Ebook: Synthesis and Release of Adenohypophyseal Hormones

In September, 1977, at a conference organized by Dr. Kenneth McKerns in Northeast Harbor, Maine, USA, I was asked by the Editorial Committee of the Biochemical Endocrinology series to investigate the possibility of organizing the next meeting in France. I proposed a subject which is in the area of my research interest, and this subject was accepted. On arriving back in France, I first looked for an appropriate place for the meeting, and the Chateau de Seillac was chosen in accordance with many objective criteria. We know that all who attended the meeting held in Seillac enjoyed this quiet and charming place in the Loire Valley. The next step was to choose some experts in the field who would contribute to the monograph and present their papers at a conference for the purpose of generating discussions. The action of the local committee, composed of Dr. A. Tixier-Vidal, Dr. Claude Kordon, and me, was crucial in this respect. The local committee proposed the program for the meeting and a list of the majority of contributors to be invited. I wish to thank Dr. Tixier-Vidal and Dr. Kordon for their invaluable assistance.

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Content:
Front Matter....Pages i-xxix
Structural Basis of Adenohypophyseal Secretory Processes....Pages 1-13
Immunocytochemical Identification of LH- and FSH-Secreting Cells at the Light- and Electron-Microscope Levels....Pages 15-37
Pituitary Polypeptide-Secreting Cells: Immunocytochemical Identification of ACTH, MSH, and Peptides Related to LPH....Pages 39-66
Exocytosis and Related Membrane Events....Pages 67-103
Intracellular Events in Prolactin Secretion....Pages 105-123
Separated Somatotrophs: Their Use in Vitro and in Vivo....Pages 125-166
Pituitary Secretory Activity and Endocrinophagy....Pages 167-186
Ultrastructural Localization of LH and FSH in the Porcine Pituitary....Pages 187-195
Localization of Anti-ACTH, Anti-MSH, and Anti-α-Endorphin Reactive Sites in the Fish Pituitary....Pages 197-208
Changes in the Responsiveness to LH-RH in FSH-Treated 4-Day Cycling Female Rats....Pages 209-215
Role of Gonadotropin-Releasing Hormone in the Biosynthesis of LH and FSH by Rat Anterior Pituitary Cells in Culture....Pages 217-235
Processing of the Common Precursor to ACTH and Endorphin in Mouse Pituitary Tumor Cells and Monolayer Cultures from Mouse Anterior Pituitary....Pages 237-261
Biosynthesis of β-Endorphin in the Rat Pars Intermedia....Pages 263-283
Effect of TRH on the Synthesis and Stability of Cytoplasmic RNAs of GH3B6 Cells....Pages 285-294
Hormonal Regulation of Prolactin mRNA....Pages 295-309
Pregrowth Hormone Messenger RNA: Glucocorticoid Induction and Purification from Rat Pituitary Cells....Pages 311-333
Adenohypophyseal Cell Specificities and Gonadal Steroids....Pages 335-362
Development of a Photoaffinity Probe for Adrenocorticotropin Receptors....Pages 363-380
Enzymatic Degradation of Hypothalamic Hormones at the Pituitary-Cell Level: Possible Involvement in Regulation Mechanisms....Pages 381-399
Methods of Labeling Pituitary Hormones....Pages 401-414
Mechanism of Action of Hypothalamic Hormones and Interactions with Sex Steroids in the Anterior Pituitary Gland....Pages 415-439
Binding of GnRH to the Pituitary Plasma Membranes, Cyclic AMP, and LH Release....Pages 441-462
Characterization of Thyroliberin (TRH) Binding Sites and Coupling with Prolactin and Growth Hormone Secretion in Rat Pituitary Cell Lines....Pages 463-493
Mechanisms Governing the Release of Growth Hormone from Acutely Dispersed Purified Somatotrophs....Pages 495-523
Pharmacological Studies of Pituitary Receptors Involved in the Control of Prolactin Secretion....Pages 525-542
The Release of ACTH by Human Pituitary and Tumor Cells in a Superfusion System....Pages 543-559
Interaction of Glucocorticoids, CRF, and Vasopressin in the Regulation of ACTH Secretion....Pages 561-585
Corticotropin Secretion....Pages 587-615
Modulation of Pituitary Responsiveness to Gonadotropin-Releasing Hormone....Pages 617-638
The Pattern of LH Release of Rat Pituitary Glands during Long-Term Exposure to LH-RH in Vitro....Pages 639-657
Functional Heterogeneity of Separated Dispersed Gonadotropic Cells....Pages 659-676
In Vitro Studies on the Secretion of Human Prolactin and Growth Hormone....Pages 677-721
Use of Cell Separation to Analyze the Mechanisms of Action of GnRH....Pages 723-729
TRH as MSH-Releasing Factor in the Frog....Pages 731-751
Effects of TRH and Bromocriptine in Acromegaly: In Vivo and in Vitro Studies....Pages 753-763
Intracellular Recordings from Prolactin-Secreting Pituitary Cells in Culture: Evidence for a Direct Action of Estrogen on the Cell Membrane....Pages 765-773
Extracellular Potassium Change in the Rat Adenohypophysis: An Indicator of Neurohypophyseal-Adenohypophyseal Communication....Pages 775-781
Back Matter....Pages 783-792

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Content:
Front Matter....Pages i-xxix
Structural Basis of Adenohypophyseal Secretory Processes....Pages 1-13
Immunocytochemical Identification of LH- and FSH-Secreting Cells at the Light- and Electron-Microscope Levels....Pages 15-37
Pituitary Polypeptide-Secreting Cells: Immunocytochemical Identification of ACTH, MSH, and Peptides Related to LPH....Pages 39-66
Exocytosis and Related Membrane Events....Pages 67-103
Intracellular Events in Prolactin Secretion....Pages 105-123
Separated Somatotrophs: Their Use in Vitro and in Vivo....Pages 125-166
Pituitary Secretory Activity and Endocrinophagy....Pages 167-186
Ultrastructural Localization of LH and FSH in the Porcine Pituitary....Pages 187-195
Localization of Anti-ACTH, Anti-MSH, and Anti-α-Endorphin Reactive Sites in the Fish Pituitary....Pages 197-208
Changes in the Responsiveness to LH-RH in FSH-Treated 4-Day Cycling Female Rats....Pages 209-215
Role of Gonadotropin-Releasing Hormone in the Biosynthesis of LH and FSH by Rat Anterior Pituitary Cells in Culture....Pages 217-235
Processing of the Common Precursor to ACTH and Endorphin in Mouse Pituitary Tumor Cells and Monolayer Cultures from Mouse Anterior Pituitary....Pages 237-261
Biosynthesis of β-Endorphin in the Rat Pars Intermedia....Pages 263-283
Effect of TRH on the Synthesis and Stability of Cytoplasmic RNAs of GH3B6 Cells....Pages 285-294
Hormonal Regulation of Prolactin mRNA....Pages 295-309
Pregrowth Hormone Messenger RNA: Glucocorticoid Induction and Purification from Rat Pituitary Cells....Pages 311-333
Adenohypophyseal Cell Specificities and Gonadal Steroids....Pages 335-362
Development of a Photoaffinity Probe for Adrenocorticotropin Receptors....Pages 363-380
Enzymatic Degradation of Hypothalamic Hormones at the Pituitary-Cell Level: Possible Involvement in Regulation Mechanisms....Pages 381-399
Methods of Labeling Pituitary Hormones....Pages 401-414
Mechanism of Action of Hypothalamic Hormones and Interactions with Sex Steroids in the Anterior Pituitary Gland....Pages 415-439
Binding of GnRH to the Pituitary Plasma Membranes, Cyclic AMP, and LH Release....Pages 441-462
Characterization of Thyroliberin (TRH) Binding Sites and Coupling with Prolactin and Growth Hormone Secretion in Rat Pituitary Cell Lines....Pages 463-493
Mechanisms Governing the Release of Growth Hormone from Acutely Dispersed Purified Somatotrophs....Pages 495-523
Pharmacological Studies of Pituitary Receptors Involved in the Control of Prolactin Secretion....Pages 525-542
The Release of ACTH by Human Pituitary and Tumor Cells in a Superfusion System....Pages 543-559
Interaction of Glucocorticoids, CRF, and Vasopressin in the Regulation of ACTH Secretion....Pages 561-585
Corticotropin Secretion....Pages 587-615
Modulation of Pituitary Responsiveness to Gonadotropin-Releasing Hormone....Pages 617-638
The Pattern of LH Release of Rat Pituitary Glands during Long-Term Exposure to LH-RH in Vitro....Pages 639-657
Functional Heterogeneity of Separated Dispersed Gonadotropic Cells....Pages 659-676
In Vitro Studies on the Secretion of Human Prolactin and Growth Hormone....Pages 677-721
Use of Cell Separation to Analyze the Mechanisms of Action of GnRH....Pages 723-729
TRH as MSH-Releasing Factor in the Frog....Pages 731-751
Effects of TRH and Bromocriptine in Acromegaly: In Vivo and in Vitro Studies....Pages 753-763
Intracellular Recordings from Prolactin-Secreting Pituitary Cells in Culture: Evidence for a Direct Action of Estrogen on the Cell Membrane....Pages 765-773
Extracellular Potassium Change in the Rat Adenohypophysis: An Indicator of Neurohypophyseal-Adenohypophyseal Communication....Pages 775-781
Back Matter....Pages 783-792
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