Kinetics....Pages 267-274
Microarray Based Ligand Binding System....Pages 275-275
Front Matter....Pages 277-277
Advantages Afforded by Miniaturization and Integration of DNA Analysis Instrumentation....Pages 278-288
Nanoscaled Impedimetric Sensors for Multiparameter Testing of Biochemical Samples....Pages 289-293
Temperature Controlled Chip Reactor for Rapid PCR....Pages 294-301
Incremental Parallel Microtitration: A Novel Approach Towards Test Strip Devices of Extreme Accuracy....Pages 302-309
Concepts of Miniaturized and Fast GC and HPLC Analytical Systems Integrated in Microreactors....Pages 310-315
Possibilities for Thermophysical Reaction Monitoring in Microreactors....Pages 316-323
Heating and Calorimetry in Single Droplets and Micro Fluid Reactors....Pages 324-331
Microreactions on the Surface of an Oligonucleotide Bearing Chip....Pages 332-339
Front Matter....Pages 277-277
Coulometric Nanotitrators with Potentiometric Endpoint Detection....Pages 340-347
Miniaturization as a Demand of High-Throughput Synthesis and Analysis of Biomolecules....Pages 348-356

---

The First International Conference on Microreaction Technology will be a platform to exchange experience on the development, fabrication and performance of microreactors as well as on reactions in microchemical systems and their impact on industrial and laboratory applications.
Content:
Front Matter....Pages I-XIV
Front Matter....Pages 1-1
Reaction Engineering for Microreactor Systems....Pages 2-9
Observations on Hypothetical Miniaturised, Disposable Chemical Plant....Pages 10-19
Monolithic Microreactors Possessing Regular Mesopore Systems for the Succesful Performance of Heterogeneously Catalysed Reactions....Pages 20-26
Scouting Study About the Use of Microreactors for Gas Supply in a PEM Fuel Cell System for Traction....Pages 27-34
Solute Transfer by Liquid / Liquid Exchange Without Mixing in Micro-Contactor Devices....Pages 35-46
Reactions in Microreactors in Electric Fields....Pages 47-54
High-Temperature Micro Catalysis: a New Design for Comparative Reaction Studies in Technical and Model Systems....Pages 55-61
Micro-Structure Electrodes as Electronic Interface Between Solid and Gas Phase: Electrically Steerable Catalysts for Chemical Reactions in the Gas Phase....Pages 62-69
Front Matter....Pages 71-71
Fabrication of Components and Systems for Chemical and Biological Microreactors....Pages 72-90
Technologies and Microstructures for (Bio)chemical Microsystems....Pages 91-103
Functionalized Biomolecular Membranes for Microreactors....Pages 104-111
Nano Titer Plates: Micro Compartment Arrays for Biotechnological Applications....Pages 112-119
An Automated Method to Create a One Dimensional Array of Chemically Synthesized Oligonucleotides....Pages 120-126
Development of a Microreactor for Chemical Production....Pages 127-133
Laser Processes for Flexible Manufacturing of Fluidic Micro Reactors....Pages 134-137
The Use of Microcapillaries and Catalytic Contact Printing for the Preparation of Microstructured Magnetic Surfaces and for the Ordered Deposition of Proteins on Surfaces....Pages 138-145
Fabrication and Interconnection of Ceramic Microreaction Systems for High Temperature Applications....Pages 146-157
Fabrication of Microreactor Components by Electro Discharge Machining....Pages 158-168
Silicon Microreactors made by Reactive Ion Etching....Pages 169-174
Porous Silicon as the Carrier Martix in a Micro Enzyme Reactor to Achieve a Highly Efficient and Long-Term Stable Glucose Sensor....Pages 175-182
Front Matter....Pages 183-183
MCR X. Important Aspects for Automating Preparative Chemistry....Pages 184-189
MCR XII. Efficient Development of New Drugs by Online-Optimization of Molecular Libraries....Pages 190-194
MCR XI. Microreactors as Processors for Chemical Computers....Pages 195-202
Front Matter....Pages 203-203
Microfabricated Devices for Performing Chemical and Biochemical Analysis....Pages 204-218
A New Design of a Wafer Based Micro Reaction System....Pages 219-224
A Silicon Microreactor for Ulmmunological Applications....Pages 225-232
A Microfow Reactor for Two Dimensional Investigations of In Vitro Amplification Systems....Pages 233-244
Flourescence Correlation Spectroscopy (FCS), the Detection Method for Sub-Microliter Miniaturized Biological Assays....Pages 245-250
The Physiocontrol-Microsystem (PCM): Analysis of Cellular Behaviour for Biomedical Research....Pages 251-258
Development of a Pharmacological Test System in a Miniaturized Hollow Fiber Bioreactor....Pages 259-266
A Microreactor with On-line Mass Spectrometry for the Investigation of Biological Kinetics....Pages 267-274
Microarray Based Ligand Binding System....Pages 275-275
Front Matter....Pages 277-277
Advantages Afforded by Miniaturization and Integration of DNA Analysis Instrumentation....Pages 278-288
Nanoscaled Impedimetric Sensors for Multiparameter Testing of Biochemical Samples....Pages 289-293
Temperature Controlled Chip Reactor for Rapid PCR....Pages 294-301
Incremental Parallel Microtitration: A Novel Approach Towards Test Strip Devices of Extreme Accuracy....Pages 302-309
Concepts of Miniaturized and Fast GC and HPLC Analytical Systems Integrated in Microreactors....Pages 310-315
Possibilities for Thermophysical Reaction Monitoring in Microreactors....Pages 316-323
Heating and Calorimetry in Single Droplets and Micro Fluid Reactors....Pages 324-331
Microreactions on the Surface of an Oligonucleotide Bearing Chip....Pages 332-339
Front Matter....Pages 277-277
Coulometric Nanotitrators with Potentiometric Endpoint Detection....Pages 340-347
Miniaturization as a Demand of High-Throughput Synthesis and Analysis of Biomolecules....Pages 348-356
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