Ebook: Type 1 Diabetes: Etiology and Treatment

The increasing incidence of diabetes worldwide has prompted a rapid growth in the pace of scientific discovery and clinical understanding of this enigmatic disease. In Type 1 Diabetes: Etiology and Treatment, well-recognized physicians and researchers review the latest thinking about the causes of this condition and the best approaches to treating both its acute and chronic complications. The treatment options discussed range from life-threatening diabetic ketoacidosis to contemporary insulin regimens, from open- and closed-loop insulin delivery devices to modern glucose-sensing mechanisms, as well as such daily life issues as nutrition and education. Also discussed are the management of children under the age of five, the special problems of preadolescents and adolescents, diabetic surgery, and pregnancy, along with the treatment and prevention of the long-term vascular complications that produce coronary artery disease, the loss of limbs, end-stage renal disease, and blindness. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.
Authoritative and up-to-date, Type 1 Diabetes: Etiology and Treatment provides all those caring for diabetic patients with a concise, accessible survey of today's best thinking about the causes, treatment, and management of this complex disease.

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The increasing incidence of diabetes worldwide has prompted a rapid growth in the pace of scientific discovery and clinical understanding of this enigmatic disease. In Type 1 Diabetes: Etiology and Treatment, well-recognized physicians and researchers review the latest thinking about the causes of this condition and the best approaches to treating both its acute and chronic complications. The treatment options discussed range from life-threatening diabetic ketoacidosis to contemporary insulin regimens, from open- and closed-loop insulin delivery devices to modern glucose-sensing mechanisms, as well as such daily life issues as nutrition and education. Also discussed are the management of children under the age of five, the special problems of preadolescents and adolescents, diabetic surgery, and pregnancy, along with the treatment and prevention of the long-term vascular complications that produce coronary artery disease, the loss of limbs, end-stage renal disease, and blindness. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.
Authoritative and up-to-date, Type 1 Diabetes: Etiology and Treatment provides all those caring for diabetic patients with a concise, accessible survey of today's best thinking about the causes, treatment, and management of this complex disease.

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The increasing incidence of diabetes worldwide has prompted a rapid growth in the pace of scientific discovery and clinical understanding of this enigmatic disease. In Type 1 Diabetes: Etiology and Treatment, well-recognized physicians and researchers review the latest thinking about the causes of this condition and the best approaches to treating both its acute and chronic complications. The treatment options discussed range from life-threatening diabetic ketoacidosis to contemporary insulin regimens, from open- and closed-loop insulin delivery devices to modern glucose-sensing mechanisms, as well as such daily life issues as nutrition and education. Also discussed are the management of children under the age of five, the special problems of preadolescents and adolescents, diabetic surgery, and pregnancy, along with the treatment and prevention of the long-term vascular complications that produce coronary artery disease, the loss of limbs, end-stage renal disease, and blindness. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.
Authoritative and up-to-date, Type 1 Diabetes: Etiology and Treatment provides all those caring for diabetic patients with a concise, accessible survey of today's best thinking about the causes, treatment, and management of this complex disease.
Content:
Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Epidemiology of Type 1 Diabetes....Pages 3-22
Genetics of Type 1 Diabetes....Pages 23-54
Prediction and Prevention of Type 1 Diabetes....Pages 55-70
Molecular Biology of β-Cell Destruction by Autoimmune Processes....Pages 71-92
Type 1 Diabetes in Autoimmune Syndromes....Pages 93-114
The Metabolic Basis of Insulin Secretion....Pages 115-144
Prevention and Correction of Hypoglycemia....Pages 145-161
Nonautoimmune Forms of Diabetes....Pages 163-179
Front Matter....Pages 181-181
Diabetic Ketoacidosis....Pages 183-198
Insulin Regimens for Type 1 Diabetes....Pages 199-213
Relationship Between Metabolic Control and Complications in Diabetes....Pages 215-232
Open- and Closed-Loop Insulin Delivery Systems and Glucose Sensors....Pages 233-247
Living with Diabetes....Pages 249-260
Nutritional Management in Type 1 Diabetes....Pages 261-276
Front Matter....Pages 277-277
Special Problems and Management of the Child Less Than 5 Years of Age....Pages 279-292
The Preadolescent Child with Type 1 Diabetes....Pages 293-305
The Adolescent with Type 1 Diabetes....Pages 307-319
Hypoglycemia in Type 1 Diabetes....Pages 321-343
Pregnancy and Type 1 Diabetes....Pages 345-360
Surgery for the Patient with Type 1 Diabetes....Pages 361-371
Front Matter....Pages 373-373
Biochemistry and Molecular Biology of Diabetic Complications....Pages 375-392
The Eye....Pages 393-407
The Kidney....Pages 409-436
Diabetic Peripheral and Autonomic Neuropathy....Pages 437-461
The Diabetic Foot....Pages 463-471
Atherosclerosis in Type 1 Diabetes....Pages 473-483
Cutaneous Complications of Type 1 Diabetes....Pages 485-499
Infection and Diabetes....Pages 501-516
Pancreas Transplantation....Pages 517-527
Islet Transplantation....Pages 529-552
β-Cell Replacement Therapy for Type 1 Diabetes....Pages 553-560
Islet Growth Factors....Pages 561-577
Back Matter....Pages 579-593

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The increasing incidence of diabetes worldwide has prompted a rapid growth in the pace of scientific discovery and clinical understanding of this enigmatic disease. In Type 1 Diabetes: Etiology and Treatment, well-recognized physicians and researchers review the latest thinking about the causes of this condition and the best approaches to treating both its acute and chronic complications. The treatment options discussed range from life-threatening diabetic ketoacidosis to contemporary insulin regimens, from open- and closed-loop insulin delivery devices to modern glucose-sensing mechanisms, as well as such daily life issues as nutrition and education. Also discussed are the management of children under the age of five, the special problems of preadolescents and adolescents, diabetic surgery, and pregnancy, along with the treatment and prevention of the long-term vascular complications that produce coronary artery disease, the loss of limbs, end-stage renal disease, and blindness. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.
Authoritative and up-to-date, Type 1 Diabetes: Etiology and Treatment provides all those caring for diabetic patients with a concise, accessible survey of today's best thinking about the causes, treatment, and management of this complex disease.
Content:
Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Epidemiology of Type 1 Diabetes....Pages 3-22
Genetics of Type 1 Diabetes....Pages 23-54
Prediction and Prevention of Type 1 Diabetes....Pages 55-70
Molecular Biology of β-Cell Destruction by Autoimmune Processes....Pages 71-92
Type 1 Diabetes in Autoimmune Syndromes....Pages 93-114
The Metabolic Basis of Insulin Secretion....Pages 115-144
Prevention and Correction of Hypoglycemia....Pages 145-161
Nonautoimmune Forms of Diabetes....Pages 163-179
Front Matter....Pages 181-181
Diabetic Ketoacidosis....Pages 183-198
Insulin Regimens for Type 1 Diabetes....Pages 199-213
Relationship Between Metabolic Control and Complications in Diabetes....Pages 215-232
Open- and Closed-Loop Insulin Delivery Systems and Glucose Sensors....Pages 233-247
Living with Diabetes....Pages 249-260
Nutritional Management in Type 1 Diabetes....Pages 261-276
Front Matter....Pages 277-277
Special Problems and Management of the Child Less Than 5 Years of Age....Pages 279-292
The Preadolescent Child with Type 1 Diabetes....Pages 293-305
The Adolescent with Type 1 Diabetes....Pages 307-319
Hypoglycemia in Type 1 Diabetes....Pages 321-343
Pregnancy and Type 1 Diabetes....Pages 345-360
Surgery for the Patient with Type 1 Diabetes....Pages 361-371
Front Matter....Pages 373-373
Biochemistry and Molecular Biology of Diabetic Complications....Pages 375-392
The Eye....Pages 393-407
The Kidney....Pages 409-436
Diabetic Peripheral and Autonomic Neuropathy....Pages 437-461
The Diabetic Foot....Pages 463-471
Atherosclerosis in Type 1 Diabetes....Pages 473-483
Cutaneous Complications of Type 1 Diabetes....Pages 485-499
Infection and Diabetes....Pages 501-516
Pancreas Transplantation....Pages 517-527
Islet Transplantation....Pages 529-552
β-Cell Replacement Therapy for Type 1 Diabetes....Pages 553-560
Islet Growth Factors....Pages 561-577
Back Matter....Pages 579-593
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