Ebook: Targeted Molecular Imaging in Oncology

Cancer cells dedifferentiate with repect to cell function; their vascularity is more leaky, but perfusion is heterogenerously reduced, and interstitial fluid pressure is high, severely retarding delivery of agents from the blood. Targeted imaging is designed to produce a detectable difference between tissue that is visualized with single photon and positron emission tomography, magnetic resonance imaging, computed tomography, or ultrasonography. This book uniquely reports strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. This book also describes updated information about the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

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Content:
Front Matter....Pages i-xvi
Principles of Basic Sciences Related to Cancer....Pages 1-13
Imaging Strategies and Perspectives in Oncology....Pages 14-18
Principles of Single Photon Emission Computed Tomography and Positron Emission Tomography....Pages 19-29
Principles of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy....Pages 30-61
Radiopharmaceuticals for Tumor-Targeted Imaging: Overview....Pages 62-82
Antibodies for Targeted Imaging: Properties and Radiolabeling....Pages 83-87
Radioimmunodetection of Cancer....Pages 88-101
Peptide Receptor Imaging....Pages 102-110
Polymer-Based Compounds for Targeted Imaging....Pages 111-120
Targeted Single Photon Emission Computed Tomography in Oncology....Pages 121-133
Targeted Positron Emission Tomography in Oncology....Pages 134-154
Targeted Magnetic Resonance Imaging Contrast Agents....Pages 155-163
Magnetic Resonance Characteristics of Tumors....Pages 164-171
Targeted Imaging of Lymph Nodes....Pages 172-178
Computed Tomography and Ultrasound Contrast Agents....Pages 179-184
Imaging of Anticancer Drugs for Therapeutic Response and Prognosis....Pages 185-199
Imaging of Angiogenesis....Pages 200-214
Imaging of Apoptosis and Hypoxia....Pages 215-228
Imaging of Signal Transduction and Antisense Imaging....Pages 229-244
Imaging of Gene Delivery and Expression....Pages 245-259
Back Matter....Pages 273-289
Optical Imaging and In Vivo Microscopy....Pages 260-271

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Content:
Front Matter....Pages i-xvi
Principles of Basic Sciences Related to Cancer....Pages 1-13
Imaging Strategies and Perspectives in Oncology....Pages 14-18
Principles of Single Photon Emission Computed Tomography and Positron Emission Tomography....Pages 19-29
Principles of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy....Pages 30-61
Radiopharmaceuticals for Tumor-Targeted Imaging: Overview....Pages 62-82
Antibodies for Targeted Imaging: Properties and Radiolabeling....Pages 83-87
Radioimmunodetection of Cancer....Pages 88-101
Peptide Receptor Imaging....Pages 102-110
Polymer-Based Compounds for Targeted Imaging....Pages 111-120
Targeted Single Photon Emission Computed Tomography in Oncology....Pages 121-133
Targeted Positron Emission Tomography in Oncology....Pages 134-154
Targeted Magnetic Resonance Imaging Contrast Agents....Pages 155-163
Magnetic Resonance Characteristics of Tumors....Pages 164-171
Targeted Imaging of Lymph Nodes....Pages 172-178
Computed Tomography and Ultrasound Contrast Agents....Pages 179-184
Imaging of Anticancer Drugs for Therapeutic Response and Prognosis....Pages 185-199
Imaging of Angiogenesis....Pages 200-214
Imaging of Apoptosis and Hypoxia....Pages 215-228
Imaging of Signal Transduction and Antisense Imaging....Pages 229-244
Imaging of Gene Delivery and Expression....Pages 245-259
Back Matter....Pages 273-289
Optical Imaging and In Vivo Microscopy....Pages 260-271
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