Ebook: The Kidney and Hypertension in Diabetes Mellitus

medical research covered in thisvolume: epidemiology, physiologyand pathophysio­ logy, laboratory methodology, and renal pathology. New studies deal with the diagnosis and treatment of both incipient and overt nephropathy by metabolie, antihypertensive, and dietary invention. Considerable progress has been made in the management of end-stage renal failure and also in the management and treatment of nephropathy in the pregnant diabetic woman. Diabetic nephropathy is a worldwide problem, but it is more clearly defined in Europe and North America where facilities for the diagnosis and treatment of diabetes and its complications are readily available. Much more work needs to be done in other parts of the world, as it appears from this book. It is hoped that we now have a handbook for the kidney and hypertension in diabetes and that further progress can be made in clinical work in diagnosing and treating diabetic patients. Much more work still needs to be done regarding patient education with respect to complications. Many diabetics have now been trained to take part in the management of their metabolie control; they should also be trained to take part in the follow-up and treatment of complications. This volume also underlines the considerable need for future research. So far, research in this field has been carried out in relatively few countries and centers in the world. The editor is sure that this volume will also stimulate further advan­ cement in clinical science within the field of diabetic renal disease.

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Content:
Front Matter....Pages i-xxvi
Definition of Diabetic Renal Disease in Insulin-Dependent Diabetes Mellitus Based on Renal Function Tests....Pages 1-14
Albuminuria and Renal Disease in NIDDM-Patients....Pages 15-26
Familial Factors in Diabetic Nephropathy....Pages 27-35
Hypertension, Cardiovascular Disease, Diabetes Mellitus, and Diabetic Nephropathy: Role of Insulin Resistance....Pages 37-51
Diabetes, Hypertension, and Kidney Disease in the Pima Indians Compared with Other Populations....Pages 53-62
Economic Evaluations of Strategies for Preventing Renal Disease in Non-Insulin Dependent Diabetes Mellitus....Pages 63-73
Incidence of Nephropathy in Insulin-Dependent Diabetes Mellitus as Related to Mortality and Cost-Benefit of Early Intervention....Pages 75-84
Measurement of Albumin and Other Urinary Proteins in Low Concentration in Diabetes Mellitus: Techniques and Clinical Significance....Pages 85-94
Office Tests for Microalbuminuria....Pages 95-102
Risk Factor for Progression of Microalbuminuria in Relatively Young NIDDM-Patients....Pages 103-109
The Clinical Course of Renal Disease in Caucasian NIDDM-Patients....Pages 111-121
Von Willebrand Factor and the Development of Renal and Vascular Complications in Diabetes....Pages 123-131
Smoking and Diabetic Nephropathy....Pages 133-140
Light Microscopy of Diabetic Glomerulopathy: The Classic Lesion....Pages 141-150
Haematuria and Diabetic Nephropathy....Pages 151-160
Glomerular Ultrastructural Changes in Microalbuminuric IDDM-Patients....Pages 161-170
Understanding of Diabetic Nephropathy from Kidney and Pancreas Transplantation....Pages 171-179
Sodium-Hydrogen Antiport, Cell Function and Susceptibility to Diabetic Nephropathy....Pages 181-189
Biochemical Aspects of Diabetic Nephropathy....Pages 191-202
The Steno Hypothesis and Glomerular Basement Membrane Biochemistry in Diabetic Nephropathy....Pages 203-212
Volume Homeostasis and Blood Pressure in Diabetic States....Pages 213-221
Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors....Pages 223-232
Roles of Growth Factors in Diabetic Kidney Disease....Pages 233-243
Blood Pressure Elevation in Diabetes: Results From 24-H Ambulatory Blood Pressure Recordings in Diabetes....Pages 245-259
Insulin and Blood Pressure....Pages 261-271
Cation Transport, Hypertension and Diabetic Nephropathy....Pages 273-283
Microalbuminuria in Young Patients with Type 1 Diabetes....Pages 285-295
Early Renal Hyperfunction and Hypertrophy in IDDM Patients Including Comments on Early Intervention....Pages 297-308
The Concept of Incipient Diabetic Nephropathy and Effect of Early Antihypertensive Intervention....Pages 309-318
Comparative Study of the Effect of Ace-Inhibitors and Other Antihypertensive Agents on Proteinuria in Diabetic Patients....Pages 319-332
Clinical Trials in Overt Diabetic Nephropathy....Pages 333-339
Antihypertensive Treatment in NIDDM, with Special Reference to Abnormal Albuminuria....Pages 341-351
The Course of Incipient and Overt Diabetic Nephropathy: The Perspective of More Optimal Insulin Treatment....Pages 353-360
Meta-Analysis of the Effect of Intensive Therapy on Nephropathy in Type I Diabetes Mellitus....Pages 361-368
Non-Glycaemic Intervention in Diabetic Nephropathy: The Role of Dietary Protein Intake....Pages 369-379
Microalbuminuria and Diabetic Pregnancy....Pages 381-388
Diabetic Nephropathy and Pregnancy....Pages 389-400
Urinary Tract Infection and Diabetes: Diagnosis and Treatment....Pages 401-405
Acute Renal Failure in Diabetics....Pages 407-419
Contrast Media-Induced Nephropathy in Diabetic Renal Disease....Pages 421-432
Renal Papillary Necrosis in Diabetic Patients....Pages 433-441
Problems Related to the Start of Renal Replacement Therapy in Diabetic Patients....Pages 443-447
Evolution Worldwide of the Treatment of Patients with Advanced Diabetic Nephropathy by Renal Replacement Therapy....Pages 449-458
Haemodialysis in Type 1 and Type 2 Diabetic Patients with end Stage Renal Failure....Pages 459-467
Continuous Ambulatory Peritoneal Dialysis in Uremic Diabetics....Pages 469-485
Simultaneous Pancreas and Kidney Transplantation: Indication and Results....Pages 487-494
Renal Transplantation for Diabetic Nephropathy....Pages 495-514
St Vincent Declaration, 1994: Guidelines for the Prevention of Diabetic Renal Failure....Pages 515-527
Back Matter....Pages 529-547

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Content:
Front Matter....Pages i-xxvi
Definition of Diabetic Renal Disease in Insulin-Dependent Diabetes Mellitus Based on Renal Function Tests....Pages 1-14
Albuminuria and Renal Disease in NIDDM-Patients....Pages 15-26
Familial Factors in Diabetic Nephropathy....Pages 27-35
Hypertension, Cardiovascular Disease, Diabetes Mellitus, and Diabetic Nephropathy: Role of Insulin Resistance....Pages 37-51
Diabetes, Hypertension, and Kidney Disease in the Pima Indians Compared with Other Populations....Pages 53-62
Economic Evaluations of Strategies for Preventing Renal Disease in Non-Insulin Dependent Diabetes Mellitus....Pages 63-73
Incidence of Nephropathy in Insulin-Dependent Diabetes Mellitus as Related to Mortality and Cost-Benefit of Early Intervention....Pages 75-84
Measurement of Albumin and Other Urinary Proteins in Low Concentration in Diabetes Mellitus: Techniques and Clinical Significance....Pages 85-94
Office Tests for Microalbuminuria....Pages 95-102
Risk Factor for Progression of Microalbuminuria in Relatively Young NIDDM-Patients....Pages 103-109
The Clinical Course of Renal Disease in Caucasian NIDDM-Patients....Pages 111-121
Von Willebrand Factor and the Development of Renal and Vascular Complications in Diabetes....Pages 123-131
Smoking and Diabetic Nephropathy....Pages 133-140
Light Microscopy of Diabetic Glomerulopathy: The Classic Lesion....Pages 141-150
Haematuria and Diabetic Nephropathy....Pages 151-160
Glomerular Ultrastructural Changes in Microalbuminuric IDDM-Patients....Pages 161-170
Understanding of Diabetic Nephropathy from Kidney and Pancreas Transplantation....Pages 171-179
Sodium-Hydrogen Antiport, Cell Function and Susceptibility to Diabetic Nephropathy....Pages 181-189
Biochemical Aspects of Diabetic Nephropathy....Pages 191-202
The Steno Hypothesis and Glomerular Basement Membrane Biochemistry in Diabetic Nephropathy....Pages 203-212
Volume Homeostasis and Blood Pressure in Diabetic States....Pages 213-221
Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors....Pages 223-232
Roles of Growth Factors in Diabetic Kidney Disease....Pages 233-243
Blood Pressure Elevation in Diabetes: Results From 24-H Ambulatory Blood Pressure Recordings in Diabetes....Pages 245-259
Insulin and Blood Pressure....Pages 261-271
Cation Transport, Hypertension and Diabetic Nephropathy....Pages 273-283
Microalbuminuria in Young Patients with Type 1 Diabetes....Pages 285-295
Early Renal Hyperfunction and Hypertrophy in IDDM Patients Including Comments on Early Intervention....Pages 297-308
The Concept of Incipient Diabetic Nephropathy and Effect of Early Antihypertensive Intervention....Pages 309-318
Comparative Study of the Effect of Ace-Inhibitors and Other Antihypertensive Agents on Proteinuria in Diabetic Patients....Pages 319-332
Clinical Trials in Overt Diabetic Nephropathy....Pages 333-339
Antihypertensive Treatment in NIDDM, with Special Reference to Abnormal Albuminuria....Pages 341-351
The Course of Incipient and Overt Diabetic Nephropathy: The Perspective of More Optimal Insulin Treatment....Pages 353-360
Meta-Analysis of the Effect of Intensive Therapy on Nephropathy in Type I Diabetes Mellitus....Pages 361-368
Non-Glycaemic Intervention in Diabetic Nephropathy: The Role of Dietary Protein Intake....Pages 369-379
Microalbuminuria and Diabetic Pregnancy....Pages 381-388
Diabetic Nephropathy and Pregnancy....Pages 389-400
Urinary Tract Infection and Diabetes: Diagnosis and Treatment....Pages 401-405
Acute Renal Failure in Diabetics....Pages 407-419
Contrast Media-Induced Nephropathy in Diabetic Renal Disease....Pages 421-432
Renal Papillary Necrosis in Diabetic Patients....Pages 433-441
Problems Related to the Start of Renal Replacement Therapy in Diabetic Patients....Pages 443-447
Evolution Worldwide of the Treatment of Patients with Advanced Diabetic Nephropathy by Renal Replacement Therapy....Pages 449-458
Haemodialysis in Type 1 and Type 2 Diabetic Patients with end Stage Renal Failure....Pages 459-467
Continuous Ambulatory Peritoneal Dialysis in Uremic Diabetics....Pages 469-485
Simultaneous Pancreas and Kidney Transplantation: Indication and Results....Pages 487-494
Renal Transplantation for Diabetic Nephropathy....Pages 495-514
St Vincent Declaration, 1994: Guidelines for the Prevention of Diabetic Renal Failure....Pages 515-527
Back Matter....Pages 529-547
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