Ebook: Folate and Human Development

Folic acid not only helps to prevent a variety of serious neural-tube birth defects-among them anencephaly and spina bifida-but is also an important factor in general human health. In Folate and Human Development, an authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural-tube defects.
Comprehensive and up-to-date, Folate and Human Development critically evaluates our current understanding of the role of folates in human health and disease, offering biomedical and clinical researchers a deeper understanding of the folate and nutrient basis of neural-tube defects.

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Folic acid not only helps to prevent a variety of serious neural-tube birth defects-among them anencephaly and spina bifida-but is also an important factor in general human health. In Folate and Human Development, an authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural-tube defects.
Comprehensive and up-to-date, Folate and Human Development critically evaluates our current understanding of the role of folates in human health and disease, offering biomedical and clinical researchers a deeper understanding of the folate and nutrient basis of neural-tube defects.

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Folic acid not only helps to prevent a variety of serious neural-tube birth defects-among them anencephaly and spina bifida-but is also an important factor in general human health. In Folate and Human Development, an authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural-tube defects.
Comprehensive and up-to-date, Folate and Human Development critically evaluates our current understanding of the role of folates in human health and disease, offering biomedical and clinical researchers a deeper understanding of the folate and nutrient basis of neural-tube defects.
Content:
Front Matter....Pages i-xii
Animal Models of Folate-Related Neural Tube Defects....Pages 1-26
Genetic Variation in Folate Metabolism....Pages 27-42
Folate Deficiency and the Molecular Determinants of Chromosome Instability....Pages 43-70
Folic Acid, Vitamin B12, and Genomic Stability of Human Cells....Pages 71-89
Molecular Genetics of Folate Metabolism....Pages 91-115
Folate Receptor-α....Pages 117-135
Folate, Homocysteine, and Neural Tube Defects....Pages 137-163
Folic Acid and Homocysteine as Risk Factors for Neural Tube Defects....Pages 165-181
Developmental Toxicants Potentially Acting via Folate Perturbation....Pages 183-203
Brain Development and Choline, the Other Methyl Donor....Pages 205-218
Nutrient Interactions Between Folate and Zinc or Copper....Pages 219-240
Regulation of Folate Metabolism by Iron....Pages 241-262
A Differential Role for Folate in Developmental Disorders, Vascular Disease, and Other Clinical Conditions....Pages 263-298
Vascular Disease in Women....Pages 299-328
Folate, Homocysteine, and Cardiovascular Disease....Pages 329-344
Back Matter....Pages 345-359

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Folic acid not only helps to prevent a variety of serious neural-tube birth defects-among them anencephaly and spina bifida-but is also an important factor in general human health. In Folate and Human Development, an authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural-tube defects.
Comprehensive and up-to-date, Folate and Human Development critically evaluates our current understanding of the role of folates in human health and disease, offering biomedical and clinical researchers a deeper understanding of the folate and nutrient basis of neural-tube defects.
Content:
Front Matter....Pages i-xii
Animal Models of Folate-Related Neural Tube Defects....Pages 1-26
Genetic Variation in Folate Metabolism....Pages 27-42
Folate Deficiency and the Molecular Determinants of Chromosome Instability....Pages 43-70
Folic Acid, Vitamin B12, and Genomic Stability of Human Cells....Pages 71-89
Molecular Genetics of Folate Metabolism....Pages 91-115
Folate Receptor-α....Pages 117-135
Folate, Homocysteine, and Neural Tube Defects....Pages 137-163
Folic Acid and Homocysteine as Risk Factors for Neural Tube Defects....Pages 165-181
Developmental Toxicants Potentially Acting via Folate Perturbation....Pages 183-203
Brain Development and Choline, the Other Methyl Donor....Pages 205-218
Nutrient Interactions Between Folate and Zinc or Copper....Pages 219-240
Regulation of Folate Metabolism by Iron....Pages 241-262
A Differential Role for Folate in Developmental Disorders, Vascular Disease, and Other Clinical Conditions....Pages 263-298
Vascular Disease in Women....Pages 299-328
Folate, Homocysteine, and Cardiovascular Disease....Pages 329-344
Back Matter....Pages 345-359
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