Ebook: Advances in Myocardiology: Volume 4

This volume of Advances in Myocardiology is derived from a part of the proceedings of the 10th Congress of the International Society for Heart Research, which was held in Moscow on September 23-29, 1980. This book contains selected papers which have been arranged in two sections, Cardiac Hypertrophy, Adaptation, and Pathophysiology and Cardiac Hypoxia, Is­ chemia, and Infarction. The first section, on the pathophysiology of heart hypertrophy and failure, contains 24 chapters that focus on the derangement of biochemical, physiological, and immunological processes during the de­ velopment of heart disease due to a wide variety of pathogenic factors. Some of the recent developments in understanding the myocardial synthetic ma­ chinery in heart hypertrophy are also described in these papers, and we believe that the contents of this section will stimulate further research in the area of heart disease. The second section, which mainly deals with myocardial ischemia, contains 35 chapters providing the necessary back­ ground for the diagnosis of ischemic heart disease and some possible ther­ apeutic approaches. It hardly needs to be emphasized that ischemic heart disease is a major cause of death in highly industrialized countries, but unfortunately the exact mechanism by which ischemic insult leads to the development of heart cell damage is far from understood. We are hopeful that the articles in this section will provide valuable information in this field and thus will help in improving the treatment of ischemic heart disease.

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Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Pathogenesis and Prophylaxis of Cardiac Lesions in Stress....Pages 3-21
Energy Metabolism of the Heart in Catecholamine-Induced Myocardial Injury....Pages 23-43
The Permissive Role of Catecholamines in the Pathogenesis of Hamster Cardiomyopathy....Pages 45-53
Adaptive and Pathological Alterations in Experimental Cardiac Hypertrophy....Pages 55-77
Reflections on What Makes the Heart Grow....Pages 79-85
Force-Velocity-Length Relationship during Cardiac Hypertrophy....Pages 87-95
Hemodynamics, Regional Myocardial Blood Flow, and Sarcoplasmic Reticulum Calcium Uptake in Right Ventricular Hypertrophy and Failure....Pages 97-105
Myocardial Energy Metabolism of Congestive and Hypertrophic Cardiomyopathy in Man....Pages 107-113
Effects of Cardiac Work and Leucine on Protein Turnover....Pages 115-125
The Rate of Cardiac Structural Protein Synthesis in Perfused Heart....Pages 127-135
DNA Synthesis and Mitotic Activity in Adult Atrial Cardiocytes in Culture....Pages 137-145
DNA Synthesis in Atrial Myocytes of Rats with Aortic Stenosis....Pages 147-162
DNA Synthetic Activity of Right and Left Ventricular Biopsy Specimens in Patients with Cardiomyopathy....Pages 163-170
Comparative Changes in the 32P Labeling of Adenine and Uracil Nucleotides in the Hypertrophying Rat Heart....Pages 171-181
Increased Synthesis of the Phosphorylated Form of the Myosin Light Chains in Cardiac Hypertrophy in the Rat....Pages 183-188
Reconstitution of Heavy Chain and Light Chain 1 in Cardiac Subfragment-1 from Hyperthyroid and Euthyroid Rabbit Hearts....Pages 189-193
Mechanisms of Degradation of Myofibrillar and Nonmyofibrillar Protein in Heart....Pages 195-199
Vasoactive Peptides and Regulation of Hemodynamics in Different Functional States of the Organism....Pages 201-214
Pathogenesis of Immune-Mediated Carditis in Monkeys....Pages 215-226
Immunologic Studies in Infective Endocarditis....Pages 227-232
Front Matter....Pages 1-1
Adaptation of the Organism during Long-Lasting Survival with a Total Artificial Heart....Pages 233-246
A Possible Mechanism of Adriamycin Cardiotoxicity....Pages 247-253
Effects of Propranolol and Hydrocortisone Pretreatment on Radiation-Induced Myocardial Injury in Rats....Pages 255-262
Inhibition of Vitamin D3-Induced Vascular Calcification by Carbocromen....Pages 263-267
Front Matter....Pages 269-269
Mitochondrial Function in Normal and Hypoxic States of the Myocardium....Pages 271-285
Cardiac Synthesis and Degradation of Pyridine Nucleotides and the Level of Energy-Rich Phosphates Influenced by Various Precursors....Pages 287-308
Effect of Exogenous Amino Acids on the Contractility and Nitrogenous Metabolism of Anoxic Heart....Pages 309-318
Regulation of Cardiac Contractility and Glycolysis by Cyclic Nucleotides during Hypoxia....Pages 319-325
Hypoxia, Calcium, and Contracture as Mediators of Myocardial Enzyme Release....Pages 327-331
Cyclic AMP and Early Contractile Failure....Pages 333-338
Release of Purine Nucleosides and Oxypurines from the Isolated Perfused Rat Heart....Pages 339-345
Pathophysiology of Irreversible Ischemic Injury....Pages 347-361
Acid Hydrolases in the Initiation of Ischemic Myocardial Necrosis....Pages 363-369
Release of Prostacyclin into the Coronary Venous Blood in Patients with Coronary Arterial Disease....Pages 371-378
The Effects of Systole on Left Ventricular Blood Flow....Pages 379-393
Prolonged Depletion of ATP Because of Delayed Repletion of the Adenine Nucleotide Pool following Reversible Myocardial Ischemic Injury in Dogs....Pages 395-407
Cytochrome Oxidase Activity of Mitochondria from Ischemic and Reperfused Myocardium....Pages 409-418
The Effect of Experimentally Induced Myocardial Ischemia on the Norepinephrine Metabolism of the Dog Heart....Pages 419-425
Reperfusion Injury....Pages 427-439
Ultrastructural, Functional, and Metabolic Correlates in the Ischemic Rat Heart....Pages 441-448
Front Matter....Pages 269-269
Detection of Intracellular Anoxia and Its Relationship to Onset of Hemodynamic Dysfunction and ST-Segment Elevation in the Intact Dog Heart....Pages 449-456
The Relationship between Glucose Utilization during Ischemia and Ventricular Fibrillation during Early Reperfusion....Pages 457-464
Correlation among Water Content, Left Ventricular Function, Coronary Blood Flow, and Myocardial Metabolism after Hypothermic Ischemic Cardiac Arrest....Pages 465-471
Serial Changes in Cytosolic, Mitochondrial, and Lysosomal Enzymes and Cardiac Myosin Light Chain II in Plasma following Coronary Ligation in Conscious Closed-Chest Dogs....Pages 473-478
Myosin Light Chain Phosphorylation during Regional Myocardial Ischemia....Pages 479-487
Myocardial Infarct Size from Serum Cardiac Myosin Light Chain....Pages 489-495
Biopsy Assessment of Preservation during Open-Heart Surgery with Cold Cardioplegic Arrest....Pages 497-504
Calcium Antagonistic Activity and Myocardial Ischemic Protection by Both Stereoisomers of Verapamil....Pages 505-512
The Effects of β Blockade and Partial Agonist Activity during Myocardial Ischemia....Pages 513-520
Cyclic Nucleotides and Changes in Protein Kinase Activity Ratio in the Ischemic and Nonischemic Myocardium....Pages 521-530
Myocardial Biosynthesis of Prostaglandins with Special Consideration of Prostacyclin and the Influence of Dipyridamole and Propranolol....Pages 531-537
Influence of Cardiovascular Drugs on Platelet Aggregation....Pages 539-547
Effects of L-Carnitine on Tissue Levels of Free Fatty Acid, Acyl CoA, and Acylcarnitine in Ischemic Heart....Pages 549-557
Effect of Coenzyme Q10 on Hypertrophied Ischemic Myocardium during Aortic Cross Clamping for 2 hr, from the Aspect of Energy Metabolism....Pages 559-566
Preservation of Oxidative Phosphorylation by Lidocaine in Ischemic and Reperfused Myocardium....Pages 567-573
On the Mechanism of Action of the Antianginal Drug Nonachlazine on Ischemic Myocardium....Pages 575-587
Studies on Slow Cardiac Action Potentials Occurring in Potassium-Rich Media as a Simulation of the Early Phase of Myocardial Infarction....Pages 589-594
Antiischemic Effects of Molsidomine in an Experimental Model of Coronary Artery Stenosis....Pages 595-604
Effect of Molsidomine on Spontaneous Ventricular Fibrillation following Myocardial Ischemia and Reperfusion in the Dog....Pages 605-613
Back Matter....Pages 615-649

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Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Pathogenesis and Prophylaxis of Cardiac Lesions in Stress....Pages 3-21
Energy Metabolism of the Heart in Catecholamine-Induced Myocardial Injury....Pages 23-43
The Permissive Role of Catecholamines in the Pathogenesis of Hamster Cardiomyopathy....Pages 45-53
Adaptive and Pathological Alterations in Experimental Cardiac Hypertrophy....Pages 55-77
Reflections on What Makes the Heart Grow....Pages 79-85
Force-Velocity-Length Relationship during Cardiac Hypertrophy....Pages 87-95
Hemodynamics, Regional Myocardial Blood Flow, and Sarcoplasmic Reticulum Calcium Uptake in Right Ventricular Hypertrophy and Failure....Pages 97-105
Myocardial Energy Metabolism of Congestive and Hypertrophic Cardiomyopathy in Man....Pages 107-113
Effects of Cardiac Work and Leucine on Protein Turnover....Pages 115-125
The Rate of Cardiac Structural Protein Synthesis in Perfused Heart....Pages 127-135
DNA Synthesis and Mitotic Activity in Adult Atrial Cardiocytes in Culture....Pages 137-145
DNA Synthesis in Atrial Myocytes of Rats with Aortic Stenosis....Pages 147-162
DNA Synthetic Activity of Right and Left Ventricular Biopsy Specimens in Patients with Cardiomyopathy....Pages 163-170
Comparative Changes in the 32P Labeling of Adenine and Uracil Nucleotides in the Hypertrophying Rat Heart....Pages 171-181
Increased Synthesis of the Phosphorylated Form of the Myosin Light Chains in Cardiac Hypertrophy in the Rat....Pages 183-188
Reconstitution of Heavy Chain and Light Chain 1 in Cardiac Subfragment-1 from Hyperthyroid and Euthyroid Rabbit Hearts....Pages 189-193
Mechanisms of Degradation of Myofibrillar and Nonmyofibrillar Protein in Heart....Pages 195-199
Vasoactive Peptides and Regulation of Hemodynamics in Different Functional States of the Organism....Pages 201-214
Pathogenesis of Immune-Mediated Carditis in Monkeys....Pages 215-226
Immunologic Studies in Infective Endocarditis....Pages 227-232
Front Matter....Pages 1-1
Adaptation of the Organism during Long-Lasting Survival with a Total Artificial Heart....Pages 233-246
A Possible Mechanism of Adriamycin Cardiotoxicity....Pages 247-253
Effects of Propranolol and Hydrocortisone Pretreatment on Radiation-Induced Myocardial Injury in Rats....Pages 255-262
Inhibition of Vitamin D3-Induced Vascular Calcification by Carbocromen....Pages 263-267
Front Matter....Pages 269-269
Mitochondrial Function in Normal and Hypoxic States of the Myocardium....Pages 271-285
Cardiac Synthesis and Degradation of Pyridine Nucleotides and the Level of Energy-Rich Phosphates Influenced by Various Precursors....Pages 287-308
Effect of Exogenous Amino Acids on the Contractility and Nitrogenous Metabolism of Anoxic Heart....Pages 309-318
Regulation of Cardiac Contractility and Glycolysis by Cyclic Nucleotides during Hypoxia....Pages 319-325
Hypoxia, Calcium, and Contracture as Mediators of Myocardial Enzyme Release....Pages 327-331
Cyclic AMP and Early Contractile Failure....Pages 333-338
Release of Purine Nucleosides and Oxypurines from the Isolated Perfused Rat Heart....Pages 339-345
Pathophysiology of Irreversible Ischemic Injury....Pages 347-361
Acid Hydrolases in the Initiation of Ischemic Myocardial Necrosis....Pages 363-369
Release of Prostacyclin into the Coronary Venous Blood in Patients with Coronary Arterial Disease....Pages 371-378
The Effects of Systole on Left Ventricular Blood Flow....Pages 379-393
Prolonged Depletion of ATP Because of Delayed Repletion of the Adenine Nucleotide Pool following Reversible Myocardial Ischemic Injury in Dogs....Pages 395-407
Cytochrome Oxidase Activity of Mitochondria from Ischemic and Reperfused Myocardium....Pages 409-418
The Effect of Experimentally Induced Myocardial Ischemia on the Norepinephrine Metabolism of the Dog Heart....Pages 419-425
Reperfusion Injury....Pages 427-439
Ultrastructural, Functional, and Metabolic Correlates in the Ischemic Rat Heart....Pages 441-448
Front Matter....Pages 269-269
Detection of Intracellular Anoxia and Its Relationship to Onset of Hemodynamic Dysfunction and ST-Segment Elevation in the Intact Dog Heart....Pages 449-456
The Relationship between Glucose Utilization during Ischemia and Ventricular Fibrillation during Early Reperfusion....Pages 457-464
Correlation among Water Content, Left Ventricular Function, Coronary Blood Flow, and Myocardial Metabolism after Hypothermic Ischemic Cardiac Arrest....Pages 465-471
Serial Changes in Cytosolic, Mitochondrial, and Lysosomal Enzymes and Cardiac Myosin Light Chain II in Plasma following Coronary Ligation in Conscious Closed-Chest Dogs....Pages 473-478
Myosin Light Chain Phosphorylation during Regional Myocardial Ischemia....Pages 479-487
Myocardial Infarct Size from Serum Cardiac Myosin Light Chain....Pages 489-495
Biopsy Assessment of Preservation during Open-Heart Surgery with Cold Cardioplegic Arrest....Pages 497-504
Calcium Antagonistic Activity and Myocardial Ischemic Protection by Both Stereoisomers of Verapamil....Pages 505-512
The Effects of β Blockade and Partial Agonist Activity during Myocardial Ischemia....Pages 513-520
Cyclic Nucleotides and Changes in Protein Kinase Activity Ratio in the Ischemic and Nonischemic Myocardium....Pages 521-530
Myocardial Biosynthesis of Prostaglandins with Special Consideration of Prostacyclin and the Influence of Dipyridamole and Propranolol....Pages 531-537
Influence of Cardiovascular Drugs on Platelet Aggregation....Pages 539-547
Effects of L-Carnitine on Tissue Levels of Free Fatty Acid, Acyl CoA, and Acylcarnitine in Ischemic Heart....Pages 549-557
Effect of Coenzyme Q10 on Hypertrophied Ischemic Myocardium during Aortic Cross Clamping for 2 hr, from the Aspect of Energy Metabolism....Pages 559-566
Preservation of Oxidative Phosphorylation by Lidocaine in Ischemic and Reperfused Myocardium....Pages 567-573
On the Mechanism of Action of the Antianginal Drug Nonachlazine on Ischemic Myocardium....Pages 575-587
Studies on Slow Cardiac Action Potentials Occurring in Potassium-Rich Media as a Simulation of the Early Phase of Myocardial Infarction....Pages 589-594
Antiischemic Effects of Molsidomine in an Experimental Model of Coronary Artery Stenosis....Pages 595-604
Effect of Molsidomine on Spontaneous Ventricular Fibrillation following Myocardial Ischemia and Reperfusion in the Dog....Pages 605-613
Back Matter....Pages 615-649
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