Ebook: Metals and Oxidative Damage in Neurological Disorders

The purpose of this book is to bring together scientists and clinicians interested in oxidative injury in the nervous system but whose approaches to investigation and treatment design vary widely. Indeed the goal of this book is to show that the investiga­ tive approaches and potential therapeutic interventions perhaps do not vary as widely as some may think. I think that the readers of this book will not read it from front to back, but will pick chapters of interest. Thus, the chapters are organized to contain information that is essential to understanding basic aspects of oxidative injury, and thus have some redundancy. However, within the context of each chapter the reader should hopefully find impetus and direction to go on to another chapter. The book is divided into three seetions. The first section contains reviews of metals and their role in generating oxidative injury. lron is considered in three of these chapters because of its relative abundance in the brain and its potency in inducing free radicals. The second section focuses on mechanisms by which the brain attempts to protect itself from oxidative injury. Some of these mechanisms have the potential to be protective in some situations and potentiaIly damaging in others. The third section contains the clinicaI diseases in which oxidative injury is known to contribute to the pathogenic process. This seetion ends with a chapter on antioxidant therapeutic strate­ gies in neurological disorders.

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Content:
Front Matter....Pages i-xxii
Iron and Neurotransmitter Function in the Brain....Pages 1-22
Evidence for Iron Mismanagement in the Brain in Neurological Disorders....Pages 23-39
Magnetic Resonance Imaging of Brain Iron....Pages 41-56
Neurochemical Roles of Copper as Antioxidant or Prooxidant....Pages 57-75
Manganese Neurotoxicity and Oxidative Damage....Pages 77-93
The Role of Zinc in Brain and Nerve Functions....Pages 95-111
Delivery of Metals to Brain and the Role of the Blood-Brain Barrier....Pages 113-130
Ferritin....Pages 131-147
Ascorbate....Pages 149-173
Vitamin E....Pages 175-188
Nitric Oxide and Oxidative Damage in the CNS....Pages 189-203
Iron and Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury Directions for Therapeutic Intervention....Pages 205-236
The Role of Oxidative Processes and Metal Ions in Aging and Alzheimer’s Disease....Pages 237-275
Oxidative Stress with Emphasis on the Role of LAMMA in Parkinson’s Disease....Pages 277-294
Perspectives on the Mechanisms of Familial Amyotrophic Lateral Sclerosis Caused by Mutations in Superoxide Dismutase 1....Pages 295-314
Tardive Dyskinesia and Oxidative Stress....Pages 315-324
Antioxidant Therapeutic Strategies in CNS Disorders....Pages 325-339
Oxidative Stress-Induced Cell Damage in the CNS....Pages 341-351
Back Matter....Pages 353-374

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Content:
Front Matter....Pages i-xxii
Iron and Neurotransmitter Function in the Brain....Pages 1-22
Evidence for Iron Mismanagement in the Brain in Neurological Disorders....Pages 23-39
Magnetic Resonance Imaging of Brain Iron....Pages 41-56
Neurochemical Roles of Copper as Antioxidant or Prooxidant....Pages 57-75
Manganese Neurotoxicity and Oxidative Damage....Pages 77-93
The Role of Zinc in Brain and Nerve Functions....Pages 95-111
Delivery of Metals to Brain and the Role of the Blood-Brain Barrier....Pages 113-130
Ferritin....Pages 131-147
Ascorbate....Pages 149-173
Vitamin E....Pages 175-188
Nitric Oxide and Oxidative Damage in the CNS....Pages 189-203
Iron and Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury Directions for Therapeutic Intervention....Pages 205-236
The Role of Oxidative Processes and Metal Ions in Aging and Alzheimer’s Disease....Pages 237-275
Oxidative Stress with Emphasis on the Role of LAMMA in Parkinson’s Disease....Pages 277-294
Perspectives on the Mechanisms of Familial Amyotrophic Lateral Sclerosis Caused by Mutations in Superoxide Dismutase 1....Pages 295-314
Tardive Dyskinesia and Oxidative Stress....Pages 315-324
Antioxidant Therapeutic Strategies in CNS Disorders....Pages 325-339
Oxidative Stress-Induced Cell Damage in the CNS....Pages 341-351
Back Matter....Pages 353-374
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